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Principle, Construction, Working, Uses, Merits and Demerits of Freeze Dryer - Pharmaguideline
Principle, Construction, Working, Uses, Merits and Demerits of Freeze Dryer - Pharmaguideline
Constructions
There are three types of freeze dryers. The tray-style freeze-dryer, the rotary freeze-dryer, and the manifold freeze-dryer are the three types of
freeze-dryers. Each of these methods relies on a vacuum pump to lower the atmosphere pressure in a vessel that holds the substance to be dried
and a condenser to remove moisture through condensation on a surface that is chilled to between 20 and 80°C. Freeze-dried substances are
connected to condensers in three different ways: manifold, rotary, and tray.
An insulated tube connected by a circular bend connects multiple containers filled with dried goods to a condenser.
Within rotary freeze-dryers are large reservoirs used to store drying substances. Pellets, cubes and other liquids are usually dried with
rotary freeze-dryers. The cylindrical reservoir of a rotary dryer rotates during drying so that the substance is evenly dried.
For storing dried materials, a tray freeze-dryer includes a large reservoir. A rectangular reservoir with shelves and trays is usually used to
store pharmaceutical solutions and tissue extracts, which are collected in the reservoir.
In a freeze dryer, products are kept in a vacuum chamber that cools and heats the containers and contents as they are dried. Vacuum chambers are
connected to vacuum pumps, refrigeration units, and electronic controls.
Freeze-drying consists of four important steps: pretreatment, freezing, primary drying, and secondary drying.
Pretreatment - This stage is for determining the freezing point of the product, solution-phase concentration, preserving product appearance,
stabilizing reactive products, reducing the concentration of high-vapor pressure solvents, and increasing surface area before freezing. Sometimes,
pre-treating a product is dictated by cycles time or product quality considerations rather than the knowledge of freeze-drying and its requirements.
Freezing - The liquid sample is cooled down to between 40° C and 60 °C in the freezing stage until parts of it crystallize into pure ice, and the
remainder is freeze-concentrated into a glassy state when the viscosity is too high to permit further crystallization.
Primary drying - A primary dry process removes the ice formed by freezing by sublimating it under vacuum at low temperatures. The resulting
amorphous solute, typically 10% water, has a very porous structure that is highly porous. A pressure of 10 - 4 to 10 - 5 atmospheres is used, and a
temperature of –45 to –20°C is used in this step. Heat and mass are transferred during the sublimation process during primary drying.
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Freeze Dryer
Secondary drying - As the sample is gradually heated between 10 °C and 15 °C while maintaining low pressure, most of the remaining water is
desorbed from the glass. A good cake should be dry, reconstituted easily, and have a low amount of moisture (below 5% weight to weight).
Uses
Vaccines and other injectables are often freeze-dried by pharmaceutical companies in order to increase their shelf life.
Material can be stored, shipped, and later reconstituted into its original form by removing the water and sealing the material in a vial under
vacuum.
By freeze-drying biologicals, it is possible to preserve them and make them lightweight.
The freeze-dried form of blood products is used for preservation.
Often, freeze-dried products are used in chemical synthesis to stabilize them or make them more soluble in water.
By freeze-drying, solvents can be effectively removed that can be used in the final steps of bio-separation.
Furthermore, low molecular weight substances that are too small to be removed by a filtration membrane can be concentrated using this
technique.
Merits
Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of pharmaguideline.com, a widely-read pharmaceutical
blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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