1. As per US FDA, Fosfomycin is pregnancy category ____ drug.

(4 marks)

2. Why single dose of Fosfomycin is highly effective in the treatment of

acute uncomplicated lower UTI? (5 marks)

3. Dose of Evafos granules is _______, __________ for oral administration.

(2.5 marks each)

4. Each 8 gm sachet of Evafos granules contains 5.631 g of __________

which is equivalent to _______ gm of Fosfomycin. (3 marks each)

5. Evafos granules can be used safely and effectively in a 10 year old

female child. (4 marks)
a. True
b. False

6. Why Evafos granules is preferred to be taken at bed time? (5 marks)

7. Briefly note on comparison of Fosfomycin and nitrofurantoin use during

pregnancy. (6 marks)

8. Briefly explain the mechanism of action of Fosfomycin. (6 marks)

9. __________ is the most common uropathogen causing UTI. (4 marks)

10. Single dose ___ gm Fosfomycin leads to urinary concentration above

____ mcg/ml for 24-48 hours which is sufficient to kill most of
uropathogens. (3 marks each)

11. Enumerate reasons for low resistance to Fosfomycin. (5 marks)

12. How Fosfomycin is superior to other antibiotics in the treatment of acute

uncomplicated lower UTI? (6 marks)

13. Fosfomycin trometamol acts as an antibacterial drug in a specific and

selective way. (4 marks)
a. True
b. False

14. Name the bodies recommending Fosfomycin as a first line therapy in the
management of acute uncomplicated lower UTI. (4 marks)
15. Why Fosfomycin is an empirical therapy for the management of acute
uncomplicated lower UTI? (6 marks)

16. Fosfomycin is not at all safe for use in lactating mothers. (4 marks)
a. True
b. False

17. Fluoroquinolones and co-trimoxazole are as safe as Fosfomycin in

pregnancy for the management of acute uncomplicated lower UTI. (4
marks)
a. True
b. False

18. E.coli causes majority of UTI because: (4 marks)

a. E.coli gets transferred from anal region to urethral region
b. E.coli has the ability to adhere to the urinary epithelium with its fimbriae
c. E.coli forms a biofilm on bladder surface which increases its adhesiveness
d. Only a and b are correct
e. All are correct

19. As per the studies data, maximum urinary concentration at 4 hours

achieved after a single dose is approximately: (4 marks)
a. 100 mg/l
b. 526 mg/l
c. 1000 mg/l
d. 4000 mg/l

20. Which of the following statement is TRUE about the mechanism of

action of Evafos? (4 marks)
a. Blocks the synthesis of bacterial cell wall
b. Increases the ability of microorganism to adhere to uroepithelium
c. Both are correct
d. None of the above

21. Evafos should be taken preferably on empty stomach at any time of the
day and by female of any age group. (4 marks)
a. True
b. False
 Details of Allocation of Evaluator
Evaluators & Hidoctor id Regions
1.       Faridabad
2.       Jalandhar
Mr. Sanjay Arora 3.       Bareilly
sanjaytr008 4.       Raipur
5.       Bhubaneswar
6.       Nagpur
  Regions
1.       Chennai
2.       Madurai
Mr. Ganesh Sai Ram 3.       Cochin
sairamtr005 4.       Jaipur
5.       Bhopal
6.       Ahmedabad
  Regions
1.       Hyderabad
2.       Bangalore
Ms. Sabitha 3.       Vijayawada
sabithatr006 4.       Mumbai
5.       Thane
6.       Pune
  Regions
1.       Kolkata
2.       Burdwan
Ms. Peuli Saha 3.       Guwahati
sahatr007 4.       Lucknow
5.       Varanasi
6.       Patna
  Regions
1.       Delhi
Ms. Vipra
2.       Ghaziabad
vipratr001
3.       Agra