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Process Preparation of Polypeptide 1-6
Process Preparation of Polypeptide 1-6
Process Preparation of Polypeptide 1-6
9 10
step against water until the average molecular weight stirred at 80°C. under nitrogen for 4 hours. The reaction was
reaches the required value (Scheme 6). filtered through celite and the cake was washed with 4 mL
of hot acetic acid. After evaporation of the filtrate with 32
mL toluene, a beige solid was obtained (polypeptide 1, 1.4
Scheme 6
g, 70%). The material obtained was dissolved in 28 ml of
crude polypeptide 1 water, filtered through 2 g of celite and the clear solution was
(as an acetate salt) dialyzed against water in a dialysis bag for 24 h. Upon
completion of the dialysis, the solution from the bag was
pass against water 10
evaporated to dryness by co-evaporation with toluene to
yield polypeptide 1 as an off white solid.
Polypeptide 1 EXAMPLE 4
(including Glatiramer Acetate)