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Comparative Study Anticancer Res. May-Jun 1999;19(3B):2173-80.

Title & authors

Cancer risk associated with simian virus 40
contaminated polio vaccine Abstract

S G Fisher  1 , L Weber, M Carbone Similar articles

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Cited by
PMID: 10472327
Publication types
Abstract
MeSH terms
Background: The presence of SV40 in monkey cell cultures used in the preparation of the polio
vaccine from 1955 through 1961 is well documented. Investigations have consistently demonstrated
Substances
the oncogenic behavior of SV40 in animal models. Early epidemiologic studies were inadequate in
demonstrating an increase in cancer incidence associated with contaminated vaccine. Recently,
Related information
investigators have provided persuasive evidence that SV40 is present in human ependymomas,
choroid plexus tumors, bone tumors, and mesotheliomas, however, the etiologic role of the virus in
Grant support
tumorigenesis has not been established.

Materials and methods: Using data from SEER, we analyzed the incidence of brain tumors, bone LinkOut - more
tumors, and mesotheliomas from 1973-1993 and the possible relationship of these tumors with the resources
administration of the SV40 contaminated vaccine.

Results: Our analysis indicates increased rates of ependymomas (37%), osteogenic sarcomas (26%),
other bone tumors (34%) and mesothelioma (90%) among those in the exposed as compared to the
unexposed birth cohort.
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Conclusions: These data suggest that there may be an increased incidence of certain cancers among
the 98 million persons exposed to contaminated polio vaccine in the U.S.; further investigations are
clearly justified.

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Publication types
Comparative Study
Research Support, U.S. Gov't, P.H.S.

MeSH terms
Age Factors
Bone Neoplasms / epidemiology*
Bone Neoplasms / etiology
Brain Neoplasms / epidemiology*
Brain Neoplasms / etiology
Choroid Plexus Neoplasms / epidemiology
Cohort Studies
Databases, Factual
Drug Contamination*
Ependymoma / epidemiology
Humans
Incidence
Mesothelioma / epidemiology*
Mesothelioma / etiology
National Institutes of Health (U.S.)
Osteosarcoma / epidemiology
Poliovirus Vaccine, Inactivated / adverse effects*
Risk Assessment
Risk Factors
Simian virus 40 / isolation & purification
Simian virus 40 / pathogenicity*
United States / epidemiology

Substances
Poliovirus Vaccine, Inactivated

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