CASE STUDY OF THALASSEMIA

ASSIGNMENT HEMOTOLOGY AND BLOOD BANKING

SUBMITTED BY:
NAUMAN ARSHAD (70092971)

SUBMITTED TO:
SIR REHMAN

SEMESTER:
9th

SECTION:
B

UNIVERSITY INSTITUTE OF MEDICAL LAB TECHANOLOGY THE

UNIVERSITY OF LAHORE RAIWIND ROAD CAMPUS LAHORE

Submitted By: NAUMAN ARSHAD

 CASE STUDY OF THALASSEMIA

INTRODUCATION:
According to a report approximately 100,000 patients are suffering from Thalassaemia in Pakistan
and every year 5,000 babies are born with this deadly disease. These patients needs regular blood
transfusion and iron chelation after consultation with a qualified Hematologist along with regular
diagnostic investigations on monthly basis which is unaffordable by the poor families in Pakistan.

FINDINGS:
This case study describes a 5-year-old male diagnosed Thalassaemia in 2022. He had a very low
hb, but his parents were not sure when he contracted it. The child also had symptoms related to the
infections on cbc report. He has never received any treatment for his Thalassaemia.

PATIENT PRESENTATION:

PAST MEDICAL HISTORY:

Anemia, weight loss

SURGICAL HISTORY:
None

PHYSICAL EXAMINATION:
Vital Signs

Temp 98.8°F, P 82 bpm, RR 18 breaths per minute,

ABDOMEN:
Soft, non-distended, non-tender, normal bowel sounds

GENITOURINARY:
No complaints of dysuria or hematuria
LABORATORY FINDINGS:
Patient name Azeez Ul Rehman has a CBC report and parameters show some complexity.

Submitted By: NAUMAN ARSHAD

 COMPLETE BLOOD COUNT TEST:

TEST REFERANCE VALUE UNIT RESULT

Hb 13-18 g/dl 6.3

Total RBC 4.5-6.5 ×10ˆ12/L 2.41

HCT 38-52 % 20.0

MCV 75-95 fl 83.4

MHC 26-32 pg 26.1

MHCH 30-35 g/dl 31.5

RDW CV % 11.5-14.5 % 15.4

Platelet Count 150-400 ×10ˆ9/L 420

MPV fl 7-11 fl 8.4

WBC Count (TLC) 4-11 ×10ˆ9/L 45.1

Lymphocytes 20-50 % 56.6

Submitted By: NAUMAN ARSHAD

 INTERPRETATION:

Hb 13-18 g/dl 6.3

The patient has Abnormal Hb value.

WHAT IS THIS TEST?

A hemoglobin test measures the levels of hemoglobin in your blood. Hemoglobin is a protein in
your red blood cells that carries oxygen from your lungs to the rest of your body. If your
hemoglobin levels are abnormal, it may be a sign that you have a blood disorder.

Other names: Hb, Hgb

Total RBC 4.5-6.5 ×10ˆ12/L 2.41

The patient has Abnormal Total RBC value.

WHAT IS THIS TEST?

The test can help diagnose different kinds of anemia (low number of RBCs) and other conditions
affecting red blood cells.

Other conditions that may require an RBC count are:

 Disease that damages kidney blood vessels (Alport syndrome)

 White blood cell cancer
 Disorder in which red blood cells break down earlier than normal
 Bone marrow disorder in which the marrow is replaced by scar tissue

HCT 38-52 % 20.0

The patient has Normal HCT value.

Submitted By: NAUMAN ARSHAD

 WHAT IS THIS TEST?
Hematocrit (HCT) is the calculated volume percentage of red blood cells (erythrocytes) in your
blood. Hematocrit is also called packed cell volume (PCV) or erythrocyte volume fraction. Human
blood contains red blood cells, white blood cells, and platelets suspended in a liquid called plasma.

MCV 75-95 fl 83.4

The patient has Abnormal MCV value.

WHAT IS THIS TEST?

MCV stands for mean corpuscular volume. There are three main types of corpuscles (blood cells)
in your blood–red blood cells, white blood cells, and platelets. An MCV blood testmeasures the
average size of your red blood cells, also known as erythrocytes.

MHC 26-32 pg 26.1

The patient has Normal MHC value.

WHAT IS THIS TEST?

Major histocompatibility complex (MHC), group of genes that code for proteins found on the
surfaces of cells that help the immune system recognize foreign substances. MHC proteins are
found in all higher vertebrates. In human beings the complex is also called the human leukocyte
antigen (HLA) system.

MHCH 30-35 g/dl 31.5

The patient has Normal MHCH value.

WHAT IS THIS TEST?

MCHC stands for mean corpuscular hemoglobin concentration. It’s a measure of the average
concentration of hemoglobin inside a single red blood cell. MCHC is commonly ordered as part
of a complete blood count (CBC) panel.

Submitted By: NAUMAN ARSHAD

RDW CV % 11.5-14.5 % 15.4

The patient has Abnormal RDW CV % value.

WHAT IS THIS TEST?

The red cell distribution width (RDW) blood test measures the amount of red blood cell variation
in volume and size.You need red blood cells to carry oxygen from your lungs to every part of your
body. Anything outside of the normal range in red blood cell width or volume indicates a possible
problem with bodily function that in turn may affect oxygen getting to various parts of your
body.However, with certain diseases, you may still have a normal RDW.

Platelet Count 150-400 ×10ˆ9/L 420

The patient has Abnormal Platelet Count value.

WHAT IS THIS TEST?

A normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. Having
more than 450,000 platelets is a condition called thrombocytosis; having less than 150,000 is
known as thrombocytopenia. You get your platelet number from a routine blood test called a
complete blood count (CBC).

Lymphocytes 20-50 % 56.6

The patient has Normal Lymphocytes value.

WHAT IS THIS TEST?

Lymphocyte count is one part of a complete blood count (CBC), which is a larger whole blood
test. Doctors may request a CBC if they suspect that a disease or infection is present. The test can
also use a sample of the bone marrow instead of blood in some cases.

Submitted By: NAUMAN ARSHAD

MPV fl 7-11 fl 8.4

The patient has Abnormal MPV fl value.

WHAT IS THIS TEST?

MPV stands for mean platelet volume. Platelets are small blood cells that are essential for blood
clotting, the process that helps you stop bleeding after an injury. An MPV blood test measures the
average size of your platelets. The test can help diagnose bleeding disorders and diseases of the
bone marrow.

Other names: Mean Platelet Volume

WBC Count (TLC) 4-11 ×10ˆ9/L 45.1

The patient has Normal WBC Count (TLC) value.

WHAT IS THIS TEST?

TLC or WBC count is a blood test that evaluates the number of WBC (white blood cells), also
known as leukocytes. The leukocytes are the essential parts of our defense mechanism as they fight
with infections. It is one of the tests among complete blood count (CBC), which is often used in
the general evaluation of your overall health. Blood is a fluid connective tissue made up of three
types of cells suspended in a fluid known as plasma. WBC, RBC, and platelets are the types of
cells that originate from bone marrow and circulates in the bloodstream.

Submitted By: NAUMAN ARSHAD

Submitted By: NAUMAN ARSHAD
REFRENCES:
 ALL DATA IS COLLECTED FROM SIR GANGA RAM HOSPITAL,
MAJOR LAB, HEMATOLOGY DEPARTMENT.

Submitted By: NAUMAN ARSHAD