FACE

VENUCEANE
TM

before aafter 6 months

Photo-ageing
wrinkles
age-spots
dryness

S
Hydrothermal vents
tss

Function:
n::
Anti-ageingg. ave years
in months
Definition:
n::
Biotechnological ferment containingg
multifunctional and stable enzymes.
s.
with effective prevention
Properties:
s::
Prevents the visible signs of photo-ageingg before after 6 months
(spots, wrinkles, dryness...).).
Protects cell structuress
from UV damage. e.
y.
Reinforces skin integrity.
Characteristics:
s::
Thermo-stable, UV-stable, inexhaustiblee
enzymatic activity.
y.
Increasing efficacy with rising temperatures.s..
Origin:
n::
Guaymas Basin (Gulf of California).).
Thermus thermophilus lives in deep-seaa
water (2000 m depth, 75°C temperature,
200 bars pressure).).
e, Leess age-sspots - Less wrinnklees - Less blemishes
Point of interest:t:
An accelerated skin ageing-type process
was used to investigate efficacy on age
stability.
INCI name:
(Check PCPC on-line dictionary for latest INCI name)
Age-proof your skin
Thermus Thermophillus Ferment –
Glycerin

Applications:
Protective day creams, sun protection
products, make-up.

Formulation:
Water soluble. Add in the formula between
room temperature and 80°C
Recommended use level:
3-5%
Patent:
FR 2 821 086 - FR 3 004 351 -
WO 2014/170801 - WO 2002/066668 -
EP 1 392 840 - EP 2 986 305

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Part of Croda International Plc.
 CLAIM SUBSTANTIATION 05-2015

In vivo tests
ANTI-AGEING PREVENTION
Prevention was assessed by analogy with a cream stability test. Under harsh conditions, it is possible to measure the appearance of signs of ageing on the skin after
application of a placebo or an active product for 6 months.
Double-blind clinical study in Mauritius (Dermscan Laboratories) on 2 groups of 25 panellists recently arrived on the island. (Mean age 39). Each group of subjects
applied twice-daily either a placebo or a cream containing 5% Venuceane™.
Moisture maintenance Kinetics Placebo (%) Venuceane™
TEWL was measured with a Tewameter. W4/W0 +7% ns -6% ns
The skin under extreme conditions undergoes significant water loss. W12/W0 +10% ns p=0.081 +5% ns
The product with Venuceane™ stops the dehydration phenomenon. W24/W0 +11% p=0.057 +1% ns

Quality of the Stratum Corneum

Stratum corneum after 24 weeks
With ageing, skin structure loses organization and cohesion.

Venuceane™ promotes epidermal integrity.

Visible parameters of ageing (Visia® system)

% / To Spots Wrinkles Imperfections
Placebo 5µm
Venuceane™ 5µm
quantity surface quantity surface quantity surface
before after 6 months
Venuceane™ -1.1 -1.8 -25.7 -34.4 -0.2 -4.0
Placebo 4.8 9.4 10.3 16.3 6.5 11.1

With ageing, skin exhibits more spots, wrinkles and blemishes.

For the treated panellists, Visia® system detected a decrease for all
the visible parameters of skin ageing. Placebo

before after 6 months

Age of the skin (Visia® system)
Age variation (years) Spots Wrinkles Imperfections Mean
™
Venuceane -0.7 -5.1 -1.4 -2.4
Placebo +3.9 +2.3 +2.3 +2.8
Age saving (years) 4.6 7.4 3.7 5.2 Venuceane™

Panellists treated with placebo underwent accelerated ageing (~ 3 years in 6 months).

The preventive treatment compensates this ageing and allows to save ~5 years in 6 months.

Formulation
Cream with VENUCEANE™ Tested formulation ref.: SED 0503519-I
Part A .................................................................................................................% Part D .................................................................................................................%
Crodamol CAP (Cetearyl Ethylhexanoate, Croda) 5.00 Sodium hydroxide 30% 0.46
Crodafos CES (Cetearyl alcohol & Dicetyl phosphate & ceteth 10 phosphate, Croda) 4.00
Span 60 (Sorbitan Stearate, Croda) 0.50 Part E .................................................................................................................%
Crodamol AB (C12-C15 Alkyl Benzoate, Croda) 2.00 VENUCEANE™ (Sederma) 5.00
Crodamol GTCC (Caprylic/Capric Triglyceride, Croda) 4.00
Part B .................................................................................................................% Protocol:
Potassium sorbate 0.10 Weigh Part A and heat it to 75°C in Bain-Marie. Weigh Part B. Heat Part C until
Deionized water qsp 100 dissolved, and then add it to Part B. Heat Part B+C to 75°C in Bain-Marie. Pour Part A
Part C .................................................................................................................% into Part B+C with staro stirring (s=20%). Extemporaneously, adjust pH with part D.
Glycerin 3.00 Homogenise well. Then add Part E at around 35°C and homogenise well. Check pH
Preservative qs around 6.00 otherwise adjust with Part D. Homogenise well.

Non-warranty : This formulation has been subject to limited stability tests and has been shown to perform well. However formulators adopting this approach should ensure to their own satisfaction long term stability and functionality. It is good practice to conduct safety tests on all final
formulations prior to marketing. Suggested uses should not be taken as an inducement to infringe any existing patents.

Non-warranty: The information in this publication is believed to be accurate and is given in good faith, but no representation or warranty as to its completeness or accuracy
is made. Suggestions for uses or applications are only opinions. Users are responsible for determining the suitability of these products for their own particular purpose. No
representation or warranty, expressed or implied, is made with respect to information or products including, without limitation, warranties of merchantability, fitness for a
29 rue du Chemin Vert particular purpose, non-infringement of any third party patent or other intellectual property rights including, without limit, copyright, trademark and designs. Any trademarks
78612 Le Perray-en-Yvelines cedex France identified herein, unless otherwise noted, are trademarks of the Croda group of companies. ©2018 Sederma 03/18 PCS PO 013 V4 EN
Tel. : +33 (0)1 34 84 10 10 Reproduction of all or part of this document without the express prior written consent of Sederma is strictly prohibited.