Pexkirwan : 400.000 arok dan remasp, usa O-$4 thn roar ont tg hu Sites (Sivtan Raystrosi Kanken di [noneni)) 2005 -200% + (0-17 4m) ~ 4 /roox, anak. (0-5the) ~ 8 foo, aco (5-Hitha) ~ loo anole. Ledertio. pd ook ( 2,8 per 100%) Boia tuner -astryt60. pa byt deft ey 9 Gens mney funs (a0 enpal Ofer the co-tuin davlogs louima’) - Highercise bas Cerenet cette! Arg), © Benzene — AML fan) 21 (latres bigs) wwe 3? UL > nitro mustard ~ AL. > ‘eal ALL *) cufotorie ~ alata’ renal “A ng Haga LEUKEMIA 1 rere ere O AU-"BorT lymphoblastic leakenia” 76%. @ AML- 20% Oboste cndief eskemia, 0.5% One mixel-Lnean laos. conc ML - 3% - Philadaphio - poative ive muydloid unt phe fae ms © Jwerile Mgolarenoeytic Leake “Tpereaghan diogneis top Cone Morro Fartine. Incidence 20-20% konken ovale = laukimca.. Peeks af 2-6 yews {"\enizicg Rode A ‘4 ace fare AML, rehire yen Yon Foncane ‘anania (eukia® 1:60. * Bloom syndrom seas often f- 2 genre, peaks FYB yeane Yn radius Jhon of epicenter 4) Ururod fisiens Gh by 3) Ingection_ 9 Wynphare - What pide, My, 7 Hanon Tellestera virus. (HTLV) ~Tehtynphon, amma eee, 2 Epstein Boer — Burkitt lymphsoa 5%; sosia ecengnsmic % HIV: Moeiderce of ' Acute b ie Aeuleemio, (ALL) Se Ss setnmons{ 136% ofc “/ anc on: Sede teres: an 2 a2 afm Hy tote. ot 2-Sy. a 0g ~+ peterhine/p , ine 20y nnihe ea Gone Fade ae is 5 38, rillagn oe aeped if ~» Obat-antinyer; go Somboh © Lyapheblost LL >> V.CSip. Syrcrore = Anemia. lob hi, Neral /oraria.. nermocyticnsrmoch Sees aoypertie ten. ges ae are Chetan ae osteo etauses Gi taney ty ot (etm Lyaphsid BM: >5% blest. “Flee Treatment : Frevent TLS ~Heparomgaly, + Neutropenia + Febrile Reudemeras, frehoseco ped © Dipindai dengan CamScannerFrognerrs Ala (fayerble vs. Unfeverable) —Tergantung, WRC csunt soatpetome, Aogrssa (>50rb =fele = loki" > pexorpuen ~ Age 2-T beltertha <2 60240. Hig: EBV, outoraun| : i t yekies -S4] ie . Tregiment : Tosspontasi BM, Froayget fake Sor hes — DH - std Gas end of ae ie ynphonn. = = Specht a . 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(wet), | Chilgren hipebe thy Ae Lrowacpbsnahn perp / oe ~ etrodina : mecentira) | sli ane | Drage: cr, mn, FET pS Eee cee ser — Maltidiscipline coordination. oe Pee ce infmewslan, (5.040 eye refles Malignant, congenital tuman of ett. CH: - Lekocerio aint Sa dspot Engh fone acquired - Strabismus Terepi: Chemstheraphy enucleation ~OniSousnid Guavival, 89 -9pe, —regona here tee faa rabath oe : Serving 2° malpronay (3 peg MRE; er mtn nochmal ves am © Dipindai dengan CamScannerae egies bli Kionker—s gmelle olla mun; en (ose rh cS Poe fn aaa (1st _shY/ath mudstiony Ge ep purrs menflay’ ip. By pass Apoposs“ (ps3 J f | Cllrs ey re! s (p53) Bae Moloutes Intenpieg +7 etna baa VON Prete eran pul enleyen > gi ipo aa ea Kimortaligess f CDC (ca Gi-S-G ns 4 DNA cepaic Crelomen) dipongen, & fe eS pendent Kite “ABODE Imortalicsss (mesronyorajon telarien) coeds = Fisk-on —rbeo sd toner (99%, tame; fleeneresen yo oeif) @oarsigaiog a (0) Greuth paters ~ miter” OSteate Roe —>ackivte MiP kinase — Inte (transkapsi Nye gend) Cetuxiena Atnigted theroghy konke Koln, chp seat K-RAS wild type /-e muta fetind SS tee, RAE MAP Kare. ae oral gp eruiacs ~7kalou utes 9 op bernard | (© Kelaln Qreayres 2 ee (eles Sc [oem > Print mutation % gre amplification. ~ Qrorpreductian of gioutnfocters. (everpredulsi) ar Ccppaseie Floedicg the cdl / repecakin sols. (any sig) Spee tania ~ imal yy te toaninel et ~ Pertaribuhen sel oteh Torccnipion fton yg mentroeat Tete Sak cme heint oe gies genes fe m | omega ar 9 a Sorts Bot ARL — Trotleation a pee » FS pega Fader tal (© lates: Btercon en carrie eee gen-line. chamical, fodtatien, virus AA ara fos ecire Fars)— ee pation = bet ee nenpal ln ra (Thyme E Reg - “UW Sh gee (aed ata) st © Dipindai dengan CamScannerEE SSS ULULUlU—™ 2) DNA repase : - mismateh enalows Pigment: Kon Honalenaue Gd Tain = pig guaah, hose &. Gypteotide exciviay repad ay af Ie > led One ~ repair OF double sted broks. rg gl Sap stays ders tat mgeoten, | [ote BS ~invobien of teu Figo) poten) ~ metastasis. OWA intonks; dg ° |— ‘ipemetilas_ adhe Mewcratous poly pois cls (APC) eonly activation (eet edntion, hah dayee of gute hnonmolte: pee = aneuploidy, om! | loss, & Bee eee nai cae ie % nt eke — to avon (pre pop texts Y Benes, Inxtabilaty Cer’) bey 9% Mieratilite lnfability — Ca" bonulay es mt apryn> — Spt Metta’ > Ytzang 8 crorén — ype : ree eee antes Is ental elope Sustoan Susitivty 94,300 ™, L sea 819%, > 24 gem :- Oty y “S92 Iga sams = Mye “Ket © Dipindai dengan CamScanner