Scribd Logo
Upload

Welcome to Scribd!

  • 22-23 - Oncology - Test Exam Ch1-6

    Uploaded by

    Levi Grift
    6 views2 pages
    Benign tumors usually grow slower and are less invasive and metastatic than malignant tumors. An effective anticancer medicine inhibits tumor growth in many patients. UV radiation induces pyrimidine dimers in DNA. Nucleotide excision repair involves the induction of pyrimidine dimers. Transcription factors contain a DNA-binding domain but not necessarily other domains. Epigenetic modifications are heritable. RAS is a kinase that binds ATP to activate itself. Protein kinases, phosphatases, and GAPs regulate protein activity through phosphorylation. Pocket protein pRB binds transcription regulators E2F and cyclin D. Methylation of p16 inactivates the p16 gene and disrupts the G1 checkpoint, inducing

    Original Description:

    Original Title

    22-23 - Oncology - test exam Ch1-6

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Benign tumors usually grow slower and are less invasive and metastatic than malignant tumors. An effective anticancer medicine inhibits tumor growth in many patients. UV radiation induces pyrimidine dimers in DNA. Nucleotide excision repair involves the induction of pyrimidine dimers. Transcription factors contain a DNA-binding domain but not necessarily other domains. Epigenetic modifications are heritable. RAS is a kinase that binds ATP to activate itself. Protein kinases, phosphatases, and GAPs regulate protein activity through phosphorylation. Pocket protein pRB binds transcription regulators E2F and cyclin D. Methylation of p16 inactivates the p16 gene and disrupts the G1 checkpoint, inducing

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    6 views2 pages

    22-23 - Oncology - Test Exam Ch1-6

    Uploaded by

    Levi Grift
    Benign tumors usually grow slower and are less invasive and metastatic than malignant tumors. An effective anticancer medicine inhibits tumor growth in many patients. UV radiation induces pyrimidine dimers in DNA. Nucleotide excision repair involves the induction of pyrimidine dimers. Transcription factors contain a DNA-binding domain but not necessarily other domains. Epigenetic modifications are heritable. RAS is a kinase that binds ATP to activate itself. Protein kinases, phosphatases, and GAPs regulate protein activity through phosphorylation. Pocket protein pRB binds transcription regulators E2F and cyclin D. Methylation of p16 inactivates the p16 gene and disrupts the G1 checkpoint, inducing

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    of 2

    EXAM 1: TEST EXAM

    Ch1
    Benign tumors usually grow slower/faster, are more/less invasive and give no/less/more
    metastases than malignant tumors.
    Ch1
    True or False: An anticancer medicine has a good therapeutic index if it is very effective in
    inhibiting tumor growth in many patients.
    Ch2
    The induction of pyrimidine dimers in DNA is typical after:
    a. X-rays
    b. Oxidative damage
    c. UV radiation
    d. Polycyclic aromatic hydrocarbons (PAH)
    Ch2
    The situation below is a step in the following DNA repair mechanism:
    a. Base excision repair.
    b. Nucleotide excision repair.
    c. Mismatch DNA repair.
    d. Cross-link repair by the FA network

    Ch3
    Transcription factors are proteins consisting of multiple domains each with a specific
    function. Which of the following is TRUE:
    a. All transcription factors contain a DNA-binding domain
    b. All transcription factors contain a ligand-binding domain
    c. All transcription factors contain a dimerization domain
    d. None of the above
    Ch3
    True or False: epigenetic modifications are heritable.
    Ch4
    RAS binds ATP which activates it
    RAS proteins are kinases
    a. 1 is correct, 2 is incorrect
    b. 1 is incorrect, 2 is correct
    c. 1 and 2 are correct
    d. 1 and 2 are incorrect
    Ch4
    Phosphorylation is an important functional modification of proteins. Which enzymes are
    important in the regulation of protein activity by phosphorylation?
    a. Protein kinases
    b. GTP-ase activating proteins (GAPs)
    c. Protein phosphatases
    d. A, B en C

    Ch5
    pRB is a so-called pocket protein that binds two important transcription regulators. Which
    are these two proteins?
    a. Cyclin D and E2F
    b. Cyclin E and HDAC
    c. CDK4 and HDAC
    d. E2F and HDAC
    Ch5
    Methylation of p16 is often found in different types of tumors, such as in colorectal
    cancer. What are the consequences of p16 methylation?
    a. Activation of telomerase
    b. Loss of G1 checkpoint and induction of S-phase
    c. Inactivation of p53
    d. Induction of cyclin B
    Ch6
    Are the following statements correct?
    a. If one of the p53 alleles in a cell mutates this causes cancer
    b. If p53 function in a cell is completely lost, this causes cancer

    Ch6
    The activity of p53 is regulated primarily at the level of….
    a. Transcription
    b. Translation
    c. Degradation
    Ch6
    P53 mutations in cancer cells occur often in….
    a. the p53 promoter
    b. its DNA binding domain
    c. its Rb binding domain
    d. its MDM2 binding domain

    You might also like