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    Luis Fernando Zhinin
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    The letter submits a research article entitled "A Hybrid Approach Based on R-CNN ResNet-50 Pre-trained and Image Segmentation Algorithm to Detect Glaucoma Using Fundus Image" for publication consideration. The article aims to use a hybrid method combining pre-trained R-CNN ResNet-50 and cup-to-disk area segmentation to localize glaucoma in fundus images. Evaluating ResNet50 showed an average confidence of 0.879, indicating it is reliable for glaucoma detection. An overall accuracy of 95% was achieved. The authors believe the manuscript is appropriate for the journal as it provides a new trustworthy approach for glaucoma diagnosis using fundus images.

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    The letter submits a research article entitled "A Hybrid Approach Based on R-CNN ResNet-50 Pre-trained and Image Segmentation Algorithm to Detect Glaucoma Using Fundus Image" for publication consideration. The article aims to use a hybrid method combining pre-trained R-CNN ResNet-50 and cup-to-disk area segmentation to localize glaucoma in fundus images. Evaluating ResNet50 showed an average confidence of 0.879, indicating it is reliable for glaucoma detection. An overall accuracy of 95% was achieved. The authors believe the manuscript is appropriate for the journal as it provides a new trustworthy approach for glaucoma diagnosis using fundus images.

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    6 views1 page

    Cover Letter - Example

    Uploaded by

    Luis Fernando Zhinin
    The letter submits a research article entitled "A Hybrid Approach Based on R-CNN ResNet-50 Pre-trained and Image Segmentation Algorithm to Detect Glaucoma Using Fundus Image" for publication consideration. The article aims to use a hybrid method combining pre-trained R-CNN ResNet-50 and cup-to-disk area segmentation to localize glaucoma in fundus images. Evaluating ResNet50 showed an average confidence of 0.879, indicating it is reliable for glaucoma detection. An overall accuracy of 95% was achieved. The authors believe the manuscript is appropriate for the journal as it provides a new trustworthy approach for glaucoma diagnosis using fundus images.

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    of 1

    Luis Zhinin-Vera

    Universidad Castilla-La Mancha


    Albacete, Spain
    luis.zhinin@uclm.es

    Prof. Jinan Fiaidhi


    Editor-in-Chief
    Journal of Advances in Information Technology

    April 24, 2023

    Dear Dr. Editorian:

    I am pleased to submit the article entitled “A Hybrid Approach Based on R-CNN ResNet-50 Pre-trained and Image
    Segmentation Algorithm to Detect Glaucoma Using Fundus Image” by Marlene Puchaicela, Ana Andrade, Dayanna
    Baque, Carolina Cadena, Andrés Tirado, Lenin Ramírez, Diego Almeida-Galárraga, Jonathan Cruz and Fernando
    Villalba-Meneses for consideration and publication in the Journal of Advances in Information Technology.

    This work aims to use a hybrid method for glaucoma fundus image localization with pre-trained R-CNN ResNet-50
    and cup-to-disk area segmentation. For which the ACRIMA and ORIGA databases were used that contain fundus
    images. As a result, evaluating the ResNet50 shows average confidence of 0.879, which means that the
    convolutional neural network is a reliable alternative for glaucoma detection. The final accuracy of 95% was
    obtained. In addition, the validation loss plot indicates that for five epochs, ResNet50 achieved an appropriate fit
    due to the application of the transfer learning concept.

    We believe this manuscript is appropriate for publication in the Journal of Advances in Information Technology, as it
    provides a new trustworthy approach for the safe diagnosis of glaucoma using fundus images. Here also, the cup-to-
    disc ratio is calculated by using Gradient-color-based optic disc segmentation. The algorithm coincided with the
    Resnet50 results in 80% of cases, having an average confidence score of 0.84. Therefore, considering both results, it
    can be determined whether there is glaucoma or not.

    This manuscript has not been published and is not under consideration for publication elsewhere. We have no
    conflicts of interest to disclose.

    In addition, we declare that all authors have made substantial contributions to all of the following: (1) conception
    and design of the study, (2) drafting of the article or critical revision for important intellectual content, (3) final
    approval of the version to be submitted.

    Thank you for your consideration!

    Sincerely,

    Luis Zhinin-Vera
    Universidad Castilla-La Mancha – Spain

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