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CHEMOTHERAPY UNTT-2 p'colaqy

Tihoduction Genral puindpla s of dumotnuapy

a
Clastificatim (Sulfonamidus
Acc. to Sunje Xom

rm
Ari biohits and RaciC nouledg9

Defint dhunothunapy Qnd write s guna piniplw

ChLmotapy
ha
(Chuno)+ Hapyy.
lP
ktmdcaly Hestmunts eatmint of
infechous dusAales
el

chwia whith u Coused

du
duas ay (Moooganiem
ew

Chumothapy typa OfF

tecdtmnF which aL
ud
in
HauntF of Canir and infectiovs
dista
ar

which CaUSAd
du Typ of Mogalyn
Chumotuapy
C

Auticanur dAugs

Avti-rmioobial
dhugs
thst a hosa dA whch bilu
O inhi bit
th grouwth
of MCOOrganlam
T Syllalu
(AHso Hhuy obtaind fom ay typa of
micOOojahlina).

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pvincpll » amun of infechious dicaa by
destroying mco ougalsm with ninimum 4ffcc /dama4A

hosF cols /patiets

rcro ogoul

a
DRUGS

rm
natua
obtaind
ftom auy typ Sytuhic ChumO

ha hosF
Col
rotieu
Unim
lP
History
em chmothrapy fint Cofnd

Paul Ehvlich
el

He Enoun t fathr of chunotheAapu

fAsenicals f sleeplag sicknus

ew

He duvelo ped

eDarsphunains in 1906 p yphilis

ar

dasificchon of fAntiicobial
bialdugs dhunmothuvapeutic agmts
C

Sulfpnamldus fintibtotiu
and reacd dkugs

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.Acc Cumical spucul

Sulfonamids e Sulfadiazl
QvinoloUs e. Norfoxacin, Cipaoftoxacin

. d aphalospoan

a
-loctam anHbiohiu Penicillin ,

,
Oxykhatydinu Doxycycliu

rm
Tetacyclin
Amnoglycosidus » Sbeptduyuin , Neomyin

Macolides » -€thvomyai, Azihrony

ha
Tup of Oqanicms aaius whlch Pimaudy Ohve

Antibacejal » Penicillin , Aincglycosidus

lP
Anifugd ariseofolvin, Anphojericdn R

Atniviral Atydovir,Zidovudin
Arhiprotozoal Coroquinl, Metvoldazolu
el

, Diekul
fintminie Mebundazou Caubamazins
ew

Spactum of actiuw
Norou sptrum eicillin, staptoyein, tybhromin
Brood spcum Tetvacuyclints, chloramphuni col
ar

Tup Achon

Bacleiostahic Sulfonamiduu, Tehaydlinis, cMorampkinl teols,

C

tnythroycln, dindoanuucin

Boceicdal Penidllind, Ainoglycosias , Poly pLphidus

ifanpin, Tsoiazid, úphalaspovins, ouoquinolonu,

Nutronidazoll CotvimoxazolL

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Conmmon
Adveul eftcs of Anti mooblal aguts

Toxic Can Caws& SAweul local + Susemic

toxic
6Hy pemswwiiilg Soveu Stin rashs alluugic ws.

a
Drug resistad Unes ponsive owavds dug
dugs

rm
Supra -insectim applananu of n Infechins

Nau sa Voniing, eht

Headacht
ODnnrerus

ha
hok Oh Sulfonamidus and Corimoxazol

Sulfonamida
v first anti microbial aqu
lP
which effechive againa Pyoqunlo bacteja
infechiows Producinq o producad ey feuen
el

In 192S, Gehad Domagk discovevt

t firsF
Svlfonamid - (prontosil) rvbrum.
ew

Usd p pat expei mantal speptococcal

ifectimy

Sulfonamidu may ba considued

ar

a deuvative of Sulfanilamidy)
(p-aminobLnzinL sulfonamidl).
SONhL
C

Sufonamidus ppymaaily boceuostatic

aqains Many qvam-positivt and gram-nugohive bocleia.

bnsa

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Classificatim

Sulfonamid»|

a
Shoar achu Long adiug| Sprcial
Ineudale pLLApos

rm
achiug) Sulfadoxlu
SulfadiazINt 2olu Sulfanmutho
Sulfauamidt
SvlfomthOxO
Pydzin .Sulfasolaziw.

ha
Mechanjsm (M04)
basically baceaostatie in nadwe (alona)
hey a
iniihing4 folic au
lP
which gives heir achion
4
whlch a Hsponsfels -for h Shui ot
Suntui
DNA RNA Ond ups in u qoWh OF backNa.
el

PADA + Glutamale + Pteridins

ew

l-folale yntha
Sul foramid
Oikydvofolic acid (DHF)
ar

felie
Dihydvofolote
Qcd
oPiMOXOZou reducta
C

(THF)
Tetraydofolic oud

1Groud oF DNA + RNA SYNth

bacfeua

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Pcokinhiu
- Rapidly and navly Complelely
absovbud fom gil.

Dtshi buhn (widuly also In csf plawma)

in live by nom-maosoma enzymu

Maboliim

a
exueHon by Cidnuy t2ld ks .

rm
Adves rtachions disconfork bulou)

NaUSLa, Vomufing Qnd epigasic paln.

ha
typnsunsi OtcUs in 2-S. patients..
Rashus

USL
lP
-Meningtis sulfadiaziu)
UTI (sulfamoxazou)
Malaia Buvns-Oculan nftchon
el

Cotvimoxa zOu|
ew

tha fixed dosa Combinahion Of

Iis
ang Sulfamuthoxazolu .
imutho pim
whith inhibis
ar

- Tri mthop>im is a antimalaaldaug

botey ial dihpvofolat reductase DHFRa

a
C

Individvally, both Sulfonamidds ond imthoprim

bacteriosfotic, bu In combination i gives

(bactericidal) achan
Sulfanutioxazolu + Tinuthopulm).

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| MOA PABA + Glutamalt + Pteidin

folalt sywtaLt

Sulfautmoxa2alt Dihydrofollk aid (DHe)

a
Dihudhofolai tedufast

rm
»
Tithopum Tehahydrofolic acid (THE)

Cotrmoxazolu) DNA RNA Synuy

ha
bacteicdol
ratio Sulpkanuthoxazolu: Timopim |SI|
9m
lP
we

Pcotinuhu
is mou rapidly absovbed than sulfamuhoxazol.
el

trimuthopum (uoy) SulfamathoXa2ol (6s7.) plasma

Paoletn bound.
ew

panHy muabolizd in live

excttd urin tV
ar

Adve eHeds
Vomujing tormatitis hadadt + ashush
-
Nausa,
C

folate duficloncy (galoblashic anmia).

Shovld not duing pugnanuy

b given

USU - Bacceal diarrkota typhad

- UTIs (Urinauy tpad nfechom) Repialoy pac infectiou

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wrie detailed noF on Antibiohic

Pencillin QUinolonua

mudiun
Cephalospourd (duai) Macolidu sho
Aminoglycosidus
febacydinu
ChJoramphunicols

a
rm
Artibiotics | thu thos chumothuapwtic
which Uud to lillk
inkibis h growth Of bockera Ond -y

ha
also obtaind Aom any typt Of micoorqaniom

Pencillin (obtainud fom funqvs) th

Iill
lP
staphylotoctws bockenia.

Histp Tn 1929, Sir Alexandr feming aciduntiy distovee4

el

firs antji biotic Pnicillin by dusoying t

Staphylococws in Cwltu plakt
ew

- fat of Chumotuapy Paul Ehvlich

Sbepto mudn by Selmon waks man 1492

ar

Culoram phnicol 194+

Chlartthacuclin 1q48
C

Neonyd'h 1944

ryth rony din 1952

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Clastificains

- fc. to thi Ochim

)Bacteiostahic inibik t gouwth of

eayclinns

a
bacheya. eg.

rm
) Bacceucidsl » ilk u bacteua eq. Penicillin

ACc to then SpActrum

1 Broad vange of actins

ha
spLchum wids
e.Teaayclins.-
) Narouw specum » shou vang of achon) -
lP

ANTIBIOTICS
el

PLS.REKERS
foR- RERERS STRT
ew

UNTT+(2 CHEMI
ar

UNTT
MEOICINAL

1-SE SEM
C

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