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Ace Inhibitors Captopril Drug Study Group A
Ace Inhibitors Captopril Drug Study Group A
DRUG STUDY
Allergic to : None
Generic / Brand Dose, Strength Indication/Mechanism Adverse Effects & Nursing Responsibilities Client Teaching
Name & Classification And Formulation Of Action Contraindications
Generic: Ordered: Indication: Adverse Effects: ● Monitor BP closely ● Report to the physician
Captopril 25 mg tid/bid • Hypertension ● CAPTOPRIL following the first dose. without delay the onset of
If satisfactory • Heart Failure mnemonic A sudden exaggerated unexplained fever, unusual
reduction of BP is • Left Ventricular ○ Cough hypotensive response fatigue, sore mouth or throat,
Brand: not achieved within • Dysfunction After ○ Allergy (Rash, may occur within 1–3 h easy bruising, or bleeding.
Capoten 2 wks. Dosage may • Myocardial Urticaria) of first dose, especially ● Consult a physician promptly
be increased to 50 Infarction ○ Potassium in those with high BP or if vomiting or diarrhea
mg tid/bid • Diabetic Elevation on a diuretic and occurs.
Classification: Nephropathy ○ Proteinuria restricted salt intake. ● Report darkening or
Ace Inhibitor Timing: ○ Taste change ● Advise bed rest and BP crumbling of nailbeds.
Same time Mechanism of Action: ○ Oedema monitoring for the first ● Taste impairment occurs in
everyday, Captopril blocks the (Angioedema) 3 h after the initial dose. 5–10% of patients and
recommended 1 conversion of angiotensin I ○ Photosensitivity ● Monitor therapeutic generally reverses in 2–3 mo
hour prior to meal. to angiotensin II and ○ Renal Failure effectiveness. At least 2 even with continued therapy.
prevents the degradation of ○ Indigestion wk of therapy may be ● Use OTC medications only
Duration: vasodilatory ○ Low blood pressure required before full with the approval of the
Onset of action is prostaglandins, thereby therapeutic effects are physician. Inform the surgeon
10-20 minutes, with inhibiting vasoconstriction achieved. or dentist that captopril is
maximal effect
reaching within 1 and promoting systemic ● Lab tests: Establish being taken. Alert diabetic
hour. Apparent half- vasodilation. baseline urinary protein patients that captopril may
life is 2 hours Contraindications: levels before initiation produce hypoglycemia.
of therapy and check at Monitor blood glucose and
Other Forms: ● History of monthly intervals for HbA1c closely during the first
Tablet: angioedema related the first 8 mo of few weeks of therapy.
12.5 mg to ACE treatment treatment and then ● Do not breastfeed while
25 mg ● Hereditary or periodically thereafter. taking this drug.
50 mg idiopathic Perform WBC and
100 mg angioneurotic differential counts
oedema before therapy is begun
● Concomitant use and at approximately 2-
with aliskiren esp in wk intervals for the first
patients with 3 mo of therapy and
diabetes mellitus or then periodically
renal impairment thereafter.
and neprilysin
inhibitor
● Pregnancy
References:
Anon. Captopril. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 21/11/2013.
Anon. Captopril. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/11/2013.
Buckingham R (ed). Captopril. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/11/2013.
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