> epinibion i oa > General eachin > Gonoml Peckenitn _ Faonplei vith Preckan etd. @ Condition 4 Yeadon. ° Substrate. => Promples with geution © General PAGS eo Applications in industry. 1- Phormacertica) rial herecica) Prafeel Seienn Food Dye D Ei /evites 5pm. Le “Ccobucton 2- 3- + © 6- 7-Wye fe teutlion —_bolween atdehpde]ketons and a Compound Content cehve _rnehiflens pup fats. presenes 8) — Orqunic__buse to fom Xo 2 ‘pet tureeed| Compounds? Se tose ealatyl which are Used gencsettly we Wis derivative Dike BiH, Pall, Ral'» Bridie and __piperid'ne_ete — — Re Amita base i} — 4—_ 29 _=+o S Zt Zo. Zi» Zo = CR » COK , CHO tN »NO ole. ketone Ack ivecbectad! nttyflenn x, 8 Unsetfreted ate histoy eh ths reaction gees back £0 1890 when te _enexs weported by eLormenn chemist Erie Lnoevenegyele a The beso fowl zs Led — inf, veeetion (fae end G rts dem'rethive»Step ios Deprstonetion of ye _activected methylene by Hr bose fo giue__@ Qurbenton whith _t¢ Labeliged Via enolate jon ft a > Resonne Soblyed Earlooenior, P } == Rahn CHHooe —CH—< aX Hooc —th —éy Coors + Hool—CH ac COokt H30™ 5 cont — coo: J Deca. HOC —CHH=C Hone —H) = tH —tooh alee —ceoyG2) Con. Kou = 5 —coey 0) W]e Sa Ore Ne -blaleDate: Sip ae ink ahealeada Ue. Corker Gurhon @) tie eltdohyte botons. te Conditions for Kaveveng of Zndonsepion ane aw fallow. “aitehych or Keone Gateminy k- Mydheyen acorn. pete naihykns —_Gmpund (cts) Shutd be present 4 a Gryppund . Catalyst Cpiperidne by p wikne) ae tlsods weyshy baste Lentition fo _aveld formation _&f enolate At Loust dre mtfente of the reactent Yoold he o70 Digeuble. Polen aprotic Levent (euch ag OMS» DMF ox ceolore.) high temperctle € too -1¢0°e) presere —_yeyuived Te presen awe __ tant’ bon Cortedyet meg, wediee pe ond Lombmes on ate yold gy He reache Miphatc ord — ayomelie elite hyeh reurtion — yrare cay, fon _jxtfoneThe yeason for _veaetiviy 6A _felow —_powewd ne everag oh t veuttogn te", Spear _hindoranee _feefone ane Ness aemtive in ws Cupp dees 70t Undergo _ nuclear addition _veathon _oas'ly« 7 ? —ott —e ott y — ft el L 6 . WV DEM Piyjenjoujuse YY 2 ano Hy Aldohyf. Kofune. Yue the _etive _matlyhne Conforiny powerfull withdrautay group sue abhryenerfocrerfarte er“ eyernooxetf ie aid “hejons Con _prve fyoeveneey@) youll ory spowertly el dahyds being more _aeaehve then kefore give youtt ton tae on active mnofrglene _ Qmpound _infha bee, eae Ray 3-Benpyliden -~ 994~ pentarnedionspyridine A on ppertiox ue on tye, Oe, A Cimnamie abd 1 why ule Use aoe bege 2 Ts_veason 00 fet, wanfe hase easily dyptforate —— autve _yrotbylue _Lampound Lie che’ AMC atithe_Y -aten), ond _ baron" it into _neeleaphife whith forfer ret! with ald x fofane oa a, BP Unsateated Lypeund. we the tprony bee fare ase ehaees BY Condenetion aldlyt. 2 fafonee, :of boy Self Gntensation don't Chen dening qpeatfan 2 Because Jor Sebf Centensalon spony bute fe areyofied and we the weak bese prfphe cpentt fio”03 wihy we Use Polar * Polar Gach oe OME (NeN- dnedhylformetinte) 5 D/2G0 ( drmelyleolforide), and aecfane Cun _erhonee the yee oA aprotic Lolvent 2 eprite Galvan reuttion » BT fs heeawse _ pose wotermadiele enolate jon by ite prtfencttions Tr facile ectos end preven the noevenyl _Condan tection Loluon t Gn Goletfion Mk. Hablize phe bf and mein Of old Gf, either never predict # Te knoewpel tondanteton i en me ‘Sothsir Of aw with Goch a antrbjotics_» adfivivels » enficantes 20 5 ond anti - inf vometlony ents: + For example:— Jia. Gales oe ang rab rotreet te Anoeverg —yenthon bo jxtodues H_ Agrochemical Indasfry.— exenfial rexttion biactttye vange — yy mefeate enpleys fhe We _polic arid motif * Te fnowenpel —renchon erifreal Sep tn ha Syrlhost Of Vartous pedrekls herbi cies e_and _jncoclicies. foe eh awitely Used herbieite. ghyphesale jnvelver. Sequence. Y__ knoewengel — yeartions |e Te Q al Seince Te kaoovengel yeattion 0 be thal Syothesi72 —_palymeme — mattentels , nel pelyirril cand peyester ptt hve —_eppfrrathans in __ndostries ath as acrogur —_ alettronieg, oe _—_aathingye 7 WW Food Indusfry.. Ta reutions alo pind its appl eation ins good indluifay » Tee Synttosis of ethral fod additives Such as Comma _» vanillin lund Cmamalbhyle. Con be _cceonptrited Using f_knowergld veactione J -S Indvsry. Te knoovengl venetion ic Yeed fo Synflasis vorrous byes that pint op Mecef itn, jola fertile sndusf, 7 De Lert — Man’. Zompornty nwa fsnoeverge] —_géxafon hoy been D Semployed tote fubviection Of) __onengy _sporage devi’ Lech op batteries — gan Heel Cel. beanie. Semian Quelore.- Ralymerit —__ Lemitonthefarc, whith are a cles af" melonak Cupabh af Cangn high Cnet » bur be Lyrhesrzod foto gh Krowergd youtfions » Tere _mefer'ed, ind — yunbows appliecttion infe vedeedlien fe bectven produc both a Soft elle ~— onsors and ahetbanie displays.