Professional Documents
Culture Documents
Er Math
Er Math
ER MATH
OBJECTIVES
- To Discuss and Update different Formulas used in the Emergency Room
- To have uniformity on all orders written in the chart
1
3/16/2023
CASE:
BASIC CONCEPTS
CORRECTED SODIUM 23 yr old male with Type 1 DM came in with
drowsiness. He tested positive Ketone hence DKA
is considered. RBS 450mg/dl; Na: 152
CORRECTED SODIUM :
FORMULA = Actual Na + [0.016 x ( RBS-100)]
= Actual Na(mEq/L) + 0.016 x [RBS(mg/dl ) = 152mEqs/L + [0.016 x ( 450mg/dl - 100
- 100)]
)]
= 157.6mEqs/L (True Sodium)
Serum Sodium falls in proportion to ECF
dilution, declining 1.6mEq/L per 100mg/dll
increase in RBS
In marked hyperglycemia, ECF osmolality
increases
-IM Platinum, 2018, p94
BASIC CONCEPTS
ANION GAP
ANION GAP (AG):
= Na - (Cl + HCO3)
*Na; Cl; HCO3 : mmol/L or mEq/L
BASIC CONCEPTS
SODIUM DEFICIT Hyponatremia is almost always caused by impaired renal
water excretion; hence, assessment & correction of volume
status is important in correcting the deficit
Definition: Na < 135 mmol/L Identify by history and PE if the hyponatremia is
hypovolemic, euvolemic or hypervolemic. Correct
hemodynamic instability first before correcting hyponatremia
DETERMINE RATE OF CORRECTION:
ACUTE(<48hrs) & severely symptomatic (seizures) = 4-
6mmol/L within the first 2-4 hours, with frequent sodium
monitoring
CHRONIC/assymptomatic = not more than 8-10mmol/L in
any 24 hr period
-IM Platinum, 2018, p98
2
3/16/2023
BASIC CONCEPTS
SODIUM DEFICIT
CHANGE IN SERUM Na:
= (Infusate Na + Infusate K) -Actual Serum Na
TBW +1
AMOUNT OF FLUID
= Change in Serum Sodium desired
Estimated effect of 1L infusate
CHANGE in Serum Na
= (154 + 20) - 120]
36 +1
= 1.46mmol/L
*Rate desired in this case : 7mmol/L in 24 hrs
AMOUNT of FLUID = 7mmol / 1.46mmol/L = 4800ml
DETERMINE RATE OF CORRECTION: DRIP RATE: 4800ml/24h = 200ml/hr
ACUTE(<48hrs) & severely symptomatic (seizures) = 4-6mmol/L
within the first 2-4 hours, with frequent sodium monitoring
ORDER:
CHRONIC/assymptomatic = not more than 8-10mmol/L in any
24 hr period Start IVF with PNSS 1 L + 20mEqs KCl at 200ml/hr
-IM Platinum, 2018, p98
BASIC CONCEPTS
SODIUM DEFICIT
Definition: Na < 135 mmol/L
3
3/16/2023
CASE:
10
CASE:
Serum Na = 105 in a 50kg patient, what is the deficit and
BASIC CONCEPTS how will you correct using 3% Saline?
SODIUM DEFICIT
Sodium Deficit
Target Sodium: 125 -135 mEq/L (average : 130mEq/L)
Na deficit = 0.6 x wt(kg) x (Desired Na - Actual Na)
= 0.6 x 50kg x ( 130 - 105 )
= 750mEq/L needed to be replaced
= 750 mEq/L / 513 (using 3% saline)
= 1.462 % OR 146ml
= 146ml / 24 hours
= 6.08 or 6ml per hour
ORDER:
Hook to patient 3% Saline at the rate of 17 ml per hour
11
FORMULA
BASIC CONCEPTS
= [( 3.5 - actual K) X BW(kg) x 0.4
POTASSIUM DEFICIT *Target K for cardiac patients is usually 4; otherwise, a target of 3.5
is used
-Tintinalli, 9th Ed
Definition: K < 3.6 mmol/L
EQUIVALENT mEQs CASE: 60kg patient; Serum K = 2.5, what is the deficit and how will you
correct?
15cc 10% oral KCl sol’n : 20mEqs/L
30cc 10% oral KCl sol’n : 40mEqs/L
KCl tab 600mg: 8 mEqs K Potassium Deficit
KCl tab 750mg: 10mEqs K
= 24mEqs
1 average size banana : 11 - 12 meQs K
-IM Platinum, 2018 Oral K Correction is preferred therapy
We can address deficit using 10% oral KCl solution (30cc =
CORRECTION 40mEqs)
IV route - limited to those unable to utilize enteral route or those w/
severe complications (i.eparalysis, arrhythmia)
Give 30cc of 10% oral KCL for total of 9 doses every 6 hours
Use saline solo’s; dextrosed- induced increase in insulin can acutely
trigger hypokalemia
12
4
3/16/2023
BASE DEFICIT
Sodium Bicarbonate is usually given to patients with
acute and severe metabolic acidosis or pH < 7.1 to = (24 - 6 ) x 0.4 x 75
raise plasma HCO3 levels to approx 15mEqs/L
Usual initial target (desired HCO3 concentration is = 540mEq
10-12 meQs/L, which should bring blood pH to 7.20
To obtain deficit in grams, divide mEq by 12
IM Platinum, 2018
ORDER:
Loading 150mEq IV slow IV push the 350mEqs IV in
1L PNSS drip to run for 24 hours
May give half of dose as IV bolus over 3-4 hours;
remaining as drip after reassessment within 24
hours
IM Platinum, 2018
13
BASIC CONCEPTS
DOPAMINEDRIP
200mg in 250ml
14
15
5
3/16/2023
BASIC CONCEPTS
DOBUTAMINE DRIP
250mg in 250ml
Therapeutic (Tx) dose: 2-20mcg/kg/min
Cardiovascular Effects:
↑BP, CO Rate: (Tx dose / Stock dose) x weight
=/↑ HR
= MAP
↓SVR
Contraindications:
Hypertrophic cardiomyopathy w/ outflow tract
obstruction
Tintinalli, 9th ed, p134
16
17
BASIC CONCEPTS
NOREPHINEPHRINE DRIP
Contraindications:
Hypotension from hypovolemia except as an
emergency measure to maintain coronary and
cerebral perfusion until volume can be replaced
Tintinalli, 9th ed, p134
18
6
3/16/2023
19
20
BASIC CONCEPTS
NITROGLYCERIN DRIP PREPARATION: One 10ml ampule contains 10mg
Nitroglycerin
ORDER:
10mg NTG + 90ml D5W in a soluset
This will give a concentration of 0.1mg/ml (or 100mcg/ml)
USE: NTG
Organic nitrate w/c causes systemic DOSE:
ventilation, decreasing preload & after load
& reducing myocardial oxygen demand; Initial dose: 5mcg/min (for HTN urgency)
improves coronary collateral circulation
Titrate by 5mcg/min q 5mins until pain relief or BP is
controlled
-IM Platinum, 2018 p 87
21
7
3/16/2023
22
23
24
8
3/16/2023
BASIC CONCEPTS
ISOSORBIDE DINITRATE
DRIP ORDER:
10mg in 90ml Plain NSS to run 5ml/hr to abolish
chest pain. Titrate to increment and decrement of
ACTION: Relaxes vascular smooth muscle in 5 ml/hr. Hold for SBP less than 100mmHg
arteries, arterioles and veins through metabolic
conversion of organic nitrates to nitric oxide
USE: AMI patients not treated w/ thrombolytics,
reduces infarct size, improves regional function, &
decreases rate of cardiovascular complications
Contraindicated: Hypotension; use cautiously in
inferior wall ischemia
Tintinalli, 9th ed, p348
25
26
Example:
60kg Patient
Give Mannitol 20% 300ml intravenous bolus now then 150ml
intravenous every 4-8 hours
27
9
3/16/2023
Example:
60kg Patient
Desired Dose : 0.5g Mannitol / weight (kg) = 30g
Compute: 20g /100ml = 30g / X
X = ml / hr (Amount to administered)
X = (30 x 100) / 20
X = 150 ml
28
29
Desired FiO2
(Desired PaO2 x Actual FiO2)
PULMONOLOGY
Actual PaO2
DESIRED FIO2 Desired PaO2 : Obtained using formula
Desired PaO2 Actual PaO2 : Obtained from ABG
AGE < 60y/o Increasing FiO2 can increase PaO2 & SpO2 to desired levels
= 104 - (0.43 x age)
AGE > 60y/o and above Example Case:
= 80 - (Age - 60) ABG at Fio2 70% MV shows PaO2 of 78, 83year old patient
-IM Platinum, 2018, p59
Desired PaO2
% FiO2 = 80- ( 83 - 60 )
NC : (lpm x 4) + 20 = 57
Intubated : 100 %
MVM : 30- 50 % or 0.5 Desired FiO2
= (57 x 0.70) / 78
Room Air : 21% or 0.21
= 0.51 or 51%
Inline nebulization: >60%
-IM Platinum, 2018, p.59
30
10
3/16/2023
PULMONOLOGY
PF RATIO
PFR
PaO2 : arterial O2 partial pressure;
obtained from ABG = ( PaO2) / (FiO2)
FiO2 : Fraction of Inspired Oxygen at
time the ABG was withdrawn Severity of ARDS
MILD : 200 - 300 mmHg
MODERATE : 100 - 199 mmHg
SEVERE : < 100mmHg
-IM Platinum, 2018, p 60
31
PULMONOLOGY
BIPAP SETTINGS
EPAP (E): 5
IPAP (I): 10
Ratio E : I
1 : 2-2.5
32
PULMONOLOGY
EXERCISE COMPUTATION NOTES
”= 60 /0.8”
CASE: PFR Severe ARDs
40M (70kg) “= 75”
“= 104 - (0.43 x 40)”
FiO2 : 80% Desired PaO2 “= 104 -17.2”
ABG “= 86.8mmHg”
pH : 7.35 Desired FiO2
pCO2 : 38mmHg “= (0.8 x 87) / 60” approximates 100%
33
11
3/16/2023
34
ENDOCRINOLOGY
INSULIN DRIP
HYPERKALEMIA
Insulin causes K shift (Extracellular K goes
intracellularly)
Glucose- Insulin (GI) Solution: 50ml of 50% dextrose
in water (D50-50) + 10 units regular insulin in 2-5
mins
Sample Order : Mix 1 amp D50-50 with 10 units
Regular Insulin (GI Solution) IV stat, then every 6
hours x 4 doses
IM Platinum, 2018, p89
35
HYPERGLYCEMIA
FORMULATION of INSULIN DRIP (depends on physician)
EXAMPLES:
ENDOCRINOLOGY
DRIP 1: 20 units of HR in 100ml PNSS : conc of 0.2 unit/L
INSULIN DRIP DRIP 2: 50 units of HR in 100ml PNSS : conc of 0.5 unit/L
DRIP 3: 100 units of HR in 100ml PNSS : conc of 1 unit/ml
IM Platinum, 2018, p89
EXAMPLES:
EXAMPLE 1: if we decide to give 2 units of insulin per hr via insulin
drip
DRIP 1: give 10ml/hr
DRIP 2: give 4ml/hr
DRIP 3: give 2ml/hr
IM Platinum, 2018, p89
EXAMPLES:
EXAMPLE 2: Start Insulin drip at 0.1 unit/kg/hr & titrate to desired
blood glucose
If patient weighs 50kg, start insulin drip ar 5units/hr.
If we decide to use DRIP 3 from above example: Insuline drip 100
units HR + 100ml PNSS at rate of 5ml/hr (to deliver 5 units/hr)
IM Platinum, 2018, p89
36
12
3/16/2023
ENDOCRINOLOGY
DIABETIC DIET
FORMULA
= {[(Ht in cm) - 100] x 25}
(50-20-30) divided into 3 meals, 2 snacks and 1 fruit
exchange per day with no sources of simple sugar
and less than 7 % saturated fat.
37
NEPHROLOGY
CrCl(male):
CREATININE (140 - age x wt)
CLEARANCE (Plasma crea x 72)
38
39
13
3/16/2023
40
PEDIATRICS
1 x ETT (Age/4) + 4 (uncuffed tubes)
NEONATOLOGY 2 x ETT NG / OG / Foley Size
3 x ETT Depth of ETT insertion
Chest tube size (max, eg.
4 x ETT
Hemothorax)
5 year old
1 x ETT 5-0 ETT
2 x ETT 10f NG / OG / Foley Size
3 x ETT 15 cm ETT insertion depth
20Fr Chest tube size (max, eg.
4 x ETT
Hemothorax)
41
Weight
First 10 Kg 100ml/kg/day
PEDIATRICS
11 - 20kg 50ml/kg/day
HOLLIDAY SEGAR
Succeeding Kg
METHOD Above 20kg
20ml/kg/day
Weight
Shortcut: First 10 Kg 100 x 10 1000ml
11 - 20kg 50 x 10 500ml
If patient is above 20kg, automatic
Succeeding Kg
1500ml fluid requirement Above 20kg
5 x 20 100ml
TOTAL 1600ml
42
14
3/16/2023
43
TRAUMA - ADULT
PARKLAND FORMULA
= 4 x 70 x 50 = 1400ml
= 14000 / 2 = 7000ml
FLUID REQUIREMENT
= 7000 / 8 = 875ml /hr for first 8 hours
= 7000 / 16 = 438ml/hr for the next 16 hours
44
TRAUMA - ADULT
PARKLAND FORMULA
45
15
3/16/2023
First 24 hours (for 2nd & 3rd degree burns greater than or
equal to 15% TBSA burned)
TRAUMA - PEDIA 4ml LR x wt (kg) x % TBSA PLUS Maintenance Fluid
(D5LR)
PARKLAND FORMULA Give half over the first 8 hours (starting from time of
burn)
Next hand over the next 16 hours
46
COMPUTATION
4ml LR x 25kg x 30 = 3000ml
3000ml / 2 = 1500ml
= 1,500ml + 1,600ml (maintenance fluid by wt)
3,100 / 8 hrs = 388 ml/hr for first 8 hours
= 194ml/ hr for the next 16 hours
47
ANY QUESTIONS?!?!
48
16
3/16/2023
THANK YOU!
49
- FENTANYL INFUSION
Add 500mcg Fentanyl (10ml or 5 ampules) to 40ml pNSS to make a solution of
500mcg Fentanyl in 50ml (Fentanyl 10mcg/ml). Run at 0.2mcg/hr =
10mcg/hr
- DEXMEDETOMIDINE INFUSION
Add 2ml of Precedex (200mcg) to 48ml pNSS to make a Precedex Solution
200mcg in 50ml pNSS (or 4mcg/ml).
Start Precedex infusion at 0.5mcg/kg/hr or 25mcg/hr
50
17