 VACCINE - an antigenic substance prepared from the

causative agent of a disease or a synthetic substitute,

used to provide immunity against one or several
diseases.
 No. of children immunized
1. Vaccine coverage = --------------------------------------------- x 100
Total no. of children

Attack rate among Attack rate among

Unimmunized _ immunized
2. Vaccine efficacy rate = -----------------------------------------------------x 100
Attack rate among Unimmunized
 DPT1&OPV1 - DPT3&OPV3
3. Drop-out rate =-- --------------------------------------x 100
DPT1&OPV1
1. Following a measles outbreak in Muthanallur village, a survey revealed the
findings:
No. of preschool children = 200
No. of children who have had measles immunization= 100
No. of children with measles disease Among immunized= 10
Among unimmunized= 90
Calculate vaccine coverage and vaccine efficacy rate.
 No. of children immunized
1. Vaccine coverage = ------------------------------------------ x100
Total no. of children

100
= --------------x 100
200
= 50 %

Attack rate among Attack rate among

Unimmunized _ immunized
Vaccine efficacy rate = --------------------------------------------x 100
Attack rate among Unimmunized

90/100 - 10/100
= -------------------------- x 100
90/100

= 88.88%
2. Following is the data for calculation of vaccine coverage and
Vaccine efficacy of pneumococcal vaccine.
Total vaccinated children= 7500
Total unvaccinated children= 2500
Total under five children= 10000
The distribution of cases Among vaccinated= 16
Among unvaccinated= 68
3. Following a measles outbreak in Muthanalluru village, a
survey revealed the findings;
No. of preschool children = 300
No. of children who have had measles immunization= 220
No. of children with measles disease Among immunized= 15
Among unimmunized= 25
Calculate vaccine coverage and vaccine efficacy rate.
4. Following a measles outbreak in Puttenahalli, a survey
revealed the findings;
No. of preschool children = 1000
No. of children who have had measles immunization= 800
No. of children with measles disease
Among immunized= 25
Among unimmunized= 50
Calculate vaccine coverage and vaccine efficacy rate.
5. In Muthanallur village, the immunization coverage of infants
is as follows:
Total no. of infants =50
BCG vaccine=49 DPT1, OPV1 =47
DPT2, OPV2 =46 DPT3, OPV3 =42
Measles = 38
Calculate the drop-out rate and enumerate the possible reasons
for it.
 DPT1&OPV1 ---DPT3&OPV3
5. Drop-out rate =-- -----------------------------------------x 100
DPT1&OPV1

47 ---42
= ----------------x 100
47

= 10.6 %
Reasons:
Ignorance
Lack of proper information/health education
Poverty
Lack of transport
Myths
6. In Puttenahalli UHTC, the immunization coverage of infants
is as follows:
Total no. of infants =220
BCG vaccine=210
DPT1, OPV1 =190
DPT2, OPV2 =170
DPT3, OPV3 =150
Measles = 140
Calculate the drop-out rate and enumerate the possible reasons
for it.
7. In Puttenahalli UHTC, the immunization coverage of infants
is as follows:
Total no. of infants =250
BCG vaccine=245
DPT1, OPV1 =240
DPT2,OPV2 =230
DPT3, OPV3 =220
Measles = 210
Calculate the drop-out rate and enumerate the possible reasons
for it.
8. In Puttenahalli UHTC, the immunization coverage of infants
is as follows:
Total no. of infants =280
BCG vaccine=270
DPT1, OPV1 =260
DPT2, OPV2 =250
DPT3, OPV3 =220
Measles = 210
Calculate the drop-out rate and enumerate the possible reasons
for it.
9. The population of Puttenahalli is 50000
Birth rate = 30 /1000 population
Infant mortality rate = 100 / 1000 live births
Estimate the requirement of tetanus toxoid, BCG and DPT
vaccine for the area annually.
10. The population of Puttenahalli is 40000
Birth rate = 20 /1000 population
Infant mortality rate = 70 / 1000 live births
Estimate the requirement of tetanus toxoid, BCG and DPT
vaccine for the area annually
No. of pregnant women = population x Birth rate
= 50000x 30 /1000 = 1500
Requirement of TT vaccine = 2 doses per woman
Total TT doses =no. of pregnant women x no. of dosages x WMF
= 1500 x 2 x 1.33 = 3990
One vial contains 10 doses
No. of vials required annually = 399 vials
DPT vaccine
No. of infants at 1 yr of age= population x Birth rate x (1- infant
mortality rate)
= 50000 x 30 / 1000 x (1 – 100/1000)
= 1350
Requirement of DPT per infant------3 doses
Total DPT doses = 1350 x 3 x 1.33= 5387 doses

No. of vials = 5387/10 = 539 vials

BCG /Measles
Total BCG/Measles doses= no. of infants x no. of dosages x WMF

= 1350 x 1 x 2 = 2700
No. of vials for BCG = 2700/ 20 =135 vials
No. of vials for Measles = 2700/5 = 540 vials.