Cardio 1 - Isotope, CT, MRI

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CARDIOVASCULAR INVESTIGATIONS Ñ 461,1

1-PLAIN FILMS
2-ULTRASOUND 4 echo .

3-ISOTOPE SCANNING
4-CT
5-MRI
6-ANGIOGRAPHY

Hand mit Ringen (Hand with Rings): print of Wilhelm Röntgen's first "medical" X-ray,
of his wife's hand, taken on 22 December 1895 and presented to Ludwig Zehnder of
the Physik Institut, University of Freiburg, on 1 January 1896
☐ Krogh
X is the first I heart
* -

ray in cardio
modality imaging the .
& the
body in
general .

*
why X-ray ?

Ava liable
1-
widely .

2- Cost effective

3- give important into include

↳ size of heat ,
Chambers
,
calcification in valuer ,
stats ol the main vessels

stats the ( pkudeltusim hyperemia )


hrg lung congestion • . .
, , ,

(2) US

mainly used
echocardiography
* as

*
highly available

* But it
requires a psltessimd physician (
operator dependant )

#
Disadvantage #
*
not reproducible .

view
% NIG -511
Mo #
9)
'

-

ISOTOPE SCAN
cardiac
a imaging
② Bone for Metz Fracture
scarring &

meta
③ Thyroid &
Parathyroid

@ . . -
① ②
The radio pharma used radio (Iodine )
mc in
isotope scan is
Tegnisum ? * other pharma can be used is

"

common Precursor
"
ls I
'"
for
Thyroid function

|
É
- I

' "
it's I b
-
labeled ,
thyroid GÉT-heap;y

- Could be matched in other materials like

B-iphzsphon-k.fi#,DTIA,DMS-A , MAI ③ Gallium


-
-61 Hmos .- - I detect the
sovrcedirlla-orsited-T.mn
#
Selectivity I
Tegnisv - si 0€ A
matching 1 -
Cfl #

201

Iegnism & RBIs & .


matching µ .
Blessing c-÷ HI ④ Thalium
- r

& RBCs ÉO_tpI -


one I tie me used radio pharma .

& HMPAO Braini-n.org ing - used in cardiac


imaging .

Function I
& DTPA kidnap
f. DMSA Struuturedadney ⑤ Xenon

V-QSo-a~t-venl-iatim-pefsimscan-I.fr
& Diphosphonale Bone
imaging -
vied in
lung ventilation Function (
MAGS Renal
Imaging & Brai -
ISOTPE SCAN
• Rest isotope scan using thallium ( Ti201) injection.
• Dual-isotope imaging is a hybrid protocol that
combines a resting thallium injection and
subsequent scan with the injection of either
Tc-99m sestamibi or tetrofosmin during stress.
• Adenosine stress test if patient cant physically do
exercise (Pharmaceutical stress is used to increase
blood flow to the heart muscle) .
-

:
PETS.CI

Detector

Detects
(
2Dekcb-rsldif.lt
31-2%66
at ↳ II.

.
( Activity) si
CIEL I =-D

( SPECIF) É

S :
Single
P : Photon

E : Emission
C
: compiled
T :

Tomography

* Disadvantaged isotope : Doesn't give a cheer anatomical view .

# isotope is I known
an
imaging #


Concentration d Certain Radiophone

Excretion I
kidney

→ Uptake by tumor

PET / CT or PET / MRI ← €1 MJ or


pftsc-ns.gg *
→ a
function Function
Ana .

Anatomy
?⃝
20 '
→ Tha him

-
\
Tegnisum
201 999
Tnaliv - Us Tegnisv -

-
Produced in 70 's -
never

Has labels to substances


many
-

tf = 73 hrs -
ttz = 6 -7 his
-

Di
41,2 loveday _ñ

Better

imaging

* Usa & isotope in


myocardial pebsim ?
I -
Detect ischemia

2- Detect Abnormalities 1 Cardiac muscle .

from
Distinguish irlargtiom
3-
is¥a
decreased BI necrosis d muscles
-
Supply
-
-

4- Was the 1st method to evaluate the EF ( ejection Faction) ol the heart .
& Component &

the heat chambers .


seotimI(
Cross -

Sagittal

-
Time -

Stress 99mTc-tetrofosmin/rest 201Tl images in a patient with a low likelihood of CAD.


The first and third rows are stress short-axis slices from apex to base. The second and
fourth rows are matching rest slices. The fifth and sixth rows are the stress and rest
vertical-long-axis slices, while the seventh and eighth rows are the stress and rest
horizontal-long-axis slices.
is done Pest Stress Phases
* The
study in & . . .

It
-

.
more common

si I

RaIophama_ 4¥ # I

.Ñ ⇐ ,
,
I 41 &! ,

8) ↳ ↳
µ R-i-adoph.si 6-

¥-1m 4¥ & .
•is .

① scan alter 1 hr .

② scan alter 4 hrs .

emotion & heat material ( MASADA ) I. G


* To evaluate the the ,
the is injected I i
,
C

# ÉTe_t ) 1 ← i I #

# it! I - Function is → i. #

(
including f- f-
ejeÉ_n )
cross - sectional -
I
¥

-
o's ↳ 2

Radio
phorm

stress Jl &

6.61 I ↳↳

RI
supply "
&
-'j,
-

€4

# Area d Ischemia
É

Der is ~ 5 3

11
i.
Rest & Stress
- -

( inlaik-mn.at
DehIin
Defect in stress

b
= irreversible
ischemia

or
infarction
?⃝
Area I
-
decreased

Activity
-

→ ( ischemia )
vessel
- I 1501¥ It
gs . .
#I 6 * * To
image
the
coronary
- -
directly . . .

# for stenosis or occlusion #

C.C. 6¥ s, §
① Conventional
Angiography ÷ @i
① It's not operator dependant
" " "
"

an

Hii
-

② CT MRI -

⇐←
-


③ MRI
-

② Determine the
viability l the muscles

(indirect indicator I vessels status )


-
coronary

ZÉg A ,
- Ischemia
-
11--66

Infarction si -66 IN
-

# ¥-020

*
ischemic pt _
Angioplasty or
stenting
infarction be done
* _
Nothing can

ischemia n' ↳ 61
µ Iwi in H
Coronary CT
↳ need

↳ for low → intermediate risk pt .

¥ a
:b Kid % *

→ wasted time
- # 516 EH J.su %
, .

↳ Cath lab combined


management ( Cath Lab ) o
invasive

¥6 I 36
or medical mangmet .
, to Its

31 I ¥ ,

↳ general idea if there's

vess-dsi.se gÑ ,
'
# b- disecm ,

cdM thrombosis I
annoy ar
.
What is needed?
• Good CT scanner ( 64 detector or more). specif
detector Ñ ¥31 % I
¢4 si

= ( ) ← .

• Patient cooperation. To be
developed able to catch his breath
,
but the CT devices can pick the
image
← anti during one heart beat

• Stable heart rate , heart rate around 60p/m.


.

IF Mi is & 8,5

I
% 's ↳ a-
%
F-

• Regular CT Contrast injection ( iodin) at high rate . -

• ECG gating. →
& ECS
g. .
si
c
6m11sec
'

# if!
5-
=
.

350 ( concentration )
HE sins ↳ of Reconstruction at 75% 30% I ECG
=

cycle
or

&
=
=
- .

Ii -568 ji I ¥ -
= R R -

Cycle
Is, # I

¥ :& .Ñ!b
'

Ii y Ñ
.
_

.
%.
stable is

¥
'
.
&
-
8D , I 2£ -

B - Blockers

KYI . -

if i _
¥1s
Cardiac Ct assess:
• Coronary vessels.
myocardium µ -
ji ,

) ( congenital Anomaly Stenosis occlusion


, , ,
bridging
-
.
.
. .

• Aorta . ( Direction , Dilation )

Aneurysm +

• Functional ( thrombus , EF , contractility,….) →


Ref CT isn't operator
-
dependant
-

• Muscles viability ( dual source/spectra CT).


( calcification →
thickening )
• Valve ,

i s o b j - I . s i # b J ? - ' w i s j - . o s i s l a c te d - C I M
.
⇐ ↳ *✗ as % , *

viability & Conte si -6

Coronary 11 -6 ↳ 6. •

Aorta
Values

d-i-s-b-ib.si 66s

. -4¥ v81 too


Usage , limitation :
to
• Mainly used for low- intermediate risk patients . Advantages
ji
'
C.

• Not indicated for high risk paints except in some


advanced centers.
• In case of heavy coronary vessels calcification , it
has low resolution. even in LL
-
smdlvebeh-
angio
,
CT
-
→ no clear
image
s'
due to the

& ji evaluation
dense

1 %
calcifications espec

¥6 & digest g-
.
in

6 &
Big

• high heart rate , Arrhythmia and irregular heart


limitation it's #

-j # I
,
,
calcification → white

% 4-

91 id
%
-
rate is limitation for some type of CT scanners. "
CT Contrast

s #
→ white

IN

'

• Used to assess complex cardiac congenital


( MRI )

.GS#d-w-fMt--2Jai
d

detects the lbw

anomaly. ↓ ¥ I Esto
µ si •
caeia
¥

ii. i
¥


#

( RÉb_ ) & ( %) €01 '


Is It 15 shot +
TJ Calcification § :-D ( Ca score )

#
,
si I 48 CI A ← as
-

[ Pca ]
Ca score score -
F Risko

Grozny
Risk si mi a
Ñ , Greg AJ d c

Ar.dz/
• Used for risk stratification for coronary , valve and
aortic calcification.
• low , intermediate risk patients. 111
• Not used in case of previous bypass surgery or
coronary stenting. distinguished soitwoÉbeacwa_e


due to
surgical
d
clips that

the
can't be from Ca
"

by
CT ( )
No value measuring Catt score for a Pt that has stent or had
bypass surgery

• With /without ECG gating , but not affected by


.

>
-
b ,
along
( Risk Pt )
High ⇐

limo
NEWT ↳ 61

heart rate and arrhythmia.


,

low & intermediate

, Is Choi e i → st@oq_Io-sa1I.ssv_w1s-isls_81i868fC_TH.r3.s CAST 111 /←



conw-ast.IO I * i.
ECG
Gating -8¥ ↳
&
É

evaluation I stenosis µ CI 1 8,5 -


m?
Coronary veiuh 1 & Fiji Fca -1+1 % 61

-
regbr HR is important .
-
-

Calcification in vessels -
to resolution ICT Jl 4

# II ET si - É 6

ECG
Gating
_qÉ %Y -
( ( µ ;) B- Blow
, do
dependant )
"
* Results I Ca Score -

very
accurate ( not operator - no need lsr contrast
- - - - - .

however essential
NI swe indicates the status I kept in relation to
Choisy ,
cardiogram is

I. Gish ,
, ,
>
p * •

imaging si si AI is
C
=
=

✓ Ii t.ms is
i. ↳ score #
*

CCa1aihidi_on_IIFs-i-vezdofw.i4t-x.e@1oJ.w.I
I 6
if! Catalog & → g- III *
The result of the test is usually given as a number called an
Agatston score. The score reflects the total area of calcium
6 deposits and the density of the calcium. -
II
CaScore- RiskdC_AD

Éj
Ega
&

clinical 0 low
+
very
↑ Frisk & dz assessment
score → coronary or .

100 -
300 intermediate

> 300 further evaluation )


high risk ( need

• A score of zero means no calcium is seen in the heart. It 11

Plug
It

in one
JG #

major vessel

suggests a low chance of developing a heart attack in the


- - -
-

+ Ca Score 100

↳ risk
high
future. Sl
- -

Iss
-

• When calcium is present, the higher the score, the higher Pluge 8- c- is

your risk of heart disease. vessels

~É 8)

• A score of 100 to 300 means moderate plaque deposits. It's


ji

associated with a relatively high risk of heart attack or other Rigidgot ↳

heart disease over the next three to five years. Cardiac


-
- ;D

consultation
-

• A score greater than 300 is a sign of very high to severe


f-
disease and heart attack risk.
Ki Isi ⇐,

£1

I
earlier detection

CAD Risk can

be done by
iliac vessels

& lemond vessels

Ca score
-

w.IN
" '
f. *
( evaluation)

atherosclerosis t.IE
"-
← Ii
Gguessed

soon number d
> 300 =
high risk I CAD volume or
plugs .
0
-
hi
calcification 24

¥
According to the American College of Cardiology and the American Heart
Association guidelines, a heart scan may not be recommended for the
-

following people: = Ca Score isneeded


not in . - .

• Men under age 40 and women under age 50, because it's
unlikely calcium can be detected at younger ages or
they may
di section
have thrombotic

detection I
de .


_ 61

• People who have a very low risk, because detectable µ •


u
⇐ " ↳

calcium is highly unlikely if you don't have a family history of


heart attacks at an early age asymptomatic
&

#
• People who already have a known high risk (especially • it ↳ ↳

heavy smokers or those with diabetes or very high high Pt very


- - -
risk
- -

cholesterol), because the heart scan will likely not provide 8=615 -

any additional information to guide treatment ( GSI ) g

• People with symptoms or a diagnosis of coronary artery pl -12*1 '&


- dol

is
,
I

disease, because the procedure won't help doctors better


understand the disease progression or risk
• People who already had an abnormal coronary calcium
heart scan £
-

⇐ is c. 2=16 g- GSuo_e y
Gross

ascending -
aorta
↳ mon .

if .
# 1 Ar .

1=-1 3-
'
11
trigger ←

L
Asf Aorta D

* ÷ it! ,

"
BIG fist
D Contrast

( AI )
# Reconstructive reconstruction at 756 I RR
imager .

ECG

Gating

=
=

u
"
reformation
"

# MPR images multi


plane ,
"
or multi
planar reconstruction
12¥

g
VR ( rendered I
*
-
image -
volume
-
-

Abnoim-d.ly § i. ljl
l
Cnoa-bnomah )

9-

#
V# # maximum intensity projection # %
severe stenosis
" """
# MPR #
°

severe stenosis near occlusion due

(
& " " " "" " "
" """ "

"
* calcification #

narrowing
Proximal to

p.IS#(slent-t
MYOCRDAIL ENHANCEMENT AND VIABILITY ASSESSMENT

myocardial enhancement

① -
severe stenosis
in Lt main

trunk at the
severe
bifurcation I
stenosis
LAI
in LAD

Q
o
0
t.mn#us1&..-i-iwIoG
twos
① BBI
Supply = infection
= to B1
supply =
infarction ③ thin myocardium due to previous
myocardial
- - - - viability
-

LV
-
Apex
-
} IT thin
papillary muscles

]
- -
-

enhancement
- -
"

deb
Gray area ( b enhancement )
] thi-nmpgwd.im
b
→ ← £
( muscles É é-w, )
of ( cross-sections )
11 - -1
.
#
wrong vessels calcification
stenosis
& . . .

# Functional evaluation

-
color-coded

conventional
angiography
-

¥ ( stenosis )
Cardiac CT functional assessment
By
-
.
CT
-

3D d chambers
* image
software
end diastole & end systole
É

CM
images -

TT sensitivity & specificity


Is H ÷ - - - - -
-
-
,
.

"

l ejection traction ) not


-
operator dependant •

- .
-

* muscle
- contractility
- -

MRI
v1 11 at
- 6 #

-6,1b€
. . .

⇐ t.mil V41 £6 It it 6 #

Cardiac CT Cunctind Assess


9.1 -
- - - -
-
-

t.MY?EIgYneh--- ⇐ •

Functional
- -
Analysis
- .
11
By
G-
LV apex thrombus

0
Q
(enh_ance_mt--
detect
Filling 5T¥ I
= b enhancement ( td-sit-sth-n-mus-e.tn " "
easily detected by Cardiac CT
- -
- -
-
- -

q
Myxoma LT atrium ( most common location)
filling defect in
LA= near to the als_eptI & some calcification * took some enhancement
-
-

(mainly r )

0
① Cardiac Isotope
BE ① Cardiac CT

Cardiac MRI. ① Cardiac MRI

• Patient cooperation ( long study). very expensive+ study


• ECG & respiratory gating . some
requires
sequencer
in MRI Breath hold
-
↳ Is ,
-

• Specialized technician and physician( skill


demanding).
&? stat , Gim # ÷ induction
fibrosis
MRI detect

Cardiac MRI used for: #


-

to Éi # \ Amyloidosis

Deposition dz .
in the muscles

isotope ←É ÷
-

✗ " "" " µ


isotope is
-

SI
contrast
↑ viability i I
go.im ' - ↑

Mdg
-
MRI 777 CT D) CI
MRI

• Muscle viability , masses, thrombus , contractility .


,

• Functional assessment . (contractility )


• Used to assess complex cardiac congenital
anomaly.
\
CT can be used also
54 G. .-

• Coronary vessels. MRI 77 > CT


- - -

{ MRI 11 •

÷
\ :*
standard Cath lab relation to the
# The gold is
-
major vessels

then
CI septa .

Ii ¥
-6
M¥ '' .

@I g-
" c-

i.
÷ ,
Gladiator
# MRI
-
→ m .

Contrast
viability
is not
needs

required
MRI

in
contrast ( like G)

functional studies

schematic

diagram

cardiac
imaging .

-
muscle
this
car .
-81
&
,

%
it ,

"' a.
|
* " "" & ↳
" "
-
" - -

F ischemia
-
←↳
Another Application be
MRI is
ftp.gafial-lla-ss in
Hypertrophic Ip Paff ←
-

MRI
.

32.244

oil:& :*
if

Debut 1 muscles
king
by sight

31 #

- ma±
t n %.MIL .

i. Ñ
n si - .wj -

re
level in cross

section
# Cardiac MRI *
Contrast
- -

-
LV
Apex

#
thinning & muscles endocardial
b
-
-

enhancement
a - -

mu JI Is
I
part
-

/ & upper
Ms & ' -6
muscle is
.

the

muscle si §!
while now
] 1- ←

due to
÷÷ ↳ MI

① thinning
① ¥
# Time Interval Images
- -

Acvk Phan

=÷,
-
C wit
o

*
Thinning
i
status I
myocardium

*
Enhancement
=

Late gadolinium imaging in horizontal image plane at 1 week (A) and 4 months (B) after
the acute event. At 1 week, presence of diffuse enhancement of the apical part of the
ventricular septum and LV apex (arrowheads, A) with large area of microvascular
obstruction (small arrows, A). Note the presence of some pericardial enhancement over
the laterobasal part of the LV (arrows, A). At 4 month follow-up, the infarct has thinned
and strongly enhances (arrowheads, B). Note the presence of a small mural thrombus in
LV apex (arrows, B)
"" " "" " "
"

Contrast is in
req -

LV ventricle apex thrombus



CI " - '
I

Thrombus in Apex

g( 0

MRI

Gets
?⃝
contrast in CT
Myxoma at RT atrium bulging inside the RT ventricle.

my na

*
.

the valve
]

Filling feted

sign 1-
Mush JI
@
in IT & -12 &

other MRI sequencer

is #↳
# im
-

Io #

→ 81 t.SI
other applications lo , MRI
=

dz
±yn◦&
deposition muscle
in -

→ muscle
dystrophy

ibge functional Assessment


. . .

€r←ñ: £
( time- -
Consvmi
- -3
' 8ps, _Él *

l cost )
high
- - -

C-
¥ ¥ 5- ski
'

"
& I →
1 I
emotional
#
Analysis #

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