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Substances: triclosan

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Triclosan: applications and safety.

By: Bhargava, H N; Leonard, P A

Triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) is a nonionic, broad spectrum, antimic robial agent that, because of its favorable
safety profile, has been incorporated into a variety of many personal care products, including deodorant soaps, underarm deodor ants,
shower gels, and health care personnel handwashes. Triclosan exhibits a moderate degree of substan tivity to the skin, and, in many
products, it imparts a remnant antimicrobial effect. Although direct contact with the material under exagge rated exposure conditions
causes dermal irritation in laboratory animals, it has only rarely been associated with skin irritation or sensitization in human being in
formulated products. Acute, subacute/subchronic, and chronic toxicity profiles have been establ ished to determine that triclosan is
neither an acute oral toxicant nor that it acts as a carcinogen, mutagen, or teratogen. A new applic ation for triclosan is in oral dentif
rices for plaque control. Currently under investi gation in the United States, it is approved for oral care applic ation in Canada and many
European countries.

Journal

Source Database Information

American journal of infection control PubMed ID: 8807001
Volume: 24 MEDLINE
Issue: 3 Company/Organization
Pages: 209-18 Division of Pharmaceutical Sciences, Massachusetts
Journal; Article College of Pharmacy and Allied Health Sciences,
1996 Boston 02115, USA.
DOI: 10.1016/s0196-6553(96)90017-6 Publisher
Unknown
Language
English

MEDLINE® Medical Subject Headings

Animals
Anti-Infective Agents, Local (Qualifier: administration & dosage ; standards)
Bacteria (Qualifier: drug effects)
Carcinogens
Detergents
Hand Disinfection
Household Products
Humans
Hygiene
Mutagens
Soaps
Teratogens
Triclosan (Qualifier: administration & dosage ; pharmacology; standards; toxicity)

Substances
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1. Triclosan (3380-34-5 )
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