TUGAS ESSAY KOMSTAT

Nama : Farhan Haidar Fazlur Rahman

Prodi : Urologi
NPM : 22061443665

1) Suatu penelitian kerangka mengkaji efektifitas pembedahan preventif (surgery) di suatu perusahaan untuk
mencegah relaps stroke pada bulan antara pertama dan ketiga (stroke2/Stroke between 1 and 3 months):

a) Tabel karakteristik subyek

Table 1. Patient characteristics

Surgery
Variable
Cerebral Carotid None
angioplasty endarterectomy
Diabetes, n (%)

Yes 8 (15.1%) 20 (37.7%) 25 (47.2%)

No 70 (10.0%) 303 (43.3%) 326 (46.6%)
Age Category, n (%)

45-54 18 (10.1%) 81 (45.3%) 80 (44.7%)

55-64 34 (11.8%) 118 (40.8%) 137 (47.4%)
65-74 19 (9.0%) 83 (39.3%) 109 (51.7%)
75+ 7 (9.6%) 41 (56.2%) 25 (34.2%)
Stroke between 1 and 3 months, n (%)

Yes 2 (5.4%) 3 (8.1%) 32 (86.5%)

No 76 (10.6%) 320 (44.8%) 319 (44.6%)
Time to hospital

Median (min – max) 2.5 (1 – 6) 3.0 (1 – 6) 3.0 (1 – 6)

 b) Hasil uji perbandingan proporsi bivariat antara faktor risiko yang sesuai dengan stroke2

Table 2. Statistical analysis of factors influencing stroke between 1 to 3 months

Stroke between 1 to 3 months

Variables Total P value OR (CI 95%)
Yes No
Surgery

Carotid endarterectomy 3 (0,9%) 320 (99.1%) 323 < 0.001CS 0.09 (0.03 – 0.31)
Cerebral angioplasty 2 (2.6%) 76 (97.4%) 78 0.26 (0.62 – 1.12)
None 32 (9,1%) 319 (90.9%) 351 Reference
Diabetes

Yes 13 (24.5%) 40 (75.5%) 53 < 0.001F 9.14 (4.33 – 19.28)

No 24 (3.4%) 675 (96.6%) 752 Reference
Age Category

45-54 7 (3.9%) 172 (96.1%) 179 0.006CS 0.29 (0.10 – 0.81)

55-64 8 (2.8%) 281 (97.2%) 289 0.20 (0.08 – 0.54)

65-74 13 (6.2%) 198 (93.8%) 211 0.47 (0.19 – 1.14)

>75 9 (12.3%) 64 (87.7%) 73 Reference

CS = Chi-square, F = Fisher exact test

c) Hasil uji perbandingan rerata antara faktor risiko yang sesuai dengan stroke2 dilengkapi dengan diagram
boxplot perbandingannya

Table 3. Statistical analysis of time and hospital to stroke

Stroke between 1 to 3 months

p-value
Yes (n=37) No (n=715)
Time to hospital 3.0 (1 – 6) 2.8 (1 – 6) 0.411MW
MW = Mann-Whitney test

Figure 1. Boxplots of time to hospital and stroke between 1 and 3 months

 d) Hasil uji multivariat seluruh faktor risiko dengan stroke2

Stroke between 1 to 3 months

Variables Total P value OR (95% CI) P value aOR (95% CI)
Yes No
Surgery

Carotid endarterectomy 3 (0,9%) 320 (99.1%) 323 < 0.001CS 0.09 (0.03 – 0.31) <0.001 0.07 (0.02 – 0.25)
Cerebral angioplasty 2 (2.6%) 76 (97.4%) 78 0.26 (0.62 – 1.12) 0.22 (0.05 – 1.00)

None 32 (9,1%) 319 (90.9%) 351 Reference Reference

Diabetes

Yes 13 (24.5%) 40 (75.5%) 53 < 0.001F 9.14 (4.33 – 19.28) <0.001 11.8 (5.03 – 27.7)
No 24 (3.4%) 675 (96.6%) 752 Reference Reference

Age Category

45-54 7 (3.9%) 172 (96.1%) 179 0.006CS 0.29 (0.10 – 0.81) 0.002 0.21 (0.07 – 0.67)
55-64 8 (2.8%) 281 (97.2%) 289 0.20 (0.08 – 0.54) 0.12 (0.04 – 0.36)

65-74 13 (6.2%) 198 (93.8%) 211 0.47 (0.19 – 1.14) 0.28 (0.10 – 0.79)

>75 9 (12.3%) 64 (87.7%) 73 Reference Reference

Adjusted R2 = 27.5%
2) Suatu penelitian kerangka mengkaji faktor apa saja yang berhubungan dengan kecepatan waktu untuk merujuk
pasien ke rumak sakit pada pasien stroke (time):

a) Tabel karakteristik subyek

Tabel 1. Tabel karakteristik pasien

Mean / Median / Frekuensi

Time 3.0 (1 – 6)
Age 62.5 (9.1)
Hospital size

Small 358 (34.2%)

Medium 93 (8.9%)
Large 597 (57.0%)

b) Hasil uji perbandingan korelasi hubungan usia dengan time, tampilkan scatter plot

Gambar 1. Scatter plot antara usia dengan waktu yang dibutuhkan untuk merujuk

Hasil uji korelasi spearman antara usia dalam tahun dengan waktu yang dibutuhkan dalam hari pada kelompok kasus
berdasarkan uji korelasi spearman menunjukkan adanya hubungan secara statistik, namun tidak meunjukkan adanya
korelasi (p = 0.027, r = 0.068)
c) Hasil uji perbandingan hospital size dengan time

Tabel 2. Uji perbandingan hospital size dengan time

Variable n Time to hospital Overall p-value Inter-group p-value

Hospital Size

Small 358 3.0 (1 – 6) 0.504KW Reference

Medium 93 3.1 (1 – 6) 0.448MW

Large 597 2.9 (1 – 6) 0.557MW

KW = Kruskal-Wallis, MW = Mann-Whitney

d) Hasil multivariat kedua variabel dengan time

Tabel 3. Regresi linear hospital size dan age terhadap waktu rujuk

Parameter Standard error 95% CI p-value

Parameter
estimate

Intercept 2.355 0.297 1.772 – 2.938 < 0.001

Hospital size - 0.038 0.044 - 0.126 – 0.049 0.388
Age 0.011 0.005 0.002 – 0.02 0.013

The multiple linear regression equation is given by:

Time = 2.355 + 0.011 (age), depending on age in years of these patients.

Adjusted R square = 0.5%