RUAHA CATHOLIC UNIVERSITY

P.O BOX 774, IRINGA, TANZANIA

INSTITUTE OF ALLIED HEALTH SCIENCES (I.A.H.S)

SCHOOL OF PHARMACY

DIPLOMA AND CERTIFICATE IN PHARMACEUTICAL SCIENCES (DPS AND CPS)

PHARMACEUTICAL INORGANIC CHEMISTRY (PST04210)

CONTINUOUS ASSESMENT TEST I (DPS I AND CPS I)

Time: 90 MINUTES

FRIDAY 18th MAY, 2018.

INSTRUCTIONS

1. This examination consist FIVE sections A, B, C, D and E

2. Answer all questions and follow the instructions provided to each section
3. Unauthorized materials and cellular phones are not allowed in the examination room.
4. Write your name and examination number on every page of your answer sheets

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 SECTION A. (10 Marks)
Multiple choice questions
Answer all questions (each 1 mark)
1. Alkali metals
a) Are found as free elements
b) Not most reactive elements
c) They are shiny
d) They do not lose their shiny appearance even when exposed to air.

2. Oxides of group one element

a) Lithium forms lithium super oxide.
b) Potassium, rubidium, and caesium also form super oxides
c) The other alkali metals all form peroxides only.
d) Hydrogen burns in air to give water as gas.

3. Alkali earth metal

a) They are found un-combined in nature.
b) Melt at extremely low temperatures.
c) Ionization energy decrease across the period.
d) Have the tendency to form M2+ ions.

4. Use of alkali earth metals

a) Magnesium and strontium are also very crucial for the normal function of the heart.
b) Some used as replenishes
c) Magnesium does not used as antacid since it is highly soluble in water.
d) Barium hydroxide is applied in treatment operations.

5. Transition elements
a) Elements in the B families and some A families.
b) Are found uncombined with other elements in ores.
c) They are good conductors of heat and electricity
d) Have single oxidation states.

6. One of the followings is the physical characteristics of boron family element.

a) Atoms in this family have 2 valence electrons
b) all are metalloid except boron
c) Aluminum is the most abundant metal in the earth’s crust
d) Larger Group 3 elements exhibit multiple oxidation states

7. The use of group 3 elements

a) Most of them are used to prepare external preparations
b) Aluminium cannot be used to prepare antacids.
c) Some used to prepare replenishes
d) Some used as radioactive for diagnostic procedures

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8. Chemical characteristics of group 4
a) The metallic elements tin and lead react with water to give hydrogen.
b) The elements are also reduced by O2
c) For carbon and silicon, the +4 oxidation state is the more stable one
d) In lead compounds, the +1 oxidation state is the more stable.

9. About nitrogen
a) The nitrogen family is named after the element that makes up 78% of our atmosphere
b) Is not the member of group 5 A
c) It is a metalloid.
d) Have no valence

10. About phosphorus

a) Phosphorus is a metal
b) The element phosphorus comes in two forms—white and red
c) Phosphorus exists most commonly as tetrahedral P5 molecules
d) Red phosphorus burst into flames when exposed to oxygen in the air

SECTION B: MULTIPLE TRUE/FALSE QUESTIONS (20 MARKS).

1. The followings are true about hydrogen
a) Hydrogen is placed in this group one totally as it shares some features.
b) Like the alkali metals, it has a single s valence electron and forms a uninegative ion,
which is hydrated in solution
c) Also forms the hydride ion (H2) in ionic compounds such as NaH and CaH2.
d) Exist as diatomic molecule
e) It has only one isotope called hydrogen

2. About group one element

a) Sodium compound are being used to prepare disinfectants example sodium
hypochlorite.
b) One of the member produce normal saline infusion
c) Sodium is a radioactive element found in this group.
d) Metallic character decreases as you go down the group.
e) Exist as diatomic molecule.

3. The followings are not true about chemical properties of group two element
a) Most of the elements reduce H to form ionic hydrides
b) The alkali earth metals reduce O to form oxides
c) Beryllium and magnesium form oxides (BeO and MgO) only at elevated temperatures
d) Magnesium reacts with water in aqueous solution, liberating hydrogen gas.
e) Beryllium does not react with water

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4. The followings are chemical characteristics of transition elements
a) Titanium forms three oxides (TiO, Ti2O3, and TiO2) and corresponding binary salts
b) The soluble salts of divalent and trivalent titanium are violet or red and are powerful
reducing agents
c) Aqueous solutions of iron (III) salts hydrolyze strongly to give acid solutions
d) Iron (III) salts undergo slight hydrolysis and are oxidized easily in solution
e) Transition metals have a distinct tendency to form complex ions

5. The followings are true about chemical properties of group 3 elements

a) They react sluggishly, with water
b) When strongly heated in pure O, all members form oxides
c) Some of members reduce halogens
d) Boron does not form binary ionic compounds and is uncreative toward oxygen gas and
water.
e) Aluminium that has a protective coating of aluminium oxide is less reactive than
elemental aluminium

6. The followings are true about carbon

a) Is a non metal
b) Is a heaviest element
c) Can caternate
d) Can be found in human being
e) It is insoluble in body fluids

7. About group four element

a) One of the component used to prepare activated charcoal
b) Some used as ant acids
c) Talc is a dusting powder
d) Simethicone USP, a polymeric dimethylsiloxane, is used as an antiflatulent.
e) Stannous fluoride (tin (II) fluoride) is applied topically as a dental prophylactic

8. The use of group five elements

a) A complex basic calcium phosphate constitutes the main organic component of bones
and teeth
b) Phosphate has important roles in the metabolism of various inorganic materials, such
as carbohydrates
c) Nitrogen (I) Oxide (nitrous oxide) USP, is used as an inhalatory general anesthetic.
d) Sodium Nitrite USP is used as an antidote to cyanide poisoning
e) The radioactive isotope, 32P, is employed therapeutically

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SECTION C. MATCHING QUESTIONS (10MARKS)
INSTRACTIONS
This section consists of two parts, PART A and PART B, each part carries 5 marks
Match the response in column B with the most appropriate item in column A.
Each item in column A matches best with only one response from column B.
PART I (5 MARKS)

COLUMN A
1. Pharmaceutical organic chemistry
2. Pharmaceutical inorganic chemistry
3. Analytical chemistry
4. Physical pharmaceutical chemistry
5. Biochemistry
COLUMN B
A. Identifies, evaluate and compare
components of matter
B. Study of substances containing
elements.
C. Study of the chemistry of living
organisms
D. Study of all substances containing
carbon
E. Study of physics of elements.
F. Study of all elements
G. Study of theories and experiments that
describe the behavior of chemicals and
energy involved

PART II (5 MARKS)

COLUMN A COLUMN B
1. Activation energy A. Negatively charged ion
2. Anion B. 99
Tc
3. Ionic bond C. Positively charged ion
4. Hydrophobic D. Water loving
5. Radioactive element E. The bond between ions due to their
opposite electrical charges
F. Water hating
G. The minimum energy required to start a
chemical reaction

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 SECTION D: 40 MARKS, SHORT ANSWER QUESTIONS.
Answer all questions.
1. Briefly explain on the followings.( 8marks)
a) Principal Quantum Number
b) Azimuthal quantum number
c) Magnetic quantum number
d) Spin quantum number

2. Mention and describe the rules of filling electrons in the orbital.( 10 marks)

3. Write the electronic configurations of the following elements. (10)

a) Aluminium (Al)
b) Sodium (Na)
c) Strontium (Sr) ( use noble gas)
d) Chromium (Cr) ( use noble gas)
e) Zinc (Zn) (use noble gas).

4. Explain the physical trend of the periodic table on the followings (10 marks)
a) Core Charge
b) Atomic radius or size
c) Ionisation Energy
d) Electro negativity
e) Metallic character

5. Basing on the chemical trend of the periodic table explain the properties of oxides of
followings with examples.(12 marks)
a) Metallic oxides
b) Oxides of non-metals
c) Metalloids oxides

SECTION E: ESSAY QUESTIONS (20 MARKS)

Answer all questions, each carries 10 marks.
1. Briefly explain the importance of inorganic chemistry in pharmacy. (10 marks)
2. Describe the Dalton atomic theory and its short comings. (10 marks)