Professional Documents
Culture Documents
12mihailidis ElectronBeamDosimetry
12mihailidis ElectronBeamDosimetry
Approach
in
n
Clinical Electron Beam Dosimetry
Clinical
PROGRAM DIRECTORS
D
David W.O. Rogers,
R Ph.D.
Joanna Cyg
yg
gler,, Ph.D.
g
AAPM & SS
S SubCom
Local Arrangeme
ents Committee
Ms. Betsy Phelps
Phelps-
h l -Medidicall Physics
h Publishing
bl h
Participants
OUTL
LINE
Objectives
Current calibration protocols
E-beam quality specification
n
Measurement of CA %DDs in water:
water:
– ion
i chambers,
h b di
diodes,
d fil
film
– practical rules
Output
p factors
Non
Non--water phantoms: Relattive measurements
– ion chambers, %DDs, film
Smallll and
S d iirregular
l fifield
ld d
dossimetry
i t
Extended treatment distanc ces
Electron algorithms
Some data and examples
Objec
ctives
Address the issues that currently influence the
dosimetry of clinical elec ctron beams due to
changes recently introdu uced by the new
dosimetry calibration pro otocol (TG(TG--51).
Suggest how to approprriately modify and update
the widely accepted TG-
TG-25 electron dosimetry
protocol.
Describe a detail proced dure of converting
measured depth-
depth-ionizatiion curves with ion
chambers into depth
depth--dosse curves making use of
recently published stopp ping--power ratios and
ping
other conversion factors s.
Present the important po oints of the upcoming
AAPM TG-
TG-70. (Gerbi et al. Med.
M Phys. July 2009, issue!)
Objec
ctives
Describe the use of wate er equivalent phantoms
to perform relative electrron dosimetry based on
recently published conve ersions factors.
Discuss small and irregu ularly shaped electron
field dosimetry using the
e concept of lateral
buildup ratio (LBR) as an n avenue to evaluate
electronic equilibrium an
nd compute dose per MU
for those fields
fields.
Give some common clin nical examples where
electron beam dosimetry y is applied.
Important rep
ports to have
TG
TG--25 (Clinical electron beeam dosimetry).
TG
TG--51 (protocol for clinical dosimetry for high
high--
energy photon and
d electron beams).
TG
TG--69 (Radiographic Filmss for MV Beam
Dosimetry).
TG
TG--39 (The calibration andd use of plane-
plane-parallel
ionization
ioni ation chambe
chamberrs
s fo
for dosimetry
dosimet of
electron beams) .
TG
TG--53 (Quality assurance for clinical radiotherapy
treatment planning
g).
TG
TG--106 (Accelerator beam
m data commissioning and
procedures.
TG--70 (just published)
TG
Current calibra
ation protocols
ation
Current calibra
ation protocols
TG
TG--51 of AAPM (19999).
999)
TRS--398 of IAEA (2003).
TRS
“Absorbed
“Ab b d Dose
D determin
d ination
i iin E
Externall B
Beam
Radiotherapy: An Internaational Code of Practice
based on Standards of Abbsorbed Dose to Water”
Code of practice off IPEM (2006).
“Code of practice for elec
ctron dosimetry of
radiotherapy beams with h initial energy from 2 to 50
MeV based on air
air--kerma calibration
calibration”
”
Main objectivves of TG-
TG-51
DefinesDose at one poiint, dref.
Proposes to do two thin
ngs:
1. Incorporate the new abs
sorbed dose standard
– Absorbed dose is more robust than the Air-
Air-Kerma Std.
60 Co
Q
N D ,w k q N D ,w
– Dose to water is closer to the dose to tissue
2. Simplify the calibration formalism
f (as much as
possible)
Makes use of realistic water-
w
water-to
to--air restricted
SPRs
SPRs. w
L
air
Because of TG-
TG-51 1 (and other recent
dosimetry data), do
o we need to modify
TG--25 ?
TG
YES! TG-
TG-70 was charged!
E-Beam Qualitty
ty Specification
Electron Beam Qu
uality Specification
New beam quality specifie
er*:: R50 (depth in water
er*
at which dose falls to 50% of maximum for
large field size (>10x10 cm2) (TG
(TG--51).
First find I50 (50% of ionization maximum).
or
*(TG--25, be
*(TG eam quality specifier: (Ep)0)
Energy at
a depth
Harder’s Eq. still valid!
v (Harder 1968)
d
Mean energy at depth: E d E 0 1 ( MeV )
R
p
M
Mean energy att surface
f off phantom
h t : (IPEM 2003)
R p 1.271R50 0.23(cm)
Energy at
a depth
Harder’s Eq.
q still valid!
v ((Harder 1968))
Mean energ
gy at depth:
d
Ed E 0 1 ( MeV )
R
p
? ?
Energy at surface and
a practical range
Mean energy at surface
e of phantom : (IPEM 2003)
R p 1.271R50 0.23(cm)
Comm
ment
Harder’s Eq.. still valid!
d
Mean energy at depth: E d E 0 1 ( MeV )
R
p
U off ((as off TG-
Use TG-25):
25)
• Apply TG-
TG-51 requirem
ments for Pion and Ppol
(For %DD: measure att I50 and Rp depths)
M (d )
% di ( d ) 1000
M ( I max )
Step
p 3:
3: Use realisttic SPRs water/air
From Burns 1996 (in water)
w
w
L
( R50 , d ) Pfl ( Ed ) Pwall (d )
.
air
%ddw (d ) %idw (d ) w
a
L
( R50 , dmax ) Pfl ( Edmax ) Pwall (dmax)
air
Errors associa
ated with SPRs
Fitted SPRs vs.
vs individually calculated
Error:
% of Max dose=
%error
% off th
the fitted
fitt d
SPRs vs. individually
calculated values.
Rogers
g has shown that
the %DD can be
R
Rogers, 2004 determined to within
1% of the dose at dmax.
(Rogers 2004)
Reminder:: For
Reminder F electrons
*where
Ed E0 1
1 d / Rp
Pwall
w ll
Pwall=1:
1 for
f electron
l t beams
b and
d llow-
low-Z thin-
thin
thi -walled
ll d
chambers (Johansson 1978)
Recommendation: make
Recommendation: e sure your chamber
introduces less than 2%
% error at depths by
comparing its response to published data.
p-p chamb
chambers
ers in water
Use of p-
p-p cham
mbers for %DD
• In general, front of window is point of measurement
Front window thickness ((1 (1--2mm)) should be taken into
account.
Pggr=0 for all p
p--p chamberrs.
Pfl=1 for most chambers except Markus and Capintec
PS--033 (use TG
PS TG--39
9 for correction factors).
Pwall corrections are conssidered negligible in most
cases.
Pwall:
Recent data (Buckley&Rogers 2006)
2 have shown strong
depth dependence for NACP-02, Roos, Markus and
Capintec PS-
PS-033.
Buckley&Rogers
s: p-
s: p-p chambers
Recommendation:
Recommendation:
C
Compare your chamber’s
h b ’
response with data from
lit t
literature tto be
b <2%
2%
The effective p
point of me
easurement is the dye
y
(get specs from manufacturer).
ABOMINABLE (A
A-Bomb-In-A-Bull)
A-Bomb-In-A-Bull)
Courtesy of J. Gibbons, PhD
General Characte
eristics of E-
eristics E-%DDs
definitio
ons….
Practical Range
Therapeutic Range
ICRU 35 (1984)
As Energy increases
Surface 5mm) ↑.
dose (at 0.5
dmax ↑ for lower Es and
a stops at
moderate/high Es.
Beam penetration ((d90, d50 and Rp) ↑.
x-ray contamination n ↑.
As beam energ
gy increases….
gy
Hogstrom (2003)
As field size
e decreases
9 MeV 20 MeV
Hogstrom (2003)
Outputt factors
Defin
nition
SO:
USE WATER
R WHENEVER
POSS
SIBLE!
Use of non-
non-wa
ater phantoms
di
discussion
i of corrections
i
Depths need to be sc
caled.
Chamber
Ch b readings
di ne
eed d to
t be
b multiplied
lti li d b
by
an appropriate fluencce--ratio correction.
ce
Stopping
Stopping--power ratio
os should be taken at
the scaled depth.
Charge storage effeccts should be kept in
mind usinggppolystyre
y y ene and PMMA.
Correction
ns needed
R50
w
Depth correction: d w d med eff d med med
R
50
)L / w
D w ( d wmax ) maax
D med ( d medd coll med med
w
w
(d max
med ,r) med
Se,w (d max
w r) Se,medd (d
,r) max
m
md
med r)
,r) w
(d max
med ,r0 ) med
med
w
: Use data from Ding
D g 1997.
1997.
• p-p chambers:
h b Pfl=1
1
• Film XV
XV--2 ((TG-
(TG-25))
Large energy dependence
Dosimetry
y of small
an
nd
irregula
ar fields
Dose determination in
n small/irregular fields
Inherent problems in
n dosimetry of small
electron fields
– depth of dmax become es shallower.
shallower
– the output factor may y be significantly
different than the con ne factor if the field size
is small enough for la ateral scatter equilibrium
((LSE).
)
– isodose coverage is re educed in all directions
as the field shrinks.
Square--Ro
Square oot Method
For rectangular fields off X & Y dimensions:
S e (d m , rX ,Y ) [ S e (d m , rX , X ) S e (d m , rY ,Y )]1 / 2
Hogstrom (2000)
Comparison of the percent differrence between measured and
calculated output factors for commmon methods of calculation
in the literature.
literature The measured anda calculated output factors
were for cutout shields that were e shaped as squares,
rectangles, circles, ellipses, and arbitrary shapes used in the
clinic
(Jursinic 1997)
Lateral Buildup Ra
atios (LBRs) Model
(Khan ett al. 1999)
THE WRATH
H OF KHAN
When is special do
osimetry required?
When the minimum field dimension is less than
the
th minimum
i i radius
di off a circular
i l fifield
ld that
th t
produces lateral scatte er equilibrium (LSE)
R eq 0 . 88 E p , 0
or
a 1 . 58 E p , 0 (Khan&Higgins 1999)
where
E p , 0 0 . 22 1 . 98
9 R p 0 . 0025 2
Rp
Do you remember what it has been?
From Lax&Brahme (198 80) we have been using
th criterion
the it i ffor LSE:
LSE
E0
R eq
2 .5
wherre
(also in Khan’s book)
E0 E0
or
E 0 E p ,0
Pencil beam…
b
Broad field
field--same surface fluence as pen
ncil
beam
r2
exp
r ( z)
2
Due to multiple
p
d p ( r , z ) D (0, z ) Coulomb Scattering
r 2 ( z )
Khan et al. (1998)
LBR de
efinition
LBRs are related to r2 d mean square radial
spread d off pencil
il beam
b (independent
(i
( d d t off fi
field
ld
size).
DEFINITIION of LBR:
D(d , rx ) i (r , E )
LBR (d , r )
D(d , r ) i (r , E )
rx: s
small
a fieldd (e.g.,
( g , 2 cm
c radius)
ad us)
r∞: broad field (e.g., 20
0x20 cm2)
(…): incident fluence (normalize at 0.5 mm
depth)
(Khan et al. 1998)
Measured PDDs norma alized at 0.5 mm depth
(surfface)
Diode data
1: 2 cm
2: 2.8 cm
3: 3.7
3 7 cm
4: 5.8 cm
rx2
r2 (d )
1 w
with LBR<1
ln
1 LBR ( rx , d )
LBRmin
Khan et al. (1998)
In which applicator to use the rx field?
6 MeV 12 MeV
It does NOT
matter!
20 MeV
2 cm diam. insert in
10x6, 10x10 and
20x20 cm2
applicators
For irregularly shaped
s fields…
Sector integration summing
g the pencil beam
contributions.
n ri 2
LBR eff (d , r ) 1 ( ) exp[ 2 ]
2 i 1 r (d )
ri
θ
x
O
(Khan&Higgins 1999
1999)
Can we predict dmax
m for small fields?
rx
d max
0.174rx 0.67
E 1p.,67
0
2 0.33
0.06225E p ,0 rx ≤ Req
Relative applicator
Compute output factor: Output Factor
S e ( d , r j ) S e LBR eff ( d , r j ) % dd ( d , r )
(Khan&Higgins 1999
1999)
Data vs. predictions for
f small circular fields
dmax
(Khan&Higgins 1999)
Data vs. predictions for
for small circular fields
Dose
MU
Use TG-
TG-25 reccommendations.
Beam ooutput
a
at
extended distances
Io: Rdg
d at SSD
SS nom
I: Rdg at SSDextt
SSDnom: 100 cm
10x10 2x2 0.9 0.791 33.1 10x10 2x2 1.2 0.893 58.7
" 3x3 1.2 0.870 46.6 " 3x3 1.6 0.918 66.4
" 4x4 1.4 0.957 55.4 " 4x4 2.0 0.944 62.5
" 6x6 1.4 1.001 61.5 " 6x6 2.6 0.987 71.5
" 8x8 1.6 0.998 73.6 " 8x8 2.9 0.995 79.1
5cm 5cm 1.5 0.817 57.3 5cm 5cm 2.7 0.922 82.0
10x10 10x10 16
1.6 1 000
1.000 83 9
83.9 10x10 10x10 29
2.9 1 000
1.000 94 2
94.2
15x15 15x15 1.6 0.998 99.4 15x15 15x15 2.9 0.984 103.5
20x20 20x20 1.6 1.001 100.4 20x20 20x20 2.9 0.957 104.6
25x25 25x25 1.6 0.992 106.0 25x25 25x25 2.9 0.957 106.9
(Mihailidis, et al.)
Weak dependence of SSD
S eff on applicator size
(Varian 2100 Data)
6 9 12 16 20
Avera
age (Roback et al. 1995)
Output at exten
nded distances
S e ( d m , SSDext ) S e ( d m, SS
SD nom ) GF
2
SSSDeff d max
GF
with SSD
Deff d max g
D prescription
Monitor Units: MU
Se (d m , SSDext )
NOBLE (No-Bu
ull)
ull)
Courtesy of J. Gibbons, PhD
Electron Beam
m Algorithms
g
(Simple discussion)
General C
Comments
What should be done too commission these
algorithms (being consistent with TG53)
– know the pitfalls and limiitations of electron
algorithms
– careful with normalization of dose distributions for
electron
l t algorithms
l ith
Restricted field
Extended treatment distance
Inhomogeneities
o oge e t es in elec
e ec
ctron
ct o treatments
t eat e ts
– The effects of inhomogen
neities on dose distributions
– Computer representationn of the effects of dose
inhomogeneities
Use of bolus
Field abutment
– Electron-
Electron-electron, with sa ame or different energies
– Electron-
Electron-pphoton,, with sta
andard or extended distances
– Tertiary shielding for field
d abutment
Library of clinical treatm
ment examples
Acknowle
edgment
Members of TG-
TG-70 group.
g
Faiz Khan.
Dave Rogers.
Ken Hogstrom.
Hogstrom
Bruce Gerbi (Chair of
o TG
TG--70).
Not do
one yet
Stay where
e you are!
The Duke
Prob
blem
2.25 cm radius
Solu
ution
Check
Ch k for f LSE first.
fi t In
I pra actice
ti cm and d Ep,0=16.2
16 2 MeV
M V
(from (12.19)). Then, Req=3.5 cm (eq. (12.18)), thus
no LSE since a diam=7 cm m will be required.
Need
N d to t find
fi d new dmax tha
th t is
i shifted
hift d towards
t d the
th
surface. Use either film dosimetry
d with film placed
parallel to electron beam in solid water or plane- plane-
parallel chamber in solid waterw with thin sheets of 1
mm to measure the dmax. An estimate of expected
dmax for the 5.5 cm diam. field is: 2.8 cm (from
((12.24)).
))
Measure the output factorr of 5.5 cm field at 2.8 cm
(new dmax) relative to the reference 10x10 at 3.4 cm,
both at 100 SSD.
From film or plane-
plane-paralleel chamber dosimetry find
dmax, d90, d80 and at those e depths measure isodose
lines with film perpendicular to beam in solid water.
S
Scan films
fil in
in-
i -plane
l andd crross
ross--plane
l to get the
h widths
id h
of 95%, 90%, 80% and 50% isodose lines at the
above depths.
THANK
K YOU!
Now, let’s
let s go forr a brew or two!