Carbosulfan | 55285-14-8 https://www.chemicalbook.com/ChemicalProductProperty_EN_CB2739296.

htm

Properties Safety Price 2 Uses Spectrum Request For Quotation

Carbosulfan Structure Search
Carbosulfan

ChemicalBook >> CAS DataBase List >>Carbosulfan

Carbosulfan
Chemical properties Application Preparation Method Category Toxicity classification Acute toxicity Flammability

Hazard Characteristics Storage and transportation Extinguisher

CAS No. 55285-14-8

Chemical Name: Carbosulfan

Synonyms DBSC;Posse;BRIGHT;Versal;AMITAGE;MARSH
AL;Sheriff;POSSE(R);AGROSTAR;CARBOFAN

CBNumber: CB2739296

Molecular Formula: C20H32N2O3S

Formula Weight: 380.54

MOL File: 55285-14-8.mol

Carbosulfan structure
Request For Quotation

1 of 7 10/14/2021, 3:07 PM
Carbosulfan | 55285-14-8 https://www.chemicalbook.com/ChemicalProductProperty_EN_CB2739296.htm

Carbosulfan
Properties Properties
Safety Price 2 Uses Spectrum Request For Quotation

Melting point: <25 °C

Boiling point: approximate 126℃

Density 1.0560

vapor pressure 3.1 x 10-5 Pa (20 °C)

refractive index 1.6360 (estimate)

Flash point: 96 °C

storage temp. 0-6°C

pka 3.15±0.70(Predicted)

Water Solubility 0.3 mg l-1 (25 °C)

form neat

Merck 13,1836

CAS DataBase Reference 55285-14-8(CAS DataBase Reference)

FDA UNII V1DGN4AK6G

NIST Chemistry Reference Carbamic acid, [(dibutylamino)thio]methyl-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl

ester(55285-14-8)

EPA Substance Registry Carbosulfan (55285-14-8)

System

SAFETY Risk and Safety Statements

Symbol(GHS)
GHS06,GHS09

Signal word Danger

Hazard statements H301-H317-H330-H410

Precautionary statements P260-P273-P280-P284-P301+P310-P310

2 of 7 10/14/2021, 3:07 PM
Carbosulfan | 55285-14-8 https://www.chemicalbook.com/ChemicalProductProperty_EN_CB2739296.htm

Hazard Codes T;N,N,T,T+

Properties Safety Price 2 Uses Spectrum Request For Quotation
Risk Statements 23/25-43-50/53-26-25

Safety Statements 24-37-38-45-60-61-63-36/37-28

RIDADR UN 2810

WGK Germany 3

RTECS EZ3815000

HazardClass 6.1(b)

PackingGroup III

LD50 in male, female rats (mg/kg): 250, 185

orally; in male, female rabbits (mg/kg): >2000,
Toxicity >2000 dermally; in pheasant, mallard, quail
(ppm): 26.2, 8.1, 81.6 orally. LC50 (96 hr) in
bluegill, trout (ppb): 14.9, 42.4 (Maitlen).

Carbosulfan price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy

Sigma-Aldrich 32005 Carbosulfan PESTANAL 55285-14-8 100mg $86.6 2021-03-22 Buy

Sigma-Aldrich N11409 Carbosulfan analytical standard 55285-14-8 250mg $120 2020-08-18 Buy

Carbosulfan Chemical Properties,Uses,Production

Chemical properties
Brown sticky liquid. B.p. is124 ~ 128 ℃ (114 ℃). The flash point is 115~1,117℃, and the vapor pressure is 0.041 x 10-3Pa. The relative density is 1.056 (20℃). It can
dissolve with acetone, ethanol and xylene, and the solubility in water is 0.3mg/L. The distribution coefficient is 157 (pH value is 7.05).
It has a fast decomposition in water, easily decomposed into carbofuran with pH<7. In the sun, when the 5 g/mL of Carbosulfan is in buffer solution with pH equaling to 7,
the half-life period is 1.4d and 4 ~ 8d in distilled water.

Application
This product is a derivative of carbofuran, which has the same insecticidal activity as carbofuran .But its toxicity is much lower than carbofuran, a stomach insecticide .It
can be metabolized into carbofuran in the organism and then play its effect to kill the insect. It has excellent control effect on the potato green peach aphid, black beetle,
high dyed blind fly, cutworm and other insects. In addition, it can also better control cotton spider mite, billbug, tribolium confusum and spodoptera moth etc..
Carbamate insecticides, acaridants and nematides with high absorbability and broad-spectrum properties. It is a low toxic variety of Carbosulfan for the control of citrus,

3 of 7 10/14/2021, 3:07 PM
Carbosulfan | 55285-14-8 https://www.chemicalbook.com/ChemicalProductProperty_EN_CB2739296.htm

fruit trees, cotton and rice crops of aphids, mites, wireworm, beet and potato beetles, a hidden food tea leafhopper, Grapholitha molesta, codling moth and other pests.
The Properties Safety
administration concentration is 5mg/L and Price 2
the effective Usesis 6.8 ~ 15gSpectrum
component /100m2. Request For Quotation
Low toxic insecticides with internal absorbability and broad-spectrum
For the control of rust ticks, aphids, thrips, leafhoppers and other more than 10 kinds of pests on the fruit trees, cotton, vegetables, grain and other crops.

Preparation Method
Preparation method 1:
Preparation of two n-butanamine sulphide Add two n-butyl amine and petroleum ether (60~90℃ ), mixing and cooling to 0℃ . Then slowly drip disulfur dichloride and
maintain the temperature at 0~10 ℃. Afterwards, the reaction will be maintained at a constant temperature. The proportioning of the di-n-butylamine, disulfur dichloride
and sulfuric chloride is 1:0.6:0.55(mol). The yield is 88%.
The synthesis of carbosulfan Two n-butanamine sulphur chloride reacts with carbosulfan with the ratio of 1:1. The reaction process is added with a proper amount of
alkaline solution, and the reaction temperature is 10~20 ℃. The reaction time period is 2h. Add water and mix it for 10 minutes after the reaction. Filter it and the
unreacted is carbosulfan which can be reused. The filtrate is stratified and the oil layer is decompressed and dissolving, and the yield is 90%.

Preparation method 2:
The synthesis of the intermediates hydroxyl compounds can be take the carbosulfan as reference. There are also literature reporting that starting from cyclohexanone
and isobutyrate, five steps will be able to get it synthesized through condensation, chlorination, aromatization, hydrolysis and closed loop reaction. It is characterized by
the synthesis of non aromatic compounds and is a highly selective synthesis route.

Category
Pesticides

Toxicity classification
Highly toxic

Acute toxicity
Oral administration-rats LD50: 51 mg / kg;
Oral administration - mouse LD50: 74 mg / kg

Flammability
Combustible

Hazard Characteristics
Combustion can produce toxic nitrogen oxides and oxygen sulfide.

Storage and transportation

The storeroom is ventilated and dry at low temperature.
Separate transportation from food raw materials.

Extinguisher
Dry powder, foam, sand.

4 of 7 10/14/2021, 3:07 PM
Carbosulfan | 55285-14-8 https://www.chemicalbook.com/ChemicalProductProperty_EN_CB2739296.htm

Properties
Description Safety Price 2 Uses Spectrum Request For Quotation
Carbosulfan (8)，2,3-dihydro-2,2-dimethylbenzofuran- 7-yl(dibutylaminothio)methylcarbamate(IUPAC), is an orange to brown, clear viscous liquid (bp 124–128 ?C),
miscible with organic solvents and solubility 0.3 ppm in water(25 ?C). It is closely related structurally to carbofuran,and like carbofuran, it is a cholinesterase inhibitor with
systemic activity.

Chemical Properties
Orange-yellow thick liquid.

Uses
Carbosulfan is an insecticide with contact and stomach action. It is used to control a wide range of soil-dwelling and foliar pests in cotton, sugar beet, potato, rice, fruit,
maize, vegetables, sugar cane and coffee.

General Description
Viscous brown liquid.

Air & Water Reactions

Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by
acids.

Reactivity Profile
Carbosulfan is a thiocarbamate. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides.
Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides.

Potential Exposure
Carbosulfan is a carbamate insecticide and a low toxic derivative from cabofuran. It is a broad spectrum insecticide, nematicide, miticide, effective against pests and
mites. It is used to protect alfalfa, apple, citrus, corn, deciduous fruit, potato, rice, sorghum, soybean, sugar beets, sugarcane, and other vegetable, field, tree and
orchard crops. It is used for seed treatments

Metabolic pathway
Carbosulfan is an N-sulfenyl-N-methylcarbamate which is effectively a pro-insecticide of carbofuran. The latter is formed in vivo by the biochemical or chemical thiolysis
of carbosulfan. N-S Bond cleavage, oxidation, conjugation and hydrolysis are the main metabolic routes for carbosulfan in plants and animals. Carbosulfan is degraded
via carbofuran in soil. In plants, carbosulfan is metabolised via carbofuran to 3-hydroxycarbofuran (PM).

Metabolism
Itsmetabolic patterns are similar to those of carbofuran. In rats, it rapidly undergoes hydrolytic and oxidative processes followed by conjugation. It is not persistent in
soils, with DT50 ca. 2–5 days, and it was rapidly degraded to carbofuran in a sandy loam soil (4). Carbofuran was subsequently hydrolyzed at the carbamate ester group
to form the phenol carbofuran or oxidized at the 3- position. Biscarbofuran disulfide and minor products were also detected. Carbofuran was also formed in soils by
nonbiological degradation processes.

Shipping

5 of 7 10/14/2021, 3:07 PM
Carbosulfan | 55285-14-8 https://www.chemicalbook.com/ChemicalProductProperty_EN_CB2739296.htm

UN2992 Carbamate pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials; UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-
Properties
Poisonous Safety
materials, Technical Price 2
Name Required. Uses Spectrum Request For Quotation

Degradation
Carbosulfan is hydrolysed in aqueous media most rapidly under acidic conditions. Its DT50 values (25 °C) at pH 4,6 and 7 were <1 hour, 22 hours and 7.6 days
respectively (PM). In a variety of aqueous solvents there was facile cleavage of the N-S carbamate bond of carbosulfan to yield carbofuran (2) as the sole or major
product (see Scheme 1) (Umetsu et al., 1980). A solution of [14C]carbosulfanin propylene glycol was treated with 0.001 or 0.01 N aqueous HCl at 40 °C. Solutions were
analysed at intervals up to 24 hours. Carbosulfan was relatively stable with more than 40% being recovered after 24 hours in the solution of lower acidity. Carbofuran (2)
was the principal transformation product in hydrochloric acid. Biscarbofuran disulfide (3) was present in only trace amounts and small amounts of polysulfides of
carbosulfan (4,n = 2-6) were detected (Umetsu and Fukuto, 1982).
Carbosulfan was quite stable in neutral and alkaline media. [14C-carbonyl]- or [14C-dibutylamino]Carbosulfan dissolved in dichloromethane: acetic acid (9:l) converted to
a range of products via N-S bond cleavage. The principal products were carbofuran (2), dibutylamine and a mixture of polysulfide derivatives: bis-carbofuran disulfide (3)
and a mixture of bis-carbofuran polysulfides (5). Structures of products were confirmed by MS and NMR (Umetsu et al., 1981a,b).

Incompatibilities
Carbamates are incompatible with strong oxidizing acids, peroxides, and hydro-peroxides; strong reducing agents such as hydrides; strong acids and bases. Contact
with nitrides or chemically active metals (aluminum, copper, magnesium, neptunium, sodium, tin, titanium,zinc, etc.) causes the release of potentially explosive hydrogen
gas and a metal salt.

Waste Disposal
Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with
environmental regulatory agencies for guidance on acceptable disposal practices. Incineration with effluent gas scrubbing is recommended. In accordance with
40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Noncombustible containers should be crushed and buried under more than
40 cm of soil. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your
regional EPA office.

Carbosulfan Preparation Products And Raw materials

Raw materials
Disulfur dichloride Carbofuran Sulfuryl chloride Sulfur dichloride Cyclohexanone Isobutyraldehyde Dibutylamine PETROLEUM ETHER
DIBUTYL AMIDOSULFENYL CHLORIDE BIS(DIBUTYLAMINO)DISULFIDE

Preparation Products
CARBOFURAN-3-HYDROXY

Carbosulfan Spectrum
Carbosulfan(55285-14-8) IR1 Carbosulfan(55285-14-8) MS

6 of 7 10/14/2021, 3:07 PM
Carbosulfan | 55285-14-8 https://www.chemicalbook.com/ChemicalProductProperty_EN_CB2739296.htm

55285-14-8(Carbosulfan)Related
Properties Safety Price 2 Search:
Uses Spectrum Request For Quotation
Abamectin+Carbosulfan,E.C. Dichlorovos+Carbosulfan,E.C. (35%) Carbosulfan+Triazophos,E.C. CARBOSULFAN SOLUTION 100UG/ML TOLUENE 1ML
Carbosulfan+Triphosphorustin,E.C. Carbosulfan+Triadimefon,seed coating Carbosulfan+Phoxim,E.C. Imidacloprid+Carbosulfan,E.C.(20%)
Carbosulfan+Petroleum oil,E.C.(30%) Pyridaben+Carbosulfan,E.C. CARBOSULFAN, 1 X 100MG, NEAT o-hydroxyphenyl methylcarbamate
o-hydroxyphenyl carbamate 2,3-Dihydro-2,2-dimethyl-7-benzofuranol POLYURETHANE 2,6-Dimethyl-7-octen-2-ol Methyl 4-tert-butylbenzoate
Carbofuran

((dibutylamino)thio)methylcarbamicacid,2,2-dimethyl-2,3-dihydro-7-benzofura POSSE(R) ADVANTAGE(R) AGROSTAR AMITAGE

2,3-DIHYDRO-2,2-DIMETHYL-7-BENZOFURANYL)-N-DIBUTYLAMINTHIO-N-METHYL-CARBAMATE
2,3-DIHYDRO-2,2-DIMETYL-7-BENZOFURANYL-[(DIBUTYLAMINO)THIO]METHYLCARBAMATE
2,3-DIHYDRO-2,2-DIMETHYLBENZOFURAN-7-YL (DIBUTYLAMINOTHIO)METHYLCARBAMATE GAZELLE(R) CARBOSHELL CARBOSULFAN
BRIGHT MARSHAL(R) MARSHAL 2,3-Dihydro-2,2-dimethyl-7-benzofuran-N-(2-n-butylaminothio)-N-methylcarbamate
CARBOSULFAN, 1 X 250MG, NEAT CARBOSULFAN PESTANAL, 250 MG
CARBOSULFAN,(2,3- DIHYDRO -2,2- DIMETHYL -7- BENZOFURANYL) -N- DIBUTYLAMINTHIO -N- METHYL -CARBAMATE CARBOFAN
carbosulfan (bsi,ansi,iso) dibutylaminosulfenylcarbofuran CARBOSULPHAN 2,3-dihydro-2,2-dimethyl-7-benzofuryl [(dibutylamino)thio]methylcarbamate
Adrantage 2,3-dihydro-2,2-dimethyl-7-benzofuryl [(dibutylamino)thio]methylcarbamate carbosulfan Carbosulfan E.C.
2，3-dihydro-2,2-dimethylbenzofruan-7-yl (dibutyl aminothio) methyl-carbamate Advantange
2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-yl (dibutylamino)sulfanyl(methyl)carbamate 2,3-dihydro-2,2-dimethyl-7-benzofuranyl((dibutylamino)thio)methylcarbamate
2,3-dihydro-2,2-dimethyl-7-benzofuranyl(di-n-butylaminosulfenyl)methylcarbam 2,3-Dihydro-2,2-dimethyl-7-benzofuranyl[(dibutylamino)thio]methyl carbamate
Advantage Carbamic acid, [(dibutylamino)thio]methyl-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester
carbamicacid,((dibutylamino)thio)methyl-,2,2-dimethyl-2,3-dihydro-7-benzofur FMC 35001 fmc35001 Marshal 10G Marshal/suscon marshall
Marshall 10G OMS 3022 Posse Sheriff DBSC N-(Dibutylaminothio)-N-methylcarbamic acid 2,3-dihydro-2,2-dimethylbenzofuran-7-yl
Carbosulfan Standard N-[(DibutylaMino)thio]-N-MethylcarbaMic Acid 2,3-Dihydro-2,2-diMethyl -7-benzofuranyl Ester Versal Zaprawa Marshal Carbosulran
((dibutylamino)thio)methylca Carbosulfan Solution, 1000ppm N-(2,2-dimethyl-3H-benzofuran-7-yl)-N-methylcarbamic acid [(dibutylamino)thio] ester
Carbosulfan @100 μg/mL in MeOH Carbamic acid, N-[(dibutylamino)thio]-N-methyl-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester
Carbosulfan Solution in Acetone,100μg/mL 55285-14-8

Copyright 2017 © ChemicalBook. All rights reserved

7 of 7 10/14/2021, 3:07 PM