DRUG STUDY

NAME OF DRUG CLASSIFICATION INDICATIONS SIDE EFFECTS NURSING IMPLICATION

 Monitor mental alertness of the

DIPHENHYDRAMINE
Brand Names:
Allfen, Altarussin, Amibid LA
Antitussin, Bidex 400, Diabetic
Siltussin DAS-Na, Diabetic Tussin EX,
Drituss G, Guaifenex G, Guaifenex LA,
Mucinex, Robitussin
DOSAGE
50mg TID PRN
Pharmacotherapeutic: patient when taking
diphenhydramine.
Diphenhydramine is used to relieve red,
Histamine-1 antagonist, first Dry mouth, nose, and throat  Instruct patient that this drug may
irritated, itchy, watery eyes; sneezing;
generation. cause drowsiness or sedation,
and runny nose caused by hay fever, Drowsiness
dizziness, blurred vision, cognitive
allergies, or the common cold. It is also
used to relieve cough caused by minor Dizziness and psychomotor impairment, if
Clincial: throat or airway irritation; prevent and affected, do not drive or operate
treat motion sickness, and to treat Nausea machinery.
Antihistamine, anticholiner-  Instruct patient to take
insomnia; and is used to control Vomiting
gic, antipruritic, antitussive, abnormal movement problems. diphenhydramine at least 30
antiemetic, antidyskinetic. minutes before exposure to
situations that may cause motion
sickness.
 Advise patient to take drug with
MECHANISM OF ACTION CONTRAINDICATIONS ADVERSE EFFECT
food to minimize GI distress.
Drug tolerance  Advise patient to avoid taking other
OTC drugs that contain
Binds to central and peripheral H1 Stenosing peptic ulcer or Agranulocytosis diphenhydramine to prevent
receptors, competing with histamine for pyloroduodenal obstruction. Premature additive effects.
these sites and preventing it from infants and neonates. Lactation. Hypotension

Capsules: reaching its site of action. By blocking Concomitant use with other Thrombocytopenia
histamine, antihistamine-containing medicines
25 mg &50 mg (including topical antihistamines). Eczematous reactions
diphenhydramine produces
antihistamine effects, inhibiting GI,
respiratory, and vascular smooth-
Cream:
muscle contraction; decreasing capillary
1% & 2%. permeability, which

reduces flares, itching, and wheals; and

decreasing lacrimal and salivary gland
Elixir: secretions.
12.5 mg/5 mL Diphenhydramine produces
antidyskinetic effects, possibly by
inhibiting acetylcholine in the CNS. It
Injection Solution: also produces antitussive effects by
directly suppressing the cough center in
 50 mg/mL

Liquid:

12.5 mg/5 mL the medulla oblongata in the brain.

Syrup: Diphenhydramine’s antiemetic and
12.5 mg/5 mL antivertigo effects may be related to its
ability to bind to CNS muscarinic
receptors and depress vestibular
stimulation and labyrinthine function.
Tablets: Its sedative effects are related to its
25 mg & 50 mg CNS depressant

action.

Tablets, Chewable:

12.5 m