Amoeba Sisters Video Recap: DNA Replication

1. To understand DNA replication, we need to understand
the “why.” Why does DNA need to replicate before cells
divide?
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To make two different types of cells out of the same
DNA during cell division.
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In the below DNA diagram, label ONE of each bolded term:
2. Deoxyribose (sugar). Total number in image? _________
6
3. Nitrogenous base. Total number in image? ___________
6
4. Hydrogen bond. Total number in image? _____________
3
5. Phosphate.
6. Label 5’ to 3’ strand and 3’ to 5’ strand.

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3. DNA Replication has many key players! These are just a few of the major key player enzymes. In your own words,
describe each of their functions in DNA replication.

Helicase:____________________________________________________________________________________________
Break through hydrogen bonds

Builder of new DNA strands

DNA Polymerase:_____________________________________________________________________________________

Starter for DNA Polymerase

Primase:____________________________________________________________________________________________

Ligase:______________________________________________________________________________________________
The glue to patch up unfinished work that the bottom line of DNA Polymerase missed
Your turn to narrate! Narrate the illustrations below to explain the sequence of events occurring in DNA replication.
4.
The Helicase clears the path, breaking through'
the bonds to open up space.

5.
This makes SBP able to go on different sides,
those should never touch, and look, here the
primase!

6.
The Primase does a wonderful job, giving the DNA
Polymerase the exact location to start construction.

7. Leading strand
BUT WAIT! The DP on the bottom are making gaps!
This is horrific, outrageous, this is... oh wait. False
alarm, ligase to the rescue. With his amazing gluing
skills, all is well. Close one!

Lagging strand

8. Label the leading and lagging strands in the last picture. Explain what is meant by the “lagging” strand and why this occurs.
Lagging strands occur when the DP on the bottom will have to go backwards, allowing gaps of his unfinished work.