chemical transmitters

fibers acetyle choline

motor chemical transmitters motor system
system

involuntary voluntary

acetyle choline

noradrenaline

CNS
central fibers CNS

peripheral fibers ganglia

central and peripheral

skeletal muscles somatic central

autonomic"preganglionic"

sympathetic parasympathetic peripheral

*postganglionic

preganglionic autonomic central

central cholinergic fibers

acetyl choline central

 parasympathetic peripheral
sympathetic

sweat glands and blood vessels of skeletal muscles

central
central fibers

action potential somatic

postganglionic preganglionicJ AP preganglionic autonomic

transmitter

peripheral

transmitter central
transmitter peripheral

exception
sweat glands and blood vessels of skeletal muscles
skin sweat glands
glandsJ
 wall limbs BV of sk muscles
transmitter

noradrenaline

secretomotor system secretion

sweat glands sympathetic
fight
D

vasodilatation
sweat glans and BV vasodilatation vasoconstriction
of sk ms

transmitter acetyl choline

receptor fiber

central fibers central cholinergic receptors

peripheral fibers peripheral cholinergic receptors

central cholinergic receptors

motor end plate

 postganglionic neurons ganglia

peripheral receptors

supplied by postganglionic parasympathetic organ

sweat glands and BV of sk ms organs

supplied by postganglionic sympathetic

How many types of cholinergic receptors you know?????

I know 2 receptors and each has got 2 sites

The central cholinergic receptors ( sk ms and ganglia)

----------- and the peripheral cholinergic ones (all organs supplied by

parasympathetic and 2 organs supplied by sympathetic

motor system transimitter

one exception ) postganglionic sympathetic

exception

sweat glands and BV of sk ms exception

somatic

preganglionic sympathetic

exceptions of post ganglionic sympathetic

 central
nicotinic receptors cholinergic receptors

peripheral cholinergic receptors

musccarinic receptors muscarinic

key and lock theory receptor

stimulus receptor

receptor
blocker

stimulus or blocker receptor

. receptosr.-----} ( nicotinic and muscarinic)

drugs----} ( nicotinic and muscarinic)

muscarinic receptors muscarine drugs

parasympathomimetics

postganglionic parasympathomimetics
sweating sweat glands and BV of sk ms sympathetic

anticholinesterase muscarinic receptors

parasympathomimetics

anticholinesterase

blockers
nicotinic and muscarinic
muscarinic blockers : (all organs supplied by para and 2 organs supplied by
symp

atropine paralytics

atropine

bronchi

pupilodilataion

nicotinic blockers

somatic : (neuron muscular blocker

curare

ganglia : nicotinic large dose & tetraethyle ammonium

stimulus nicotinic small dose

adrenal medulla
ganglia blockers

prevent the action and not the formation of blockers

acetylecholine
 noradrenaline transmitter
adrenergic nerve
sweat glands and BV of postganglionic sympathetic fibers
sk ms

Formation of adrenaline and noradrenaline

amino acids ) ==< phenylealanine ==< tyrosin ==< dopa ==<

dopamine ==< noradrenaline

CO2 OH

noradrenaline adrenaline adrenal medulla

N methyle normal position methyle group
transferase

N methyle transferase

Inactivation of noradrenaline

active reuptake

active

diffusion to extracellular

adrenal medulla

brain kidney liver oxidation : MAO

adrenergic nerve
 O methyle transferase methylation
liver kidney

schizophrenia

MAO
inhibitor

malania

Adrenergic receptors