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  • Single Emulsion Techniques: Aq - Solution/suspension of Polymer Stirring, Sonication

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    Single emulsion techniques involve dispersing an aqueous polymer solution or suspension into an organic phase using stirring or sonication to form microspheres, which are then cross-linked and separated. Double emulsion techniques disperse an aqueous polymer solution containing a drug into an organic phase, then emulsify it further in an aqueous PVA solution to form microspheres, which are then separated. Coacervation techniques involve inducing phase separation in a homogeneous polymer solution containing a drug to form polymer-rich globules, which are then hardened and separated into microspheres.

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    Single emulsion techniques involve dispersing an aqueous polymer solution or suspension into an organic phase using stirring or sonication to form microspheres, which are then cross-linked and separated. Double emulsion techniques disperse an aqueous polymer solution containing a drug into an organic phase, then emulsify it further in an aqueous PVA solution to form microspheres, which are then separated. Coacervation techniques involve inducing phase separation in a homogeneous polymer solution containing a drug to form polymer-rich globules, which are then hardened and separated into microspheres.

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    30 views5 pages

    Single Emulsion Techniques: Aq - Solution/suspension of Polymer Stirring, Sonication

    Uploaded by

    Hide Anomous
    Single emulsion techniques involve dispersing an aqueous polymer solution or suspension into an organic phase using stirring or sonication to form microspheres, which are then cross-linked and separated. Double emulsion techniques disperse an aqueous polymer solution containing a drug into an organic phase, then emulsify it further in an aqueous PVA solution to form microspheres, which are then separated. Coacervation techniques involve inducing phase separation in a homogeneous polymer solution containing a drug to form polymer-rich globules, which are then hardened and separated into microspheres.

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    Single emulsion techniques

    Aq.solution/suspension of polymer

    Stirring, sonication

    Dispersion in organic phase oil/chloroform

    Cross linking
    Heat denaturation Chemical
    cross -linking

    Microspheres in organic phase Microspheres in organic phase

    Centrifugation, Washing, Separation

    Microspheres
    11
    Double emulsion techniques
    Aq.sol of polymer + drug

    Dispersion in organic phase


    Homogenization or sonication

    First emulsion

    Addition to aq. Sol. Of PVA

    Multiple emulsion

    Addition to large aq. phase

    Microsphere in solution

    Separation, washing, drying


    Microspheres
    7
    COACERVATION / PHASE SEPARATION:
    PHASE

    SEPARATION

    Homogeneous Coacervate
    Droplets
    Polymer Solution Droplets

    MEMBRANE

    FORMATION

    Polymeric
    Membrane

    Process consist of 3 phases:


    1.Formation of three immiscible phase
    2.Deposition of coating
    3.Rigidization of coating.
    Phase Separation Coacervation Technique

    Aq/ organic solution polymer

    Drug

    Drug dispersed or dissolved in the polymer solution

    Phase separation induced by different means

    Polymer rich globules

    Hardening

    Microspheres in aq/ organic phase

    Separation, Drying
    MICROSPHERES
    14
    Step: 1) Three immiscible phases are as:
    a) LMVP
    b) Core material phase
    c) Coating material phase.

    Coating material phase formed by utilizing following methods:


    A) Temperature change.
    B) By addition of incompatible polymer
    C) By non-solvent addition
    D) By salt addition
    E) Polymer-polymer interaction.

    15

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