Hypert ension

i s M . M e ñ ez
John Franc
 What is hypertension?
High blood pressure, also called hypertension, is blood pressure that is higher than normal. Your
blood pressure changes throughout the day based on your activities. Having blood pressure
measures consistently above normal may result in a diagnosis of high blood pressure (or
hypertension).

Being overweight or obese.

Lack of physical activity.
Too much salt in the diet.
Too much alcohol
consumption
 01 NOSEBLEEDS

02 VISION CHANGES

SYMPTOMS 03 EARLY MORNING HEADACHE

04 BUZZING IN THE EARS

05 IRREGULAR HEART RHYTHMS

BSPHARMA32
DISPENSING 2
 PREVENTION

High blood pressure can often be prevented or

reduced by eating healthily, maintaining a
healthy weight, taking regular exercise, drinking
alcohol in moderation and not smoking.
 ANGIOTENSIN CONVERTING ENZYME
INHIBITORS
(ACE INHIBITORS)

DRUG INTERACTION

ENALAPRIL Antihypertensive agents 

BENAZEPRIL Can cause an increased effect of medications, especially with diuretics.
CAPTOPRIL Potassium-increasing medications
ENALAPRIL Cause an increased risk of hyperkalemia due to the suppression of aldosterone. 
FOSINOPRIL
Lithium 
LISINOPRIL 
Increases the risk of lithium toxicity. 
MOEXIPRIL
PERINDOPRIL Allopurinol 
QUINAPRIL  Increases hypersensitivity to the medication 
RAMIPRIL NSAIDS 
TRANDOLAPRIL Reduce the antihypertensive effects of medication.
 ANGIOTENSIN RECEPTOR BLOCKERS
(ARB'S)

DRUG INTERACTION

LOSARTAN
OLMESARTAN
VALSARTAN Combining ARBs with potassium supplements, salt substitutes (often
TELMISARTAN contain potassium), or other drugs that increase potassium (for example,
IRBESARTAN spironolactone), may result in excessive blood potassium levels
AZILSARTAN (hyperkalemia) because ARBs also increase potassium levels.
CANDESARTAN
EPROSARTAN
 CALCIUM CHANNEL BLOCKING AGENTS

DRUG INTERACTION

AMLODIPINE Avoid grapefruit products while taking certain calcium channel blockers.
DILTIAZEM Grapefruit juice interacts with the drug and can affect heart rate and blood
VERAPAMIL pressure. This can cause symptoms such as headaches and dizziness.
NIFEDIPINE
FELODIPINE Calcium channel blockers should always be taken with a meal or a glass of
milk to protect the stomach.
NICARDIPINE
 THIAZIDE DIURETICS

DRUG INTERACTION

BENDROFLUMETHIAZIDE
Drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs) such
CHLOROTHIAZIDE
as ibuprofen (Motrin), naproxen (Naprosyn), and nabumetone
CHLORTHALIDONE
(Relafen) can reduce the effectiveness of thiazide diuretics in lowering
HYDROCHLOROTHIAZID
blood pressure because they may reduce the ability of the kidneys to
INDAPAMIDE
make urine, particularly in patients who have reduced kidney function.
METOLAZONE
 LOOP DIURETICS

DRUG INTERACTION

medicines to treat, or which have the side effect of, an irregular

heartbeat, including amiodarone, digoxin, disopyramide,
flecainide, or sotalol
medicines that can change the level of potassium in your blood,
ETHACRYNIC ACID
such as potassium supplements, steroids, or other diuretics
BUMETANIDE
painkillers known as non-steroidal anti-inflammatory drugs
FUROSEMIDE
(NSAIDs), including diclofenac, ibuprofen, or naproxen
TORSEMIDE
medicines that treat high blood pressure, or those that have a side
effect of low blood pressure
 POTASSIUM-SPARING DIURETICS

DRUG INTERACTION

medicines that can change the level of potassium in your blood,

such as potassium supplements, steroids, or other diuretics
AMILORIDE
painkillers known as non-steroidal anti-inflammatory drugs
EPLERENONE
(NSAIDs), including diclofenac, ibuprofen, or naproxen
SPIRONOLACTONE
medicines that treat high blood pressure, or those that have a side
TRIAMTERENE
effect of low blood pressure
 CARBONIC ANHYDRASE INHIBITORS

DRUG INTERACTION

Acetazolamide can decrease the excretion of dextroamphetamine,

anticholinergics, mecamylamine, ephedrine, mexiletine, or quinidine
ACETAZOLAMIDE because carbonic anhydrase inhibitors increase the alkalinity of the
urine, thereby increasing the amount of nonionized drug available for
renal tubular reabsorption.
Thank you for
listening!