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Sepsis 2021 Completeppt
Sepsis 2021 Completeppt
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2012 3rd
4th 2016
2021 5th
Recommendations
Lower-
High-resource
resource
settings
settings
Definition of sepsis
Six SSC adult guidelines working groups:
Damiani E, Donati A, Serafini G, Rinaldi L, Adrario E, Pelaia P, Busani S, Girardis M. Effect of performance improvement
programs on compliance with sepsis bundles and mortality: a systematic review and meta-analysis of observational studies.
PloS one. 2015 May 6;10(5):e0125827
Screening and Goals of care and
Additional
initial Infection Hemodynamics Ventilation long-term
therapies
resuscitation outcomes
21 14 12 16 20
?
Screening and Goals of care and
Additional
initial Infection Hemodynamics Ventilation long-term
therapies
resuscitation outcomes
12 16 20
21 14
?
AUROC
Machine
0.89
learning
SIRS 0.7
MEWS 0.5
SOFA 0.78
Resuscitation
16
14
ICU
Admission
21 14 12 16
Screening and Goals of care and
Additional
initial Infection Hemodynamics Ventilation
therapies
long-term
resuscitation outcomes
Screening and Goals of care and
Additional
initial Infection Hemodynamics Ventilation
therapies
long-term
resuscitation outcomes
Infection
Screening and Goals of care and
Additional
initial Infection Hemodynamics Ventilation
therapies
long-term
resuscitation outcomes
Screening and Goals of care and
Additional
initial Infection Hemodynamics Ventilation long-term
therapies
resuscitation outcomes
Screening and Goals of care and
Additional
initial Infection Hemodynamics Ventilation long-term
therapies
resuscitation outcomes
Screening and Goals of care and
Additional
initial Infection Hemodynamics Ventilation long-term
therapies
resuscitation outcomes
?14
HFNC vs NIV
Screening and Goals of care and
Additional
initial Infection Hemodynamics Ventilation long-term
therapies
resuscitation outcomes
?14
Low tidal volume ventilation
strategy with limitation of
plateau pressure
Prone positioning
?14 16
Screening and Goals of care and
Additional
initial Infection Hemodynamics Ventilation long-term
therapies
resuscitation outcomes
14 16
Blood purification??
Screening and
initial Infection Hemodynamics Ventilation
Additional
Goals of care and
long-term
therapies
resuscitation outcomes
Ulcer &Infection
Screening and
initial
thrombusHemodynamics Ventilation
Additional
Goals of care and
long-term
therapies
resuscitation outcomes
Screening and
initial
AKIInfection
& RRT Hemodynamics Ventilation
Additional
Goals of care and
long-term
therapies
resuscitation outcomes
Screening and
initial
Glucose
Infection Hemodynamics Ventilation
Additional
Goals of care and
long-term
therapies
resuscitation outcomes
Screening and
initial
NaHCO
Infection 3 Hemodynamics Ventilation
Additional
Goals of care and
long-term
therapies
resuscitation outcomes
Screening and
initial
EN
Infection Hemodynamics Ventilation
Additional
Goals of care and
long-term
therapies
resuscitation outcomes
Less
14
emphasis
Sepsis
Education
?14
ICU
Handover
?14
ICU
Discharge
?14
?14
ICU
Follow-up
?14
Conclusion
• Very few strong recommendations
• More areas of research identified.
• Applicable even in low resource settings
• Focus on post ICU discharge planning and long term oputcome
• They believe that the 2021 SSC guidelines will foster the delivery of
best practices for sepsis evaluation and management, as well as
highlight aspects of management where additional evidence is
needed most urgently.
Thank you