Professional Documents
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Vision
Vision
Dr.MINI.K
PROFESSOR&HEAD
DEPT OF PHYSIOLOGY
GMC MANGERY
FUNCTIONAL ANATOMY
ORBIT
EXTRAOCULAR MUSCLES
CONJUNCTIVA
LACRIMAL GLAND----TEARS
The bony orbits are quadrangular
ORBIT
EYEBALLS EACH BEING SUSPENDED
FASCIAL SHEATHS IN A
b)Ciliary body
c)Choroid
Iris :Iris is a coloured ,circular diaphragm
functions.
Anterior chamber
Posterior Chamber
Anterior and posterior chambers
communicate through PUPIL.
Anterior and posterior chambers contain
Aqueous humour
INTERIOR OF EYEBALL
Lens is a transparent ,biconvex,
crystalline structure placed between the
Iris and vitreous.
It is suspended from the ciliary body by
the suspensory ligaments or Zonules of
ZINN.
It is avascular structure and derives its
nutrition from Aqueous humour.
Refractive power –15----16D
CRYSTALLINE LENS
It is an inert transparent jelly like
mucoproteins
VITREOUS HUMOUR
The two eyebrows are arched structures
Extraocular muscles
Appendages and orbit
EYELIDS are mobile tissue curtains
LACRIMAL APARATUS
It is the main prerequisite for visual
Are;TEAR FILM,CORNEA,AQUOUS
HUMOUR,CRYSTALLINE LENS and
VITREOUS HUMOUR
Maintanance of clear
refractive media of the eye
It is the fluid covering the cornea and
conjunctiva.Tears are composed of 98%
water and 1.5% sodium chloride,
Antibacterial substances like lysozym,
betalysin and lactoferrin.
The pericorneal tear film consist of
3LAYERS
Mucous layer
Aquous layer
Lipid layer
1.TEAR FILM
FUNCTIONS OF TEAR FILM
Keep the cornea and conjenctiva moist
It provides oxygen to the corneal
epithelium
It washes away debris and noxious
irritants
It prevents infection due to presence of
antebacterial substances.
It facilitates movements of the lids over
the globe
Cornea forms the main refracting medium
2.CORNEA
LAYERS OF CORNEA
Epithelium-Stratified squamous
Bowman’s membrane
Stroma(substantia propria)-It forms the
90% of corneal thickness.Collagen fibrils
arranged in lamellae embedded in ground
substance.It consists of ACID
MUCOPOLYSACCHARIDES,CHONDROITIN
SULPHATE,KERATIN SULPHATE,In between
the lamellae keratocytes,
wandering leucocytes and macrophages
are scattered.
Descemets membrane-Secreted by
endothelium and forms the basement
membrane.
AQUEOUS HUMOUR
Constituents of Normal aqueous humour
Water—99%
Proteins---0.04%
Na+,K+,Cl-,Glucose,Lactic acid,
Aminoacids,Inocitol
Rate of production---2.3ml/mt
Mechanism---Diffusion,Ultrafiltration and
secretion(active transport)
Ultrafiltration-The filtrate accumulates
behind the non-pigment epithelium of
ciliary process
Secretion-Tight junctions between cells of
pigment epithelium creates blood aqueous
barrier.Active transport occures by Na+K+
ATPase pump and Carbonic anhydrase
enzyme system.
Diffusion is responsible for movement of
water into posterior chamber by osmotic
effect
DIURNAL VARIATION
VASOPRESSIN& AND ADYNYL CYCLASE
HAVE A ROLE IN ACTIVE TRANSPORT
OF Sodium
BPin Ciliary capillaries
Plasma osmotic pressure
LEVEL OF INTRAOCULAR PRESSURE
DRAINAGE OF AQUEOUS
HUMOUR
90 % of total aqueous drained out via
this route.
Aqueous outflow system includes the
episcleral veins.
Trabecular outflow
1.Trabecular meshwork----It is a seive-
likestructure through which aqueoushumour
leaves the eye.It consists of three portions.
Uveal meshwork
Juxtacanalicular meshwork
2.Canal of Schlemm—This is an endothelial
lined oval channel present
circumferentially in the scleral sulcus.The
Endothelial cells of its inner wall are
irregular spindle-shaped and contain giant
vacuoles.The outer wall of the canal is
lined by smooth flat cells and contains the
openings of collector channels.
Free flow of aqueous occurs from trabecular
meshwork up to inner wall of SCHLEM’S
canal which appears to provide some
resistance to outflow.
Vacuolation theory—It is the most
accepted view.According to it transcellular
spaces exist in the endothelial cells
forming inner wall of Schlemm’s
canal.These open as a system of
VACUOLES and pores,prymarily in
response to pressure and transport the
aqueous from juxtacanalicular connective
tissue to Schlemm’s canal.
Mechanism of aqueous
transport across inner wall of
Schlemm’canal
3.Collector channels—These, also called
in to two systems
The larger vessels(aqueous veins) run a
2.Uveoscleral outflow
The IOP refers to the pressure excerted
by intraocular fluids on the coats of the
eyeball.
Normal value---10 to21 mm Hg
Normal level of IOP maintained by
equilibrium between the formation and
outflow of the aqueous humour.
Maintanance of intraocular
pressure
FACTORS INFLUENCING IOP
1.Rate of aqueous formation
2.Resistance to aqueous outflow
3.Increased episcleral venous pressure
4.Dilatation of pupil
5.General Factors like-----Heridity
Age,sex,diurnal variation,Postural
variation,Blood pressure,Osmotic pressure
of blood and general anaesthetics
GLAUCOMA-IOP is raised resulting in a
CRYSTALLINE LENS
Avascularity
Tightly packed nature of lens cells
Arrangement of lensprotein
Semipermeable character of lens capsule
Same index of refraction in all parts of the
lens
Pump mechanism regulating electrolyte
and water balance in the lens maintain
relative dehydration
LENS-METABOLISM
Any opacity in the lens or its capsule is
called CATARACT.
3 Basic mechanisms which cause cataract
are
1.Damage to the lens capsule that changes
its membranous properties
2.Change in the lens fibre protein synthesis
3.Increased lens hydration
PATHOGENISIS OF CATARACT
1.CORTICAL SENILE CATARACT
Its main biochemical features are
-Decreased levels of total proteins,
aminoacids and potassium associated with
increased concentration of sodium and
marked hydration of the lens followed by
coagulation of proteins
Mechanism of loss of
transparency
2.Nuclear senile cataract----
In it the usual degenerative change is
VITREOUS HUMOUR
Vitreous contain random collagen fibers
FUNCTIONS
Optic disc----It is a well defined, circular
pink coloured disc of 1.5mm diameter.It
has only nerve fiber layer, so it does not
excite any visual response.
STRUCTURAL CHARECTORISTIC OF
FOVEA CENTRALIS
All inner layers of retina are pushed aside
PHOTORECEPTORS
Photo sensitive compounds in the RODs
SCOTOPIC vision
According to absorption spectrum of
duplicity theory
MELANOPSIN ----Small number of
photoreceptors contain melanopsin
rather than RHODOPSIN OR cone
pigments.
They project to suprachiasmatic nuclei and
lateral geniculate nuclei controlling
pupillary responses to light.
---SYNAPTIC ZONE
Outer segments are modified
cilia
and made of regular stacks of
flattened saccules or disks
composed of membrane.
pigment epithelium
Rods are predominent in the extrafoveal
portions of RETINA.
Cones predominate in fovea
Extrafoveal portions there is a good deal
of convergence.
Flat bipolar cells make synaptic contact
with several cones
Rod bipolar cells make synaptic contact
with several rods
There are approximately 6 million cones
and
ELECTRICAL RESOPNSES
Receptor potentials of the photoreceptors and
electrical responses of other neural elements
are local graded potentials.
It is only in the ganglion cells that all or none
action potentials transmitted over appreciable
distances are generated.
Responses of the rods cones and horizontal
cells are hyperpolarising
responses of bipolar cells---Hyperpolarising or
depolarising
Amacrine cells—Depolarisig potentials &spike
that
result in generator potentials
Cone receptor potentials have sharp onset
and offset.
Rod receptor potential has a sharp onset
and a slow offset.
Amplitude of receptor potentials compared
to Stimulus intensity
CONE PIGMENT
VISUAL PIGMENTS
It is the photo sensitive visual pigment
present in the discs of ROD OUTER
SEGMENTS
It consists of a protein OPSIN(SCOTOPSIN)
and a CAROTENOID called RETINAL or
retenine1
Molecular weight----40000
Absorption spectrum of RHODOPSIN has a
peak sensitivity with limits493---505nm.It
absorbs primarily yellow wave length of light
transmitting VIOLET &RED to appear purple
RHODOPSIN(VISUAL PURPLE)
CONE PIGMENTS
3 Kinds of cones in primates.
Cone pigments differ from RHODOPSIN
in that they respond to specific
WAVELENGTHS of light giving rise to
Colourvision.
These differences are in OPSIN portion
of the molecule where as the chromophore
11-cis-retinal remains the same.
The peak absorbance wave -length of the
blue, green and red sensitive cones lie
at about 440,535 and 565nm respectively.
Light induced changes or photochemical
changes trigger a sequence of events that
cause PHOTO TRANSDUCTION .The photo-
-chemical changes occurring in the rods
and cones are similar,but they have been
studied in detail in the RODs and is
described as
Rhodopsin bleaching
Rhodopsin regeneration
Visual cycle
Light-induced changes
Rhodopsin
Light energy
BATHMO RHODOPSIN
OPSIN
LUMIRHODOPSIN
11 CIS- RETINAL
ISOMERASE METAHRODOPSIN-1
RHODOPSIN REGENERATION
ALL TRANS Metarhodopsin-ii
RETINAL
ISOMERASE
11 Cis- retinal All trans RETINAL
NADH
NADH
NAD
NAD
Isomerase
all –trans-retenal.
PHOTOTRANSDUCTION
Rhodopsin
Light energy
( minutes)
Bathmorhodopsin(ns)
opsin
LUMIRHODOPSIN (μs )
Metarhodopsin I( ms)
scotopsin
Metarhodopsin1I(s)
OF VISION
SCHEMATIC EYE
Total diopteric power +58D of which
CARDINAL DATA
The principal points P1 and P2 lie in the
REDUCED EYE
Total diopteric power----+60 D
The principal point lies 1.5 mm behind the
anterior surface of cornea
The nodal point is situated 7.2mm behind
the anterior surface of cornea.
The anterior focal point is 15.7mm in front
of the anterior surface of the CORNEA
Fovea(F).
Mechanism of accomodation--
Theories
When the eye is at rest the malleable
power in lens.
Zonules are kept under tension by a pull
Ocular changes in
accommodation
2.Changes in the curvature of lens surface
center.
4.Axial thickness - of lens is increased
takes place.
Chromatic abberations result owing to the
fact that the index of refraction of any
transparent medium varies with the
wavelength of incident light.
CHROMATIC ABERRATIONS
Myopic for blue and green rays.
Emmetropia can be defined as a state of
Emmetropia
Ametropia(A condition of refractive error)
is defined as a state of refraction,when
the parallel rays of light coming from
infinity are focused behind the retina in
one or both the meridia.
Ametropia
Hypermetropia (HYPEROPIA)or(LONG
SIGHTED NESS)
It is the refractive state of the eye where
in parallel rays of light coming from
infinity are focussed behind the retina
with accommodation being at rest.
HYPERMETROPIA
1.Axial hyper metropia---axial shortening of
eyeball.
ABOUT Imm shortening of anteroposterior
hypermetropia.
Mechanism of production
Curvatural hypermetropia is the condition
to aphakia
Features---FAR SIGHTEDNESS
-REECEEDING OF NEAR
POINT
-ASTHENOPIC Symptoms(headache,eye
ache ,tieredness,discomfort in reading.
Accommodative divergent squint.
Optical correction;
accommodation is at rest.
Mechanism of production---
Axial myopia
Curvatural myopia
Positional myopia
Index myopia
Accommodation; in uncorrected myopia is
clearly.
For this reason they may suffer from
Astigmatism
REGULAR ASTIGMATISM
Refractive power changes uniformly from
one meridian to another.
IRREGULAR ASTIGMATISM;
Irregular changes of refractive power in
Ciliary muscles
Pathophysiolgy of presbyopia
Symptoms
Difficulty of near VISION to start with in
evening later even in good light
Asthenopic symptoms due to fatigue of
the ciliary muscles after reading or near
work.
TREATMENT
Convex glasses for near work
Role of different cells in the
processing of retinal Image
Concept of receptive field
The receptive field is defined as the
influence area of a sensory neuron.It is
circular in configuration.The light falling in
the receptive field hyperpolarises the cell.
In the dark,ie when the photoreceptor is
depolarized a neurotrasmitter (glutamate)
is released from its terminal.When
hyperpolarised ,the photoreceptor will
release less neurotransmitter.
HORIZONTAL CELLS have very large
receptive field in comparison to the
photoreceptor cell. A Horizontal cell
transmits signels horizontally in the outer
plexiform layer from rods and cones to
the bipolar cells.Their main function is to
enhance the visual contrast by causing
lateral inhibition ie they play a role in
processing of spatial information.
BIPOLAR CELLS
There are two types of bipolar
cells,one type inhibited by
glutamate are depolarised
while other (excited by glutamate)
are hyperpolarized when the
photoreceptors are excited.
Thus the two different
types of bipolar cells
Provide opposing EXCITATORY and
INHIBITRY signels in the
VISUAL PATHWAY.
Receptive field of the bipolar cell is also
circular ,but shows a center surround
antagonism.In the case of centre
depolarising cell(on cell),the light striking
the centre of receptive field activates and
the light striking the surround inhibits
bipolar cell output.The reverse occurs in
the center hyperpolarising cell(off cell).
The size of the centre of the bipolar cell
receptive field is determined by the reach
of it’s dentrites that of much larger
surround is determined by the spread of
interconnected horizontal ell
This provides reciprocal relationship
between the depolarizing and bipolar cells
is that it provides a second mechanism for
lateral inhibition.(spacial information
processing).
In addition,this reciprocal relationship
allows half of the bipolar cells to transmit
positive signels and the other half to
transmit negative signels ;both have a
useful role in
Transmitting visual information to brain.
AMACRINE CELL
Amacrine cells receive information at the
synapse of bipolar cell axon with ganglion cell
dendrite and use this information for temporal
processing.They receive input from different
combinations of on-centre and off centre bipolar
cells.
The receptive fields of amacrine cells are
mixture of on centre and off centre regeon
Amacrine cells produce transient
depolarising potentials and spikes at the
onset and offset of visual stimuli.Amacrine
cells are the first cells in the visual pathway to
generate the impulse
GANGLION CELLS :The electrical
response of bipolar cells
(local graded potential) after modification
by the
amacrine cells
is transmitted to the ganglion cells which in
turn transmit their signals by means of
Action potential to brain
RECEPTIVE FIELD OF GANGLION CELLS
They also has got a centre surround
antagonism.
Functionally the ganglion cells are of 2
types
M ganglion cells(also called large ganglion
cells or Y cells)are concerned with
movement and stereopsis.
P ganglion cells (also called small ganglion
cells or X cells are concerned with
shape,colour and texture of the image