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    PBL - Group 1 - Histoplasmosis

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    Satria Tegar R
    This document discusses histoplasmosis, a fungal infection caused by Histoplama capsulatum. [1] Histoplama capsulatum is found globally and can infect both humans and animals, being found in soil containing bird or bat feces. [2] Clinical symptoms in animals include weight loss, fever, anorexia, respiratory signs, and gastrointestinal issues like diarrhea. [3] Pathological changes seen include blunted and fused villi in the small intestine and the presence of yeasts in macrophages of cutaneous lesions. [4] Treatment options include itraconazole, ketoconazole, and amphotericin B. [5] Diagnosis involves antigen testing of

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    PBL - Group 1 - Histoplasmosis

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    Satria Tegar R
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    This document discusses histoplasmosis, a fungal infection caused by Histoplama capsulatum. [1] Histoplama capsulatum is found globally and can infect both humans and animals, being found in soil containing bird or bat feces. [2] Clinical symptoms in animals include weight loss, fever, anorexia, respiratory signs, and gastrointestinal issues like diarrhea. [3] Pathological changes seen include blunted and fused villi in the small intestine and the presence of yeasts in macrophages of cutaneous lesions. [4] Treatment options include itraconazole, ketoconazole, and amphotericin B. [5] Diagnosis involves antigen testing of

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    This document discusses histoplasmosis, a fungal infection caused by Histoplama capsulatum. [1] Histoplama capsulatum is found globally and can infect both humans and animals, being found in soil containing bird or bat feces. [2] Clinical symptoms in animals include weight loss, fever, anorexia, respiratory signs, and gastrointestinal issues like diarrhea. [3] Pathological changes seen include blunted and fused villi in the small intestine and the presence of yeasts in macrophages of cutaneous lesions. [4] Treatment options include itraconazole, ketoconazole, and amphotericin B. [5] Diagnosis involves antigen testing of

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    © All Rights Reserved
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    8 views10 pages

    PBL - Group 1 - Histoplasmosis

    Uploaded by

    Satria Tegar R
    This document discusses histoplasmosis, a fungal infection caused by Histoplama capsulatum. [1] Histoplama capsulatum is found globally and can infect both humans and animals, being found in soil containing bird or bat feces. [2] Clinical symptoms in animals include weight loss, fever, anorexia, respiratory signs, and gastrointestinal issues like diarrhea. [3] Pathological changes seen include blunted and fused villi in the small intestine and the presence of yeasts in macrophages of cutaneous lesions. [4] Treatment options include itraconazole, ketoconazole, and amphotericin B. [5] Diagnosis involves antigen testing of

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    of 10

    HISTOPLASMOSIS

    CELLIN RUBIANTI AZZHARA B0401201802


    CHOONG XIN TONG B0401201815
    NG VI LYN B0401201816
    KHU ING ZHI B0401201817
    NABILA PUTRI SHARIVA SADAT B0401201839
    SATRIA TEGAR RAHMADANI B0401201840
    INTRODUCTION

    Fungal infection

    Histoplama capsulatum.

    Warm moist environement

    Non-zoonotic

    Found in soil that contains bird or bat feces

    (Wilmes et al., 2022)


    Discussion
    Histoplasmosis Pathogens

    Histoplasma capsulatum is found globally and


    may infect both humans and animals.

    Human/Primates: H. duboisii (africa)

    Equine Histoplasmosis: H. farciminosum


    CLINICAL SYMPTOMS
    weight loss
    fever,
    anorexia,
    respiratory signs
    lameness.

    Gastrointestinal signs
    diarrhea with hematochezia or melena
    are common in dogs.

    (Brömel & Sykes 2005)


    SMALL INTESTINE

    Villi are diffusely blunted and


    fused, and the lamina propria
    is expanded and effaced by

    Pathological and large numbers of


    inflammatory cells (Walden et
    Histopathological al. 2022)

    Changes
    CUTANEOUS LESION

    The small 2–5 µm, oval-to-


    round, single-walled yeasts
    are found in the
    macrophages (Larsuprom et
    al. 2018)
    ~ TREAMENT ~
    Itraconazole (10 mg/kg every 24 hours- Dogs and
    cats)
    Ketoconazole (10–15 mg/kg, every 12 hours, for 4–6
    months- Dog)
    Amphotericin B
    ~ DIAGNOSIS ~
    Antigen testing using a quantitative antigen
    ELISA can be performed on urine, serum, and
    CSF
    H Capsulatum can be cultured from tissue
    specimens, fine-needle aspirates and body
    fluids
    REFERENCES

    Guimarães, A. J., Nosanchuk, J. D., & Zancopé-Oliveira, R. M. 2006. Diagnosis of


    histoplasmosis. Brazilian Journal of Microbiology. 37: 1-13.

    Larsuprom L, Duangkaew L, Kasorndorkbua C, Chen C, Chindamporn A, Worasilchai N. 2018.

    Feline Cutaneous Histoplasmosis : The First Case Report from Thailand. Medical Mycology
    Case Report. 3(18): 28-30

    Sykes JE. 2013. Canine and Feline Infectious Diseases. Amsterdam (NL): Elsevier.

    Walden BP, Radisic R, Warshaw M. 2022. Pathology in Practive. Journal of the American
    Veterinary Medical Association. 259(2): 354-361
    THANKYOU

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