STAGES of

DEVELOPMENT THE
mother
BREAST DEVELOPMENT

The development of the breast during a woman's life is characterized by different

phases.
ELC-induced growth regression begins when the infant is initiated on complementary
feeding and ends when the breast has involuted to the resting state. The full
development of the breast during lactation is essential to provide the adequate
volume and composition of breast milk for the growth, protection and development of
the infant.

development fetal

Embryonic development of the breast begins before the sixth week of gestation from a thickening of the
ectodermal ridge that extends from the groin to the axilla on the anterior surface of the embryo. The
appearance of the mammary buds does not change significantly until 13-20 weeks, when a depression forms on
their surface and the proliferation of different populations of epithelial progenitor cells causes the formation
and branching of secondary buds. In the last 8 weeks of gestation, the density of the periductal stroma
increases along with limited lobulo-alveolar development.

Neonatal and prepubertal

development

Until early childhood, the mammary gland remains in an

immature quiescent state, with minimal development and
virtually identical structure in males and females .

Puberty

Puberty induces rapid breast growth, fueled by ovulation and the establishment of regular
menstrual cycles. The increase in the size of the breasts is mainly due to a greater deposition of
adipose tissue inside the gland. Review of the anatomy of the female breast 5 groups called
lobules. Normally, the mini breast remodeling that occurs with each menstrual cycle does not
completely subside by the end of the cycle. Lobe 1, consisting of about 11 ductules;
Lobe 2, of about 47 ductules; and Lobe 3, of approximately 80 ductules.

Pregnancy

Although a mini-remodeling of the breast occurs with each menstrual cycle, it is not until the cycle of pregnancy and
lactation that a complete remodeling of the breast occurs, gradually transforming it into a mature and fully functional
organ. This remodeling works through changes in circulating hormonal complexes that activate populations of The
maturation phases are directly regulated by the increase in circulating lactogenic hormonal complex that induces ductal
branching, alveolar morphogenesis, and secretory differentiation.

Lactation

Secretory activation allows a rapid upregulation of milk synthesis and normally occurs 48-72 hours after calving, triggered by a decrease in blood progesterone and an
increase in prolactin levels. For example, it is well established that the clotting rate in the baby's stomach of infant formulas made from cow's milk, higher than that of
breast milk, is associated with slower gastric emptying and different colonization of the stomach. intestine compared to breastfed babies. Some studies with cattle
suggest that there is a relationship with increased plasma estrogen levels. The possibility can be raised that the increase in factors that induce proliferation during
pregnancy counteracts the factors that induce milk synthesis, since both exert antagonistic effects.

REFERENCIAS
"McPherson, K., Steel, C. M., & Dixon, J. M. (2000). Breast cancer—epidemiology, risk
factors, and genetics. BMJ : British Medical Journal, 321(7261), 624–628.

Sánchez Basurto, C. (2010). Tratado de las enfermedades de la glándula mamaria. Volúmen

1. Editorial Alfil, S. A. de C. V.UNAD

Paola Quintana Torrado