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Parathyroid Hormone
Parathyroid Hormone
Parathyroid Hormone
The parathyroid gland contains mainly chief cells and a small to moderate number of oxyphil cells. The
chief cells are believed to secrete most, if not all, of the PTH. The function of the oxyphil cells is not
certain, but they are believed to be modified or depleted chief cells that no longer secrete hormone.
the chief cells (zymogenic) are basophilic cells that are located in the bottom of the gland and which
produce different gastric enzyme precursors, such as pepsinogen.
The secretion of parathyroid hormone (PTH) is regulated by the interaction of the calcium-sensing
receptor with calcium in the blood. The calcium-sensing receptor is present on the plasma membrane
of the chief cells. The CaR is a G protein-coupled receptor, as part of the C family.