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Eid 2016
Eid 2016
Eid 2016
J. Francois Eid, MD
ABSTRACT
Introduction: Over 25% of the more than 725,000 cases of nosocomial infection in the United States are related
to an implantable device. Despite the standard typical strategies available, infection rates for breast implants,
cerebrospinal shunts, and penile implants remain unacceptably high. This paper will review use of a “no-touch”
technique in varied surgical procedures from orthopedic fracture repair, cerebrospinal fluid shunt placement, and
breast reconstruction/augmentation to penile prosthesis implantation.
Aim: One of our aims was to investigate whether the “no-touch” concept was unique to the field of penile
implants and if similar results were obtained in other subspecialties. The other was to examine whether the low
infection rate initially obtained with the “no-touch” technique was maintained for a larger number of penile
implant procedures.
Methods: The literature was reviewed for the use of the “no-touch” technique in procedures as varied as
orthopedic fracture repair, cerebrospinal fluid shunt placement, breast reconstruction/augmentation, and penile
prosthesis implantation. In addition, a single surgeon’s experience with 3342 penile implant surgeries with and
without the use of the “no-touch” technique was reviewed.
Main outcome measure: Penile implant infection rate was examined for 3342 consecutive cases between
January 2002 and December 2014. Infection of standard technique was compared with rate of infection with
antibiotic impregnated devices and starting in 2006 with the addition of the “no-touch” enhancement.
Results: Literature review revealed that the “no-touch” technique decreased postoperative cerebral shunt
infection from 9.1% to 2.9%. Breast implant reconstruction surgical site infection decreased from 19% to none
with the “no-touch” technique. Penile implant infection rate fell from 5.3% in 2002 to 1.99% with the use of
antibiotic impregnated devices and to 0.44% with the addition of the “no-touch” technique.
Conclusion: Use of a “no-touch” technique involving a mechanical barrier makes a difference in preventing
infection of an implantable device.
Sex Med Rev 2016;-:1e7. Copyright 2016, International Society for Sexual Medicine. Published by Elsevier Inc.
All rights reserved.
Key Words: Penile Prosthesis; Surgical Technique; Infection Prevention
Table 2. Infection rates of virgin and revised implants by IPP type and surgical procedure
Virgin implants Revised implant Total
Patients were examined or contacted at 2, 4, and 12-week, and and a total of 2506 implantations (626 AMS, 1880 Coloplast)
then 6 and 12-month intervals. performed using the “no-touch” enhancement over the next 9
A total of 3342 penile prostheses were implanted between years starting in 2006. Primary implants accounted for 2038
January 2002 and December 2014 as summarized in Tables 2 cases, whereas 468 were removals and replacements. Since 2002,
and 3. The data are divided into 3 distinct periods: (1) during the AMS 700CX and LGX accounted for 959 cases, AMS
2002, the prostheses used were neither coated with infection Ambicor devices, 2 cases; 2335 cases used Coloplast Titan de-
retardant nor implanted using the “no-touch” technique vices and 46 cases used Coloplast Genesis semi-malleable devices.
(n ¼ 132); (2) from 2003 through 2005, the prostheses used The Genesis was used for cases with severe fibrosis in which
were coated with infection retardant, but the “no-touch” tech- corporal dilation to 13mm was not possible, and 43 were later
nique was not used (n ¼ 704); and (3) from 2006 through 2014, converted to an inflatable device after a 3-month period.
the prostheses used were both coated with infection retardant Of the 132 patients implanted during 2002, 7 developed
and implanted using the “no-touch” technique (n ¼ 2506). infections, reflecting an infection rate of 5.30%. Cultures of the
infected patients grew coagulase-negative Staphylococcus (n ¼ 3),
Type and Brand of Implants Enterococcus faecalis (n ¼ 1), or had no growth (n ¼ 2). Of the 704
Of the total 3342 implantations performed over a 13-year patients implanted from 2003 to 2005, 14 developed infections,
period, 132 (85 American Medical Systems [AMS, Minne- reflecting an infection rate of 1.99%. Cultures of the infected
tonka, MN, USA] and 47 Coloplast [Coloplast, Minneapolis, patients grew coagulase-negative Staphylococcus (n ¼ 3), Staphy-
MN, USA]) were noncoated in 2002; there were 701 coated lococcus aureus (n ¼ 1), Enterococcus faecalis (n ¼ 1), or had no
implantations (250 AMS,454 Coloplast) from 2003 to 2005; growth (n ¼ 10). Of the 2506 patients implanted from 2006 to
2014, 11 developed infections, reflecting an infection rate of further reduction of infections. Although the iodophor-
0.44%. Cultures of the infected patients grew coagulase- negative impregnated drape has been shown to be effective and is used in
Staphylococcus (n ¼ 3), Enterococcus faecalis and Candida (n ¼ 1), our technique, it is not used as a skin barrier. Because the iodophor-
Escherichia coli (n ¼ 2), Lactobacillus acidophilus (n ¼ 1), and impregnated drape has an adhesive backing to it, it restricts the
Enterococcus faecalis (n ¼ 1), or had no growth (n ¼ 3). The total necessary intraoperative manipulation of the penile shaft and
infection rate significantly decreased between the first 2 periods scrotum. With the loose surgical drape used in the “no-touch”
(P ¼ .0350) and between the first and third period (P < .0001), as enhancement, the barrier function is preserved, while allowing
well as between the second and third period (P ¼ .0002). mobility of the penis and scrotum. This mobility is essential to
manipulate and examine the shaft of the penis flaccid and erect
DISCUSSION after cylinder insertion as well as to inflate and deflate the scrotal
pump. Because the tissue spaces for the components are fashioned
The use of a “no-touch” technique during surgeries as varied
without contact with the patient’s skin, contamination of the intra-
as orthopedic fracture repair, cerebrospinal fluid shunt place-
cavernosal, scrotal, and space of Retzius is thought to be minimal.
ment, breast reconstruction/augmentation, and penile prosthesis
Also, because the components of the devices are prepped and
implantation highlights a common concern about contamination
implanted by gloved hands that have never touched the patient’s
of implanted devices by skin flora. Although modification of a
skin; the contamination of the implant with organisms from the
device surface to inhibit bacterial presence in the biofilm (ie, with
patient’s skin is thought to be negligible. Lastly, another unrec-
an microbial coating or other type of infection retardant) is one
ognized benefit of the “no-touch” technique is that it allows for
of the most commonly used methods of preventing device-
intraoperative repositioning and/or length adjustment of the
related infection, its success appears to depend on variables
cylinders with minimal exposure to skin flora. A drawback of the
such as device location, type of infecting pathogens, and coating
“no-touch” enhancement is that it increases the cost of the oper-
agents used.2 However, improvements in the incidence of in-
ation to a mild degree by requiring duplication of some
fections caused by the use of these coated devices is further ev-
instruments and supplies, and increases the operative time by
idence that bacterial contamination occurs during implantation
approximately 10 minutes. When compared with the pain and
and provides an incentive to develop a surgical technique which
suffering as well as the substantial cost of an infection in both real
completely isolates the skin from the device. The first publication
money and emotional distress on the patients, these increases
on the use of the “no-touch” technique for penile prosthesis
appear to be trivial. Although data to date strongly suggest that the
surgery was published by the author in 2012 to explore whether a
use of a “no-touch” technique involving a mechanical barrier
“no-touch” enhancement to the penoscrotal surgical approach
makes a difference in preventing infection of an implantable
further reduced infections beyond the use of coated implants.15
device, it does not unequivocally prove this hypothesis. For
In the case of inflatable penile prosthetic implantation, aug-
example, other variables, such as improved surgical technique over
menting the use of a coated device with a “no-touch” technique
time, could potentially explain the decrease in infections, regardless
appeared initially to further reduce infection rates from 1.8% to
of the use of the “no-touch” technique. A study in which patients
0.46%.15 The current review aims to examine whether this low
are randomized to receive an implanted device using either a
infection rate could be sustained for a larger number of implant
“no-touch” technique or a more traditional surgical technique
procedures. For the next 4 years the total number of implanted
could help further elucidate this issue; however, it would not be
patients increased from 1511 to 2506 and the infection rate
possible to blind the surgeon to the procedure used. Nevertheless
remained at 0.44%. In addition a review of the literature on the
our 9-year experience with the “no-touch” enhancement in 2506
use of the “no-touch” technique in other types of surgeries was
consecutive penile implant procedures has achieved an unprece-
made to further support its use for penile prosthesis implanta-
dented low infection rate of 0.44%. This is currently the lowest
tion. Indeed, similar results have been reported in the fields of
infection rate reported in the literature.
orthopedic surgery, neurosurgery, and plastic surgery; however,
many of those studies were published more than a decade ago.6,8
Corresponding Author: J. Francois Eid, MD, 435 East 63rd
Prior to the use of infection retardant coating, skin flora (eg, Street, New York, NY 10065. Phone: (212) 535-6690; Fax:
S epidermidis) appeared to be responsible for approximately 65% to (212) 535-7025; E-mail: jfeid@advancedurologicalcare.com
75% of infected urologic devices.17,18 Subsequent research Conflict of interest: Dr Eid receives or has received research
suggested that the introduction of infection retardant coating support/grants from American Medical Systems (AMS), Colo-
primarily targets these organisms, but not infections caused by plast Corporation, Lilly ICOS LLC, Bayer, Vivus, Pharmacia-
Enterococcus, S aureus, E. coli, and Pseudomonas.19 Indeed, the data Upjohn, and Pfizer Inc. He is or was a consultant and on the
in Table 3 reflect an increase in some of these less common, albeit speakers bureau for Coloplast, AMS, Lilly ICOS LLC, Bayer,
more aggressive, skin pathogens during the periods when patients and Pfizer In.
were implanted with devices coated with infection retardant. It was
logical, therefore, to explore the use of a skin barrier to attempt a Funding: None.
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