Waktu Konsentrasi Plasma cp terminal cp residual AUC

0.5 19.3 19.4220926510619 0.12209265 9.2175

1 17.57 17.6707585584125 0.10075856 13.072
1.8 15.11 15.1911225516604 0.08112255 27.61
4 9.99 10.0232882910466 0.03328829 15.408
5.8 7.13 13.024
8 4.71 13.86
12 2.22 8.817
18 0.719 2.847
24 0.23
103.8555
Y=0,1494e-0,371+21,347e-0,189x

Obat/Parameter ke T1/2 Vd D
Antibiotik 0.189 3.66666666666667 70267.4849 1500000
 Kurva Distribusi
0.15

0.1 f(x) = 0.149370493325797 exp( − 0.37082807709097 x )

R² = 0.995596759974024
0.05

0
0 0.5 1 1.5 2 2.5 3 3.5 4 4.5
0.5 0.122093
1 0.100759
1.8 0.081123
4 0.033288

Kurva Terminal
AUC Cl F Cp0
5
103.8555 14443.1445614 1 21.347
f(x) = 21.3470669757816 exp( − 0.188645680574564 x )
4 R² = 0.999992906015859
3

0
6 8 10 12 14 16 18 20 22 24 26
574564 x )

22 24 26
t(jam) c (ug/mL) cp Terminal cp residual AUC
0 54.05 9.0009 45.0491 2.1265
0.05 31.01 8.700883500939 22.3091165 1.262
0.1 19.47 8.410867101835 11.0591329 0.827
0.15 13.61 8.130517481024 5.479482519 0.605
0.2 10.59 0.48875
0.25 8.96 0.42475
0.3 8.03 0.387
0.35 7.45 0.36225 0
0.4 7.04 0.34425 0.05
0.45 6.73 0.33 0.1
0.5 6.47 0.3175 0.15
0.55 6.23 0.306
0.6 6.01 0.2955
0.65 5.81 0.2855
0.7 5.61 0.27575
0.75 5.42 0.2665
0.8 5.24 0.2575
0.85 5.06 0.24875
0.9 4.89 0.2405
0.95 4.73 0.2325
1 4.57
AUC Total 9.8835

Y= 45,04e-14,04+9,0009e-0,678x

Obat/Parameter Ke T1/2 Vd D AUC

Anti Nyeri 0.678 1.022123894 7221.5000722 65000 9.8835
 Kurva Distribusi
50
45
40 f(x) = 45.0399013270341 exp( − 14.0439316690225 x )
35 R² = 0.999999926230785
30
25
20
15
45.0491 10
22.309116499061 5
0
11.059132898165 0 0.02 0.04 0.06 0.08 0.1 0.12 0.14 0.16
5.479482518976

Kurva Teminal
5.1
5 f(x) = 9.00094102721739 exp( − 0.677653872325443 x )
R² = 0.999960861765406
4.9
4.8
4.7
4.6
4.5
4.4
4.3
0.84 0.86 0.88 0.9 0.92 0.94 0.96 0.98 1 1.02

CL F Cp0
6576.6175949815 1 9.0009
443 x )

0.98 1 1.02