Professional Documents
Culture Documents
Idl 50375
Idl 50375
to improving
research costing in
low- and middle-
income countries
2012
Contents
Five keys
KEY 1 Defining and categorizing 8
and Evaluation
direct and indirect costs
to improving
Framework for Capacity
direct and indirect costs
research costing in
Strengthening in
Case studies on developing 14
a full-cost model
Health
income countries
Research research grants
ESSENCE on Health Research1 is an initiative review the practices of funders and recipients
between funding agencies to improve the related to the definition and funding of direct
coordination and harmonization of research- and indirect costs. The learnings from that
capacity investments. Recognizing the review are contained in this document.
particular complexities involved in health-
related research, ESSENCE aims to improve It is hoped that this document will provide
the impact of investments made in institutions ESSENCE members, and the research
and their employees, and to provide enabling institutions they support, with information
mechanisms that address the national needs that will help all parties to (i) better
and priorities of health research in the funded understand the challenges and requirements
countries. of research costing, (ii) develop appropriate
mechanisms for costing future research
Although ESSENCE is health-focused, this accurately and sustainably, and (iii) that it
document has wider reach and can be used will act as a channel for further engagement
across all research fields. between funders and institutions.
Introduction
Research institutions in low- and middle- and not being able to sustain their research
income countries (LMICs) are critical to the environments.2
pursuit of country-led research agendas. It is
essential that these institutions both develop In most research projects the direct costs
and maintain their research environments are seldom at issue. Indirect costs present
to sustain high-quality research. Access far more difficulties in terms of how they are
to adequate funding is clearly essential. defined, whether they qualify for funding and
While access to funds is a huge challenge how they are calculated. Some of the reasons
for research institutions all over the world, behind this are that
it is even more critical in LMICs where Indirect costs are often not calculated
governments are often not in a position accurately or consistently by research
to prioritize and fund research. Certainly, institutions
much of the financing for health research Funders have diverse policies and practices
that takes place in LMICs is derived from related to reimbursement of indirect costs
foreign sources.1 There are a multiplicity of The coordination of external research
sources of funding within sustained research grants is underdeveloped within research
environments such as governments, councils, institutions, which creates multiple
funders and philinathropists. In the current inefficiencies and may contribute to
global context, in which competition for a avoidable losses
finite pool of research funding is constantly Dialogue between funders and institutions
increasing, improving access to funding is is inadequate
ever more relevant for LMICs and for the
donors that wish to support them. From a survey carried out by ESSENCE
members, which was responded to mainly by
It is widely accepted that for most research organisations based in sub-Saharan African
projects, full costs include both direct and countries, rates set by research institutions
indirect costs. It is thus clear that the ability in LMICs range from 8 to 35%, and average
of institutions to accurately determine and out at 15%. Irrespective of how these rates
recover costs, and then to strategically are determined, they are far lower than those
reinvest these recovered costs, depends set by institutions in other parts of the world.
greatly on the availability of supportive For example, in the US, the national average
institutional structures with the relevant is 51% of salaries and wages, in Sweden it
strategic and operational competencies. It is is 50% and above of the direct costs; and
also well known that health-related research in the UK, the rate is 60% of salaries and
brings with it a high level of complexity wages. It is interesting to note, however,
in terms of line items that require funding that among funders that work in LMICs and
(from ethics committees to using, building or which participated in the ESSENCE survey, the
equipping of clinic facilities, from patient care indirect-cost rates that they routinely cover
to statistical-analysis software, etc). varied between just 8 and 13%.
initiated a study to examine the research- of a repository of case studies and learning
costing practices of both funders and funding experiences – please refer to the last page
recipients, and to open a channel for these of this document if you have feedback, case
organizations to engage with one another studies or other information to share on the
while focusing particularly on the issue of issues
indirect costs. discussed here.
The study led to the publication of two 1 See COHRED Health Research Web. Financing and Partnership (http://www.
documents that are linked but have different healthresearchweb.org/en/finance_for_research_for_health).
purposes. The first is Research Costing 2 It is notable that, in countries where institutions have implemented full-costing
Practices: Bridging the Gap in the Funding of models (or are in the process of doing so), an additional driver has always been
present. In Europe, for example, the European Commission, through the FP7
Health Research in Low- and Middle-Income programme, was one of the key drivers motivating institutions across Europe
Countries, which provides further background to move towards full-costing. (See European Commission Directorate-General
information about the ESSENCE study, for Research (2009) Diversified Funding Streams for University-Based Research:
Impact of External Project-Based Research Funding on Financial Management
and contains additional case studies and in Universities. Luxembourg: Office for Official Publications of the European
examples. It is available online from Communities. http://ec.europa.eu/invest-in-research/pdf/download_en/
http://www.who.int/tdr/partnerships/ external_funding_final_report.pdf; and T Estermann and E Bennetot Pruvot (2011)
Financially Sustainable Universities II – European Universities Diversifying Income
initiatives/essence. The second document is Streams. Brussels: European University Association) Available at http://www.eua.
the one you are reading now. It is designed as be/Pubs/Financially_Sustainable_Universities_II.pdf).
a concise and practical resource for research 3 Copies of the survey questionnaires are available at http://www.magnetmail.
institutions, research managers, and donor net/forms/display_form.cfm?uid=AGHF&fid=28427&rtype=nonmm and http://
www.surveymonkey.com/s.aspx?sm=2RUAIqAkTNIR9_2blipblsJw_3d_3d. . A total
organizations. We hope you find the document of 15 funding organizations responded, and 128 responses were received from
useful and look forward to receiving your individuals based at 96 institutions in 47 countries. Of these, 54% of respondents
feedback on the issues discussed. In support were based at universities 35% at research institutes. The remaining 11% of
responses came from government departments, national ethics committees and
of dialogue and shared learning, a forum for professional associations.
shared learning is being created in the form
6 FIVE KEYS TO IMPROVING RESEARCH COSTING IN LOW- AND MIDDLE-INCOME COUNTRIES
This guide addresses the issue of indirect costs, as distinct from direct costs, in particular
and seeks to assist the reader in defining, understanding and preparing these costs for the
maximum benefit of the institution and project. It should however be borne in mind that the
financial management of and the budgeting for research projects are dealt with differently by
different funders and even within the range of projects and programmes supported by funders.
Terms such as variable and fixed costs, capital expenses and capital investment are further
areas for attention by the research programme and project planners.
The starting point is for organizations to identify and reach consensus on the broad
categorization of direct and indirect costs. On the one hand, this will enable research
institutions to cost their research activities more accurately, while on the other hand it will
assist funders to harmonize their practices and efforts.
Funder
South Africa is so far the only country in In addition, it has been agreed that HESA
Africa that has used legislation to encourage (Higher Education South Africa) should
research institutions to move towards full coordinate the efforts of research institutions
costing. The Intellectual Property Rights from to comply with the Act. HESA appointed a
Publicly Financed Research and Development task team that, through consulting all the
Act, (No. 51 of 2008) came into effect in higher-education institutions in the country,
August 2010. Its primary goal is to ensure plans to propose two or three costing models
that intellectual property generated through to NIPMO early in 2012. NIPMO will consider
the use of public funds is used to benefit the these models and, through a process of input
people of South Africa. The Act applies only to and amendment, put forward a national model
projects and research contracts that are fully for calculating full costs. The University of the
or partially state funded (in other words, the Free State developed one of the models that
Act does not apply when funders cover the full was proposed to NIPMO, and Stellenbosch
cost of the research). In terms of the Act, the University has implemented a full-cost model.
National Intellectual Property Management Lessons learned at these two universities are
Office (NIPMO) was established, and has are presented in the case studies that follow.
called on all publicly funded higher education
institutions to develop their own full-costing
policies as a step towards developing a
nationally accepted full-costing model.
FIVE KEYS TO IMPROVING RESEARCH COSTING IN LOW- AND MIDDLE-INCOME COUNTRIES 15
The university proposed the following process for Information about these overheads can be obtained
calculating an indirect-cost rate. The general principles from the university’s information-management
and assumptions of the model include: system;
The indirect-cost rate is based on historic cost
The audited consolidated income statement of the recovery data collated over a three-year period, that
university forms the consolidated comprehensive is, the rate is adjusted annually based on the average
income statement; costs of the previous three years.
Overheads are assumed to be the personnel costs
and the operating expenses of certain service The table below shows the basic steps that they
departments; propose should be involved in calculating an indirect-
cost rate.
that all grant applications be signed off and good understanding of their own finance
submitted through the designated authority structures and costs, as well as a measure
of the institution. of persistence in the negotiation process
The grants management function or office and the ability to prove to funders that their
should review and approve all project rates were reasonable.
proposals before submission to a funder.
This ensures more accurate budgets and
stronger institutional commitment to the Recovering and distributing indirect
project; it also facilitates the maintenance costs recovered
of institutional database(s) that, in turn,
support the monitoring of projects and their Transparency regarding the internal
budgets. disbursement of recovered costs is one of
the most important parts of promoting the
benefits of research costing and gaining
Setting up guidelines, policies, and support for the recovery of indirect costs.
procedures for grants management To facilitate this, institutions require
mechanisms to calculate recovered costs
Institutional policies and guidelines must plus a clear policy on how recovered funds
be written, documented and approved at will be distributed. Once researchers
institutional level. They should be updated see how they, and their direct research
as institutions grow and the external environments, stand to benefit from
environment produces changes. recovered indirect costs, they quickly
Policies should be reviewed to ensure develop an awareness of the costs of
internal harmonization with other research and of the shared services
institutional policies (such as those related that support their institution’s research
to financial, travel, procurement, human programmes.
resources, research ethics, etc.) as well as Where funders do not allow for the
harmonization with national policies and reimbursement of indirect costs, some
research priorities. funding recipients have successfully
Policies and guidelines should facilitate recovered some of their indirect costs by
collaboration and clear communication categorizing those that are linked to a
between different structures or functions particular project as direct costs.
involved in different aspects of applying Generally, recovered costs are
for or monitoring the spending of research distributed between the institution’s
grants. central administration departments, the
Guidelines typically outline the roles environment where the research is being
and responsibilities of institutional conducted and, in some instances, they are
stakeholders, procedures for proposal used to incentivize researchers and support
development, clearance, approval and the development of further research. In
sign-off. They should set out the necessary other words, recovered costs are applied to:
steps involved in setting up, managing and
closing out a grant. In relation to project • Cover administration costs and/or
budgets, guidelines should spell out acquire, repair or renovate buildings or
categories for direct and indirect costs, equipment used for research;
how to apply institution’s standard indirect- • Provide research departments/units with
cost rate, as well as any procedures for the discretionary funds for their own research
waiving of this rate. projects or to enhance their research
Those institutions that report a degree of capacity (including taking on additional
success in negotiating indirect costs with postgraduate students or setting up
funders, ascribe this to their institutions mentorship initiatives for existing staff);
having proper auditing systems and a
FIVE KEYS TO IMPROVING RESEARCH COSTING IN LOW- AND MIDDLE-INCOME COUNTRIES 19
Having experienced an increase in research The database allowed the RSC to calculate
activity over the years, COM realised that its how much money was due to them from these
support systems for the development of new administration fees, and found that they had
research proposals and the management been receiving only a very small percentage
of existing grants were inadequate. They of what was due. The RSC aims to be self-
therefore applied for a grant from NACCAP. funding, and their grant applications usually
Through this grant, and in partnership with stipulate that 10% of the total grant budget
the Emma Children’s Hospital in Amsterdam will go to UNIMA for administration and
and the Liverpool School of Tropical Medicine, overhead costs. To address the reasons for
COM was able to establish its Research the shortfall, the RSC introduced a research
Support Centre (RSC), which now coordinates administration fee distribution policy, and
and supports all of COM’s research set up a research-overheads account to
programmes. receive monies due. To manage the recovery
of overheads, the database is linked to the
Buy-in from management and staff was, Institutional Review Board. Projects are not
and remains, critical for the success of the submitted to the IRB if overhead fees are due
RSC. However, it took time and continuous to COM. COM’s research policy allows for
effort to obtain this buy-in. Buy-in from the overhead fee to be waived in exceptional
COM management resulted in the RSC being circumstances (such as for student projects)
mandated to manage all COM research but approval for this has to be obtained from
grants. Managing research centrally requires management.
a change in mind-set for those not used to
such an approach. Even though it happened A policy for the distribution of recovered costs
slowly, buy-in from the researchers has been has also been developed. To support COM’s
facilitated by the value added by the RSC – objective of creating an enabling environment
the RSC provides a portal through which for research within its own context, recovered
researchers can access specific services and costs are primarily used to support: an
support. The RSC now has a well-established ethics-review committee, the RSC, COM’s
structure and a team of experienced staff. IT and library facilities, a publications
Staff members include a director, a scientific committee, the postgraduate office (that is,
operations manager, clinical research student research projects) and COM’s annual
associates, a trial coordinator, a data research conference. In addition, since staff
manager, a website/information coordinator, retention is a real challenge, some funds are
a grant administrator, a data officer, and an allocated to support a staff-retention scheme
administrative assistant. whereby staff returning from studies abroad
receive a salary supplement and participate
When the RSC took over the coordination of in a mentorship programme. Furthermore,
all of COM’s research activities, it became the COM department that hosts a particular
necessary to develop a governance framework research programme receives a proportionally
for its operations. The RSC facilitated the larger portion of the recovered funds, which
development of a research policy, which they can use to support further research
set out its mandate and operational scope. and to encourage researchers to apply for
Similarly, the RSC established research grants additional grants.
management procedures that streamlined
grant administration into well-defined pre- 1 NACCAP have published a book that highlights the
and post-award processes. Included in this successes and lessons learnt through this programme;
the book is available at http://www.nwo.nl/files.nsf/
was the creation of a database of all grants pages/NWOP_8NMLDS/$file/NACCAP%20Eindboek.
and funds coming into COM. pdf
22 FIVE KEYS TO IMPROVING RESEARCH COSTING IN LOW- AND MIDDLE-INCOME COUNTRIES
skills and mechanisms for attracting and or maintain the necessary infrastructure
managing funds from a range of sources are and support services.
becoming indispensible. Research organizations seem to have a
As institutions’ research reputations limited understanding of how to budget for
develop and they receive funding from true research costs.
an wide range of donors, it can be
increasingly challenging to keep up with
all the standards, templates and reporting
requirements related to grant application Recommended resources
and management that are expected by the
different funding agencies. European Commission Expert Group
Increasingly, institutional co-funding is a (2008) Diversified Funding Streams for
requirement for attracting external funds University-Based Research: Impact of
for research. This, combined with limited External Project-Based Research Funding
or no reimbursement of indirect costs, on Financial Management in Universities.
places excessive demands on institutional http://ec.europa.eu/invest-in-research/
resources. pdf/download_en/external_funding_final_
Pre/post grant training by funders is seen report.pdf
as an important source of support for the
institution but sending staff to the US or
Europe for such training is unaffordable for
research organizations. Such training would
be more effective were it to occur in situ,
within LMICs.
In respect to product development research,
funders generally don’t cover the cost of
the drugs, requiring institutions to seek
sponsorship. The process of first securing
sponsorship and then acquiring the drugs
can delay clinical trials and impact on
agreed timelines.
The following
case studies Botswana Harvard Aids Institute
highlight some of
the institutional
challenges related BHP’s research and training initiatives facilities for data and samples required
to research funding focus on the epidemiology, virology, by clinical trials.
in general, and to molecular biology, immunology, genetics It is difficult to find staff with
the reimbursement and clinical treatment, as well as the experience of managing grants and
of indirect costs in social and behavioural medicine relevant an understanding the implications
particular. The final to the AIDS epidemic in Botswana and that grant funding has on operational
case summarizes the southern Africa. Most of their research processes related to finance and human
indirect-cost policies funding comes from the US government, resources departments, etc.
of various funders. while some funds come from the European The cost of pre/post-grant training is
and Developing Countries Clinical Trials prohibitive if staff have to be sent abroad
Partnership and the Wellcome Trust. for training; for example, the NIH and
CDC offer excellent training opportunities
BHP recently set up a grants management for grantees but it is too expensive
office, and developed a grant submission to send employees to the US for this
policy supported by a grant management training. Thus development of local or
manual. Apart from the general challenges regional training capacity is essential.
faced by research organisations in LMICs
already discussed in this document, such To help build staff capacity, BHP
as inadequate government support and participates in a number of regional
funding for research, BHP identified the networks, including:
following challenges related to securing
research funding and to sustaining their Trials of Excellence in Southern Africa
research environment: (TESA) is a regional network conducting
clinical trials linked to HIV, TB and
As a young organization, BHP has no Malaria, and is funded by the European
discretionary funding; this means that and Developing Countries Clinical Trials
funding agreements have to include a Partnership.
provision for advance funding. Current The Botswana-Tanzania-Zambia Capacity
agreements range from monthly to Building for HIV Prevention Research
quarterly advance payments. Network (TanZamBo) is funded by the
Human-subjects approval – the International Development Research
availability of adequate human resources Centre (IDRC) of Canada.
on the national level to ensure timely The Southern Africa Consortium for
review of protocols; ensuring that staff on Research Excellence (SACORE), a
the National Human Subjects Regulatory/ collaboration between 10 institutions
Ethics Unit and that the members are in Africa and the UK, is funded by
adequately trained to enable them to the Wellcome Trust. When BHP first
carry out their duties efficiently; having accessed Wellcome Trust grants, they
systems in place which facilitate easy were sponsored to visit a prime recipient
submission of material for review of the grant in Malawi to learn about
(standardisation); reducing paperwork the specific requirements related to
through implementation of an electronic managing a Wellcome Trust grant. They
submission system. These should also continue to have annual meetings to
apply to Drug Regulatory Unit (DRU) since discuss any follow-up, challenges and
it is part of the reviewing process in IND a way forward. This model has proven
studies. useful and could be replicated by other
A major gap is in the funding of drugs for funders.
research and for the long-term storage
FIVE KEYS TO IMPROVING RESEARCH COSTING IN LOW- AND MIDDLE-INCOME COUNTRIES 29
The policy on indirect costs at the University sometimes be negotiated with a higher
of Malawi’s College of Medicine (COM) is degree of success.
based on an estimate of 10%. Actual indirect
costs are not known and the institution Nevertheless, between 2007 and 2011, COM
carries any shortfalls that might arise. won an increasing number of competitive
However, COM believes that spending international grants. This can be attributed
time and money on the calculation would partly to the increased visibility of research
be a waste of resources since, in their in the college, and partly to the support
experience, funders apply their own policies provided by COM’s Research Support
regardless. Centre, which has motivated academics to
become involved in grant writing. COM’s
Negotiating with funders for reimbursement successes in winning more grants has led
of the indirect cost rate has not been to improvements in the working conditions
satisfying or successful for COM. They at the college, and helped to attract
estimate that for 98% of grants, funders several expatriate scientists and medical
simply cite their own policies on costs practitioners to return to Malawi.
(that is, funders specified which costs
are capped at a low percentage or not The Research Support Centre’s current
covered) and refuse to engage with the strategy is to try and negotiate for relevant
issue. The remaining 2% of grants are for activities and items to be included as direct
contract research, and for these, costs can costs within the main budget.
30 FIVE KEYS TO IMPROVING RESEARCH COSTING IN LOW- AND MIDDLE-INCOME COUNTRIES
As noted in an earlier case study, the costs. However, in their Global Health
International Development Research Policy and Health Systems Programme,
Center (IDRC), Canada allows for the overhead costs (office space, basic
inclusion of certain indirect costs in project facilities, overhead and depreciation costs)
budgets. The indirect-cost rate can include are allowed at 8% of the total budget only
only: salaries and benefits of personnel for specific parts of projects that take place
who directly support and administer the in LMICs.
project (such as secretaries, clerks,
accountants, etc); stationery and other Since 2008, the European and Developing
office supplies; telecommunication costs Countries Clinical Trials Partnership
(unless the nature of the project has (EDCTP) has allowed for an indirect
warranted a specific budget line item for costs/overheads rate of 10%. This rate
that purpose); and computer equipment is automatically calculated within their
used for the administration or accounting budget template on all eligible costs.
of the grant disbursements. Institutions Overheads are defined as including freight
with a policy of recovering indirect costs costs, bench fees, office rental and other
through the application of a percentage internal charges. Prior to 2008, date the
can do so provided that the IDRC or its overhead rate was 20%. The FAQ section
auditors are satisfied that the levy is fair on the EDCTP website explains that the
and reasonable and that the rate is 13% change was made because ‘some grantees
or lower of the total grant (excluding indicated that 20% of the value of the grant
equipment and indirect costs). going as overhead was not accommodating
to them because there was little benefit
The US-based National Institutes of from the overheads that were taken over
Health (NIH) allows for a limited indirect by their institute, which effectively meant
rate of 8% of total direct costs less the grant was being conducted with 20%
equipment. The 8% is allocated less funding. Now the applicant can itemize
automatically and does not have to be up to another 10% and only 10% goes as
negotiated with the NIH but the funds an overhead, ensuring that the grantee
involved have to be allocated exclusively will fully benefit from the grant’. It should
to support the costs of compliance with be noted that computers and laptops were
NIH requirements. Examples of NIH formerly covered within the 20% rate but
compliance requirements are: the these are now included as line items in
protection of human subjects (including the project budget, as are telephone, fax,
the required education in the protection internet and courier costs. Grantees can
of human research participants); animal request that a lower overhead rate be
welfare; invention reporting, etc. Those applied in exchange for accommodating
items that are more usually considered additional direct costs; right down to 0%
as indirect costs and are relevant to a if required.
particular project (such as rent, IT costs,
etc.) may be included as direct costs within
the project budget.
Now that you have read this guide, what is procedures, as well as the institutional
the way forward? skills and competencies that are required.
Institutional specific factors will predict the
This guide could be useful at various levels. approach and the eventual use of recovered
While it is not offered as a blue print for indirect costs. Moreover, institutions
research costing, using the Five Keys to are at various levels of understanding or
Research Costing in LMICs as a guide or a developing and implementing research
tool in your own institution is important costing approaches – there is no “one size
and potentially of great benefit. fits all”.
In general this ESSENCE Good Practice This guide contains elements that are more
Guide sets out what are currently accepted or less applicable in a range of institutional
as principles of good practice. Your settings. Institutions will consequently
institution can use this to raise awareness select and use those guiding principles
at all levels in the institution of the actual that will allow them to propel from where
cost of doing research. they are now, to the point where they can
In addition it can be used to facilitate more accurately and sustainably cost future
a conversation to reflect on your own research.
institutions understanding and practices. Finally, it can assist your institution to
Using the principles and learning from engage with international and national
others’ experiences can assist you funders on the costing of your research
to identify your current institutional to ensure that it is a true partnership
weaknesses and gaps. with mutual understanding of needs and
The Five Keys guide will furthermore requirements. The Five Keys to Research
provide guidance to developing or Costing in LMICs Good Practice Guide will
improving your institutional management of also assist international and national
external research grants, your institutional funders of all types to assess their
research costing policy, guidelines and practices and policies going forward.
32 FIVE KEYS TO IMPROVING RESEARCH COSTING IN LOW- AND MIDDLE-INCOME COUNTRIES
ESSENCE is ideally positioned to further the To keep the dialogue between funders of
dialogue that started with this study between health research and institutions in LMICs
funders of health research and institutions. alive, and more importantly to have a forum
ESSENCE’s members are committed to for shared learning, ESSENCE has created a
harmonizing their own policies and practices repository of case studies and experiences
as far as possible, and to attempting to better accessible via the ESSENCE website where
understand the needs of research institutions individuals, institutions, networks or
in LMICs in relation to establishing professional bodies can post challenges and
sustainable research environments. share experiences on the issue of research
costing. The repository is primarily for use of
In this good practice document, case studies research institutions, to help them identify
are linked mainly to experiences of research common challenges and to learn from their
institutions in sub-Saharan Africa. The next successes and failures. ESSENCE members
step is to canvass the views of institutions will also use specific challenges and demands
in other LMICs on whether similar issues are coming from the postings to help inform
relevant to them and to find out if they have further harmonization of their own practices
other good practices to share. in relation to the needs of funding recipients.
Should you have any information you would like to share with us please go to:
http://www.who.int/tdr/partnerships/initiatives/essence
On accessing the repository you will be able to submit your post on a template provided.
TDR/ESSENCE/1.12