Facing The Environment Beautifully Europe - Sederma

Facing the beautifully
environment
By
Prof. Karl LINTNER
KAL’idees S.A.S.
Member of Croda International Plc

© Sederma, June 2014.
Topics of today’s seminar
 On the Face:
• Pollution increases skin sensitivity: Cutaneous barrier
under attack!
• The Proteasome “hazmat” clean-up crew
 On the Body:
• The (infra-)RED menace
• Our stressful life-style: Tired legs?
 On the Hair:
• Pollution induced damages?
Aggressive environment, stressful life style?
The skin is a shield of protection…up to a point
 UV radiation, but also IR
 Chemical and particular pollution of air and water,
 Biological and physical and psychological stress
 Mechanical traumas
 Consequences:
• Disrupted cutaneous barrier and dryness
• Increased Sensitivity
• Irritation & inflammation, redness, insufficient cutaneous blood circulation
• Decreased cell renewal, accumulation of toxins
• Hair damages
• …

Recent science on the topics
 Kolanko E, Czekaj P. Skin and dermal appendages stem cells exposure to tobacco smoke. Przegl Lek.
2013;70(10):858-64.
Stem cells and their microenvironment are potential targets for environmental pollutions, for example tobacco
smoke. Tobacco smoke consists of thousands of substances which can disturb stem cell homeostasis by
evoking, in particular, oxidative stress and hypoxia. Skin is one of the most exposed tissues to tobacco smoke.
 Flohr C1, Mann J. New insights into the epidemiology of childhood atopic dermatitis. Allergy. 2014
Jan;69(1):3-16.
The discovery of the filaggrin skin barrier gene and its importance in AD development and severity has brought the
focus on gene-environment interactions and the identification of environmental factors that impact on skin
barrier function
 Baudouin C et al.. Environmental pollutants and skin cancer. Cell Biol Toxicol. 2002;18(5):341-8.
The "pollutants" that react most specifically with the skin are: ultraviolet radiation, polycyclic aromatic
hydrocarbons (e.g., benzo[a]pyrene), volatile organic compounds (e.g., benzene), heavy metals, and ozone.
Ultraviolet radiation, a "physical" pollutant, has been described as being the factor responsible for most skin
cancers in man
Sensitive Skin? Can we treat/prevent
it? What is it? What are the causes?
 Weakened (thinner) cutaneous barrier
 Irritation and acute or chronic inflammation disorders
(IL6, IL8, TRPV1, Substance P, CGRP)
 Accumulation of various toxins: glycation, free radicals
Hyper
CAUSES sensitivity Unpleasant
. sensations
Fragile
barrier
Redness SIGNS
All types of skin can suffer from sensitivity. Dryness
50% of women and 30% of men claim to be affected.

PACIFEEL™ 3%
PACIFEEL™ is a natural extract of the Mirabilis jalapa plant also known
as the marvel of Peru, native to the tropical areas of South America.
IN VIVO
Instrumental evaluation on sensitive skin

Twice daily application of a cream containing 3% PACIFEEL™
on the face against placebo. Volunteers with sensitive skin and
with a mean age between 35 and 39 years old.
* Results
Alleviates skin discomfort in 21 days
• Pacifying and calming effect* (self-evaluation, n=22)
• Decrease in skin reactivity (self-evaluation after stinging test, n=21)
Fades visible redness

• Redness of reactive skin (colour analysis after stinging test, n=21)
• Redness of sensitive skin* (self-evaluation, n=22)
Improves skin resilience

•Strengthening of the epidermis (confocal microscopy, n=22)
and stratum corneum (evaluation of corneocyte surface area, n=24)
•Hydration (MoistureMeter™, n=24 and VapoMeter™, n= 21)
and skin comfort (self-evaluation, n=30)

alleviates skin discomfort
Pacifying and calming effect In only
Self-evaluation (n=22) - Scoring of discomfort sensation
21 days
Placebo PACIFEEL™ 3%
-22%* -86%, p<0.05
+50%* -13%* -55%* -80%, p<0.01
T0
T21 days
-6%* -15%*
* No significant results
With PACIFEEL™, in only 21 days, the volunteers perceive an overall wellbeing:

itching and stinging sensations are reduced by 80% and 86% respectively.

alleviates skin discomfort
Decrease in skin reactivity (n=21) Stinging
Stinging test at T0 and after 2 months application of 3% PACIFEEL™.
test
Evaluation of the stinging sensation every minute with a 0 to 5 scale.
very marked
marked
10% lactic acid
solution application on
obvious
both sides of the face
, p<0.01
moderate
Significance vs placebo: p<0.01
slight
no stinging
min
With PACIFEEL™, the unpleasant sensation due to cutaneous exposure to irritants is approximately reduced by 30%.

IN VIVO

* Results
• Decreasing in skin reactivity (self-evaluation after stinging test, n=21)



fades visible redness
T0
PACIFEEL™ 3% T2 months Placebo

fades visible redness
Redness evaluation after stinging test (n=21) Self-evaluation (n=22) - Scoring of redness
Photos taken with digital camera
PACIFEEL™ 3% In only
PACIFEEL™ 3% 21 days
Placebo +20%
ns
T0 T2 months
p<0.07
Red component analysis with ColorSkin software
Redness PACIFEEL™ 3% Placebo
Variation vs T0 (%) -3.7%
T0 T21 days
Significance vs T0 p<0.01 ns
Maximum With PACIFEEL™, the volunteers perceive a significant
Responders 71% reduction in facial redness (-54%). Based on image
Significance vs placebo p<0.05 analysis, the redness of reactive skin decreases up to 27%.

IN VIVO

* Results
• Decreasing in skin reactivity (self-evaluation after stinging test, n=21)



improves skin resilience
Before After
PACIFEEL™ helps to strengthen the epidermis and stratum corneum
in order to prevent reactions to environmental factors.
Reinforcement of the stratum corneum (n=24)

Corneocyte surface area based on analysis after staining of adhesive tapes.
T0 , p<0.01 T1 month
PACIFEEL™ µm2
3% 940 960 980 1000
T0 T1 month
Placebo µm2
940 960 980 1000
+4 µm2, ns
Strengthening of the epidermis (n=22)

Epidermal thickness by confocal laser microscopy.
After 2 months PACIFEEL™ 3% Placebo

Variation vs T0 (%) (+11.5%) -1.3 µm (-2.1%) PACIFEEL™
Significance vs T0 p=0.07 ns vs placebo: p<0.05
Responders 68%

IN VITRO
A pacified communication Between the epidermis

and nerve endings
• Reduction in epidermal hypersensitivity
=> by inhibition of TRPV1 sensory receptor: -25%, p<0.05
• Down-regulation of discomfort messengers
 Nerve Growth Factor (NGF): -49%, p<0.01
A reinforced protection Between the epidermis

and the environment
•Restoration of the barrier function
=> by stimulation of TRPV4 sensory receptor: +16%, p<0.01
 Cornified cell envelope – Transglutaminase: +58%, p<0.01
 Cell cohesion (Tight junction) – Occludin: +107%, p<0.01
 Intercellular cement – Ceramides: +45%, p<0.02
•Prevention of dryness
Water reservoir – Hyaluronic acid: +164%, p<0.01
Natural Moisturising Factor – Filaggrin: +44%, p<0.01

PACIFEEL™ targets the causes and signs (sensations
and visible signs) of sensitive skin by considering the
epidermis as both a sensory tissue and a physical barrier.
PACIFEEL™:
•Alleviates cutaneous discomfort thanks to a pacified
communication between the epidermis and nerve
endings.
•Fades redness of sensitive and reactive skin.
•Improves skin resilience against aggressions by restoring
the fragile barrier function between the epidermis and the
environment.
PACIFEEL™ wraps the skin in a comfortable and

protective cocoon. With PACIFEEL™, the skin is pacified
and feels beautiful.
Recommended use at 3%

The Proteasome “hazmat” clean-up crew
 The skin is exposed to various noxious agents like UVAB,
pollution, stress, smoke, junk food that contribute to the
alteration of the cutaneous barrier and premature ageing.
 In the cell, it is possible to visualise the cellular debris
generated by the molecular damage (oxidised or glycated
proteins, protein carbonyls, lipoperoxides, etc). Visualisation of cellular debris in a
senescent keratinocyte culture…
 The accumulation of these toxins in the keratinocytes impairs

cell viability and:
• generates micro inflammations responsible for cutaneous
nerve hyperexcitability and for accelerated ageing
• reduces natural skin glow.
… compared to a young
keratinocyte culture.

IN VIVO
ANTI-AGEING DEFENCE
• Anti-toxin - IMAGES
Skin luminance L* after 2 months
Variation vs placebo +9.2%, p<0.01
BEFORE AFTER 2 MONTHS
RESISTEM™ reduces toxins that darken the skin to reveal its luminosity.
CELL DETOXIFICATION
• Maintenance of proteasome activity
The proteasome is a proteic complex

that degrades damaged proteins.
Test on H2O2 stressed human fibroblasts and 2 applications of 2% RESISTEM™.

Dosage of the activity by measuring the fluorescence of a cleaved peptidic substrate.
On H2O2 stressed human fibroblasts

Control + H2O2 -70%; p<0.01 / control
H2O2 + 2% RESISTEM™ +57%; p<0.01 / control + H2O2
RESISTEM™ stimulates the elimination of damaged proteins.

IN VITRO
RESISTANCE TO OXIDATIVE STRESS

• Maintenance of the mitochondrial potential
The mitochondrial potential is a marker of cell senescence.
Its decrease marks the beginning of apoptosis (cell death).
Test on H2O2 stressed human fibroblasts and application of
2% RESISTEM™.
On H2O2 stressed human fibroblasts

Control + H2O2 -32%; p<0.01 / control
H2O2 + 2% RESISTEM™ +40%; p<0.01 / control+H2O2
RESISTEM™ helps delay apoptosis and prolong cell lifespan.

RESISTEM™ is a plant extract obtained by stem cells
culture from Globularia cordifolia.
RESISTEM™ is the anti-ageing “bodyguard”.
RESISTEM™ is able to induce an anti-ageing protection,

similar to the phenomenon of hormetic response that
mobilises endogenous cutaneous actors:
1.Toxin elimination (proteasome activity)
2.Cell lifespan extension (sirtuin-1)
3.Tissue regeneration (skin stem cells)
RESISTEM™ has shown its abilities to protect the skin

against pro-ageing agents by stimulating cell
detoxification and regeneration reactions to provide anti-
ageing beauty benefits to consumers.

The (infra-)RED menace
Infrared radiation (IR) represents

more than 50% of solar radiation.
UV-B
UV-A
IR-B
IR-C
IR-A
epidermis
dermis
hypodermis

It’s been known for ages that heat
has the power to modify materials…
Protein
denaturation
Sugar
caramelisation
HEAT

The toasted skin syndrome
Or laptop thigh syndrome
a skin condition caused by long-term exposure
to heat. Prolonged thermal radiation exposure to the skin
can lead to the development of reticulated erythema,
hyperpigmentation, scaling and telangiectasias due to
degradation of connective tissue and alteration of elastic
fibers.
With heated car seats as well

Schroeder, Calles C, Krutmann J.Prevention of infrared-A radiation mediated detrimental effects in
human skin. Skin Therapy Lett. 2009 Jun;14(5):4-5.
 Within the solar spectrum, damage results also from near infrared radiation.
 Infrared radiation (IR) alters the collagen equilibrium of the EMC

• by leading to an increased expression of matrixmetalloproteinase-1 and
• by decreasing the de novo synthesis of the collagen itself.
 Infrared-A (IRA) radiation exposure, therefore, induces similar biological effects to UV,
but the underlying mechanisms are substantially different.
Now identified as a major contributor to photo-damage, IR requires specific

strategies in order to achieve a complete and complementary protection to UV.

Infrared radiation vs. Ultraviolet radiation:
Generates a heat increase which catalyses many ageing processes
Induces ROS production in a different way by targeting the mitochondria
Penetrates deeper into the skin for more extensive damage
INFLAMMATION
Heat increase Water loss DEHYDRATION

ROS production
WRINKLES

™
The umbrella against radiation
INFRARED AND SKIN AGEING
By targeting the mitochondria, IR radiation induces an increased
amount of ROS whereas VENUCEANE™ reduces it by 28%.
Human keratinocytes irradiated with IR – ROS production (UFA/104 cell.)

Heat increase
ROS production
+29%
p<0.01
■ Irradiated
™ vs non-irradiated control
Water loss
■ Venuceane™ eq 1.5%
INFLAMMATION WRINKLES vs IR-irradiated control
-28%
DEHYDRATION p<0.01

™
INFRARED AND SKIN AGEING
PROTECTION FROM INFLAMMATION
Pro-inflammatory mediators production vs IR-irradiated control:
PGE2: -54%, p<0.01; IL-6: -53%, p<0.01; IL-8: -61%, p<0.01
Heat increase HYDRATION IMPROVEMENT

via the protection of the mitochondrial integrity:
ROS production
ATP synthesis: +123%, p<0.01
Mitochondrial water: +123%, p<0.01
™
DERMAL ARCHITECTURE MAINTENANCE
Protein synthesis vs IR-irradiated control:
Collagen integrity: MMP-1: -38%, p<0.01; HSP-47: +44%
=> Collagen I: +70%, p<0.01
Water loss
Elastin architecture: Fibrillin-I: +28%, p<0.01
INFLAMMATION WRINKLES
DEHYDRATION

™
HYDRATION IMPROVEMENT
By protecting mitochondrial integrity from IR-induced ROS production,
Venuceane™ preserves and stimulates the mitochondrial metabolism.
Mitochondrial respiratory chain Venuceane™ eq 1.5%

On human keratinocytes
ATP synthesis
+123%
p<0.01
+ Venuceane™ H2O H2O Mitochondrial water content

ATP
Energy and water production +123%
p<0.01
With Venuceane™, energy production and mitochondrial water content increase

and contribute to hydration improvement.

™
Migration front
Ceramide synthesis in
keratino-cytes
Free fatty acids
Lanosterol
Cholesterol
Ceramide type 2
Glycoceramides
Galactocerebrosides
Un-identified bands
Unidentified bands
Control Venuceane
™
Cyanoacrylate strip of skin treated Cyanoacrylate strip of skin treated

with VENUCEANE for 2 months with control for 2 months
SEM micrographs of corneocytes ; magnification 1050

™
A COMPLETE PROTECTION
Venuceane™ seems by far the most complete active ingredient to effectively fight against photo-ageing.
Previous tests New tests

UV PROTECTION IR PROTECTION
Protection of natural enzymatic detoxifiers (in vivo) Detoxifying activities proportional to the heat increase
Protection against DNA oxidation Protection from IR-induced ROS production
Protection of the cell membrane Under UVA radiation and inflammation Under IR radiation
HYDRATION
Reinforcement of the cutaneous barrier Increase in mitochondrial water content via the protection
Reduction of water loss after induced lesion (in vivo) of the mitochondrial integrity
ANTI-AGEING
Visible reduction in signs of ageing (in vivo study carried Maintenance of the dermal architecture
out in Mauritius over 6 months) Under sun light to delay wrinkle formation Under IR radiation

Our stressful life-style: Tired legs?
Heat, Stilettoes, Sitting, Shopping, Overweight, Travelling…
There are numerous factors that make legs feel tired and uncomfortable.

Our stressful life-style: Tired legs?
What are the physiological events associated with leg discomfort:
Slow blood flow
Adipocyte development
Tissue compression
Inflammation
Degradation of the ECM and

the vessel walls
Leak of fluids from vessels to ECM

Weakening of the tissues

™
In vivo (Parameters measured and effects

obtained)
 Thickness of the adipose tissue
 Water retention
 Visco-elastic properties
 Quantity of water retained in the
tissue
Improved circulation
 Circulation dynamism
Leaner legs
 Leg circumference and volume
More beautiful and comfortable legs

 Clinical evaluation under control of a
Phlebologist
24 female volunteers, mean age 40
™ Cream @ 3% Legance™ or vehicle
THICKNESS OF THE ADIPOSE TISSUE AT THE ANKLES
After 2 month’s use, Legance ™ significantly reduces the thickness of the adipose tissue at the ankles
by 5.8% .
Ultrasonic echography 10 MHz
Thickness LEGANCE™ Vehicle

T 1 month T 2 months T 1 month T 2 months
Variation vs T0 -0.42 mm -0.77 mm 0.05 mm -0.06 mm
Variation vs. T0 (%) -3.2% -5.8% 0.4% -0.5%
Significance p<0.01 p<0.01 dns dns
Maximum  -12%  -24%
Responders 80% 92%
Significance vs placebo p<0.05 p<0.01

™
CIRCULATION DYNAMISM
After 2 month’s use, Legance™ significantly improves the circulation dynamism of the leg.
Blood flow measurement by Laser Doppler Imager after a movement

of the leg: response capacity to stimuli.
Basal 3 min
Legance™
* p<0.05/vehicle
** p<0.01/vehicle
Vehicle
™
CIRCUMFERENCE AND VOLUME OF THE LEG
mm After 2 month’s use, Legance™
significantly helps to refine the legs.
Centrimetric measurements positioned with

a laser
(1) p<0.01/T0 and/vehicle

(2) p<0.05/T0
(3) p<0.05/vehicle
1 month 2 months
Volume 3% LEGANCE™ Vehicle
T 1 month T 2 months T 1 month T 2 months
Variation vs T0 -92 ml -229 ml -44 ml -78 ml
Variation vs. T0 (%) -1.1% -2.6% -0.5% -0.9%
Significance p<0.01 p<0.01 dns dns
Maximum  -3.8%  -7.6%
% Responders 63% 79%
Significance vs Vehicle p<0.01 p<0.01

™
CLINICAL EVALUATION UNDER CONTROL OF A PHLEBOLOGIST
Evaluation by a Phlebologist based on the intensity of varicose veins and presence of blue varicose veins.
Scoring of the comfort (pain and heaviness in the legs).
* p<0.06/T0
** p<0.01/T0
63% of the volunteers felt their legs less painful by 39%.

78% of the volunteers felt a noticeable leg relaxing effect by 40%.

™
In vitro EVALUATION of mechanisms: PROTECTION and REPAIR
PROTECTION AND REPAIR OF THE REDUCTION IN THE ADIPOSE PROTECTION OF THE VASCULAR
EXTRACELLULAR MATRIX TISSUE ENVIRONMENT
Protection of the dermis against the Inhibition of adipocyte maturation: Reduction in the synthesis of pro-
effects of proteases  -91% (G3PDH activity) inflammatory mediators:
Visualisation by confocal microscopy using Reduction in adipocyte storage:  PGE2: -89%
the Vivascope® on human skin explants  -29% (triglycerides)  IL-6: -97%
Protection of the extracellular Reduction in adipocyte Modulation of the oxidising stress
matrix: inflammation: caused by reactive oxygen species
Production of MMP1: -51%  Adiponectin: +95% and free iron:
Production of cathepsin S: -34%  IL-6: -73%  Inhibition of the ROS: -55%
Repair of the extracellular matrix:  Synthesis of ferritin: +68%
Synthesis of fibromodulin: +268% Reduction of the activity of
Synthesis of dermatopontin: +137% macrophages stressed LPS:
 TNF-α: -40%
 IL-6: -92%
 VEGF: -41%

™
Every woman should

have it in her handbag...
Here is the solution for
terribly sexy and relaxed legs.
Legance™ is designed to provide a global

anti-ageing benefit to the legs: Legance™
has proved its efficiency to improve the
appearance and comfort of the legs by
reducing water content and refining the
adipose tissue.
Legance™ is based on an extract of Zingiber

zerumbet obtained by supercritical CO2.
It is recommended to use Legance™ at 3%.

Hair: Pollution induced damages?
In everyday life, hair is exposed to aggression, to free radicals, to pollutant
particles which can coat the hair surface to reduce the shine, to roughen
the surface, but also to impregnate hair with bad odour
Rough hair surface.

Potential anchoring sites for
pollutant particles
Smooth hair surface. Offer less

potential anchoring sites.

Pollutant particles with low refractive index (gas particles, etc…)
 loss of shine
Rough hair surface

Pollutant particles with smelling potential (Cigarette smoke / fried food )
 Bad odours
Cigarette smoke
A rough hair surface is likely to catch
pollutant particles as it has much more
anchoring sites available.
Food smell

ANTI-POLLUTION FOR HAIR
Virgin hair Permed hair
Placebo FRUITBIO
Shampoo 1 minute Shampoo 0.5% Fruitbio 1 minute
Rinse Rinse
Conditioner 1 minute Conditioner 1% Fruitbio 1 minute
Rinse Rinse
Mask 1 minute Mask 1% Fruitbio 1 minute
Rinse Rinse
Drying Drying
Potential Smooth surface

anchoring sites

Evaluation of the smoothing effect
Scanning electron microscopy acquisition coupled
with image analysis
Hair treated with placebo

Evaluation of the smoothing effect
Scanning electron microscopy acquisition coupled
with image analysis
Hair treated with
FRUITBIO
Smoother surface, less

anchoring sites for particles.

Evaluation of the condition of the hair surface (damage)
PLACEBO TREATED FRUITBIO TREATED
OCCUPIED (DAMAGED) OCCUPIED (DAMAGED)

SURFACE : SURFACE :
21 % 12 %
ROUGHNESS : ROUGHNESS :
1436 820

Particle adhesion study
Ex vivo study of the adhesion of polluting particles on normal hair and permed
hair.
 Treatment of hair strands with a shampoo containing 0.5% of

FRUITBIO and a hair mask containing 2% of FRUITBIO against
placebo.
 Hair is then exposed to air loaded with fluorescent coal particles.
 Measurement of the adhesion of particles by image analysis.

Ex vivo study of the adhesion of polluting particles on normal hair and permed hair.

hair.

Ex vivo study of the adhesion of polluting particles on normal hair and permed hair.

hair.

Hair protected with
Pollution particles stick strongly at HELIOGENOL
normal, UV damaged and permed
hair.
It is possible to decrease
significantly the adhesion of Hair damaged by
UV radiation
particles thanks to the smoothing
effect of the FRUITBIO, an alliance
of green tea extract combined with
lactic, citric, malic acids.

We have to live with stress and aggression…
But we can fight them!
And we should
The skin is our first line of defence: also think
about
changing our
 We need an efficient skin barrier: PACIFEEL
way of life to
limit pollution.
 We need UV and IR protection: VENUCEANE For us it starts
with more
 We need DETOX action: RESISTEM and LEGANCE sustainable
production
modes
 We need PREVENTIVE CARE: VENUCEANE (Supercritical
CO2, PCC,…)
 We also need beautiful hair: FRUITBIO

Facing the beautifully
environment
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product related
information?
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Facing the beautifully

Member of Croda International Plc

Member of Croda International Plc

Member of Croda International Plc

Instrumental evaluation on sensitive skin

Fades visible redness

Improves skin resilience

Member of Croda International Plc

-22%* -86%, p<0.05

+50%* -13%* -55%* -80%, p<0.01

With PACIFEEL™, in only 21 days, the volunteers perceive an overall wellbeing:

Member of Croda International Plc

Member of Croda International Plc

Instrumental evaluation on sensitive skin

Fades visible redness

Improves skin resilience

Member of Croda International Plc

PACIFEEL™ 3% T2 months Placebo

Member of Croda International Plc

Member of Croda International Plc

Instrumental evaluation on sensitive skin

Fades visible redness

Improves skin resilience

Member of Croda International Plc

Reinforcement of the stratum corneum (n=24)

Strengthening of the epidermis (n=22)

After 2 months PACIFEEL™ 3% Placebo

Member of Croda International Plc

A pacified communication Between the epidermis

A reinforced protection Between the epidermis

Member of Croda International Plc

PACIFEEL™ wraps the skin in a comfortable and

Member of Croda International Plc

 The accumulation of these toxins in the keratinocytes impairs

Member of Croda International Plc

BEFORE AFTER 2 MONTHS

The proteasome is a proteic complex

Test on H2O2 stressed human fibroblasts and 2 applications of 2% RESISTEM™.

On H2O2 stressed human fibroblasts

RESISTEM™ stimulates the elimination of damaged proteins.

Member of Croda International Plc

RESISTANCE TO OXIDATIVE STRESS

On H2O2 stressed human fibroblasts

RESISTEM™ helps delay apoptosis and prolong cell lifespan.

RESISTEM™ is the anti-ageing “bodyguard”.

RESISTEM™ is able to induce an anti-ageing protection,

RESISTEM™ has shown its abilities to protect the skin

Member of Croda International Plc

Infrared radiation (IR) represents

Member of Croda International Plc

Member of Croda International Plc

With heated car seats as well

Member of Croda International Plc

 Infrared radiation (IR) alters the collagen equilibrium of the EMC

Now identified as a major contributor to photo-damage, IR requires specific

Member of Croda International Plc

Heat increase Water loss DEHYDRATION

Member of Croda International Plc

Human keratinocytes irradiated with IR – ROS production (UFA/104 cell.)

Member of Croda International Plc

Heat increase HYDRATION IMPROVEMENT

Elastin architecture: Fibrillin-I: +28%, p<0.01

Member of Croda International Plc