Scribd Logo
Upload

Welcome to Scribd!

  • 17 views

    Materi Ipm Blok 11

    Uploaded by

    nadya salsabila
    This document summarizes information about oral manifestations of hematological disorders like leukemia, thrombocytopenia, and hemophilia. Key points include common oral signs of these conditions such as bleeding, swelling, and infections. It also discusses evaluation and management of patients, noting risks of invasive dental procedures based on blood counts and coagulation status. Differential diagnoses and characteristics of various leukemia subtypes, platelet and red blood cell abnormalities are outlined.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content

    You might also like

    Materi Ipm Blok 11

    Uploaded by

    nadya salsabila
    17 views2 pages
    This document summarizes information about oral manifestations of hematological disorders like leukemia, thrombocytopenia, and hemophilia. Key points include common oral signs of these conditions such as bleeding, swelling, and infections. It also discusses evaluation and management of patients, noting risks of invasive dental procedures based on blood counts and coagulation status. Differential diagnoses and characteristics of various leukemia subtypes, platelet and red blood cell abnormalities are outlined.

    Original Description:

    Original Title

    MATERI IPM BLOK 11

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This document summarizes information about oral manifestations of hematological disorders like leukemia, thrombocytopenia, and hemophilia. Key points include common oral signs of these conditions such as bleeding, swelling, and infections. It also discusses evaluation and management of patients, noting risks of invasive dental procedures based on blood counts and coagulation status. Differential diagnoses and characteristics of various leukemia subtypes, platelet and red blood cell abnormalities are outlined.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    17 views2 pages

    Materi Ipm Blok 11

    Uploaded by

    nadya salsabila
    This document summarizes information about oral manifestations of hematological disorders like leukemia, thrombocytopenia, and hemophilia. Key points include common oral signs of these conditions such as bleeding, swelling, and infections. It also discusses evaluation and management of patients, noting risks of invasive dental procedures based on blood counts and coagulation status. Differential diagnoses and characteristics of various leukemia subtypes, platelet and red blood cell abnormalities are outlined.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    of 2

    Leukemia  leukopenia, anemia and

    thrombocytopenia
    Leukemia : penyakit keganasan pd jar
     leukemia infiltration of the gum
    hematopoeitik (proliferasi WBC)
    Differential Diagnosis
     AML acute myeloid leukemia
     ALL acute lymphoblastic leukemia  necrotizing acute gingivitis
     CML chronic myeloid leukemia  opportununistic infection caused by aids
     CLL chronic lympholytic leukemia  extramedullary leukemic infiltrate
    Etiologic Acute Lymphocythic Leukemia
    1. host factors :  usia 2-5 tahun
     hereditary  komplikasi oral : akibat leukeia / efek
     congenital chromosal abnormalities samping dr kemoterapi (sitostatika)
     immunodeficiency  treatment : metrotrexate
     chronic marrow dysfunction
    2. environmental Manifestasi Oral Khas Pada AML
     ionizing radiation  spontaneous gingival bleeding or oozing
     chemical drugs (tr<20.000)
     viruses  petechiae formation
    insidensi all banyak pada anak, aml banyak  oral soft tissue or gingival infection
    pada dewasa  pharyngitis
     lymphadenopathy
    perbandingan acute dan chronic
    Pemeriksaan Lab Leukemia
    acute chronic
    age all adults  cbc / peripheral blood smear
    clinical onset sudden insidious  cytochemistry
    course <6mo 2-6 yr  immunologic maker studies
    leukemia cell immature mature  cytogenetics
    anemia mild to sever mild  molecular genetics
    white blood variable increased
    Pertimbangan Dental

    Manifestasi Oral Leukemia  px dgn gejala fatique, infeksi, inflamasi,


    bleeding  CBC  diagnose the
     gingival swelling dan hemorraghe underlying cause
     mucosal purpura  WBCs >> : fulminant orofacial infections
     mucosal pallor  antibiotic dan rawat inap
     fungal and viral infections  beberapa obat  WBC <<
     oral ulcerations  defisiesi vitamil dan mineral  anemial
     lymphadenopathy dan oral symptoms
     cytotoxic therapy can provoke oral  RBC <<  evaluasi ukuran dan bentuk
    ulceration and mucositis RBCs (blood smear)
    oral and perioral effect of acute o Kemungkinan produksi RBCS
    leukemia <<
     mucosal ulcerations o Kehilangan darah >>
     herpetic infection and candidiasis o Destruksi RBC >>
     purpura  pada kondisi macrocytic anemia :
     anaemic ukuran RBC lebih besar daripada N 
     cervical lymphadenopathy kemungkinan defisiensi nutrisi (vitamin
     gingival swelling B12 dan folat)
     agen antineoplastic : produksi WBC <<  Perdarahan spontan : Tr =
     resiko tinggi postoperative infection <20.000/mm3
     tunda dental treatment sampai WBC
    normal Gangguan Autoimun

    Polycitemia Vera  Lupus/ Idiopathic thrombocytopenia


    purpura (ITP) antibodies menyerang
     peningkatan abnoral RBC platelets
     manifestasi oral tdk spesifik  resiko  Obat obatan : acetaminophen,
    tinggi terjadi trombotic events (dlm heparin, quinidine, sulfa digoxin
    terapi anticoagulant/antiplatelet) vancomycin, valium & nitroglycerine
     gangguan kualitas platelet  resiko  thrombocytopenia
    perdarahan  Radioterapi/ kemoterapi  platelet <<
     orthopnea di dental chair, dizziness,
    sakit kepala, wajah kemerahan dan Thrombocytosis
    dyspnea
     Jumlah platelet >>
     jarang berkembbang menjadi o Tanpa gejala
    hematologic malignancy (leukemia)
    o Gangguan myeloproliferative pada
    bone marrow
     Resiko :
    Thrombocytopenia & Thrombocytosis o Pada disfungsi platelet : tend to
    Pendahuluan perdarahan +
    o Fungsi normal  tend to
     Wanita hamil 6-10% thrombocytopenia overaggregate 
     Akibat destruksi platelet : pd penyakit thromboembolism / infark
    ginjal (selama hodialisis)
     Thrombotic thrombocytopenia purpura Vonn Wilebrand’s Disease
    (TTP) dan hemolytic uremic syndrome  Underdiagnosed : ditemuka jika px akan
    (HUS) : pada gagal ginjal  sikrulasi
    bedah minor/ekstraksi
    platelet <<  platelet
     1% pd populasi
     Thrombocytopenia : observasi pd px
     Menyebabkan bruising / bleeding (krn
    dgn long-termn bleeding problem (peptic
    disfungsi platelet)
    ulcer berdarah, HIV/AIDS, sepsis gram
     Jm platelet norma, kemmapuan
    (-))
    agregasi dan berikatan < karena
     Thrombocytopenia (jm platelet >>) : life
    kekurangan fungsi von willebrand
    threatening risk  evaluasi medis
    (protein untuk memulai pembekuan)
    segera dan transfuse paletlet
     Tunda invasive dental care jika jumlah Manifestasi Oral Hemofilia
    platelet <50.000/mm3
     Thrombocytopenia pd hematologic Early stage
    malignancy (leukemia) krn jm sel  Hyperplastic gingivitis
    ganas>>, normal bone marrow cells  Spontaneous gingival hemmorrhage
    terganggu  produksi platelet <<
     Persistent acute ulcerative gingivitis
    Lab D/ Platelet Count  Oral ulceration

     Untuk mengetahui angguan perdarahan Late stage


    dan leukemia  invasive surgery
     Severe hemorrhage
    didahului pem. darah
     Hyperthropic gingivitis
     Resiko perdarahan jika : Tr = 50.000
    platelet / mm3

    You might also like