Name of Student Nurse: ESTRADA, CARISSA MAE T.

Date: JANUARY 29, 2023

Level/Block/Group: 3BSN-04 Clinical Instructor: Mrs. Liza Jane Biason
Basuel

VALPROIC ACID

NAME OF DRUG MECHANISM OF CONTRAINDICATI SIDE EFFECTS ADVERSE NURSING

ACTION ONS EFFECTS RESPONSIBILITIES
GENERIC NAME Valproic acid - Patients with - Nausea CNS: confusion, BEFORE:
exhibits its hepatic dizziness, - Take vital signs prior to
Valproic Acid pharmacologic disorders - Double vision headache, administration.
- Confirm medication on
effects in a couple sedation, ataxia,
BRAND NAME - Diarrhea medication ticket, medication
of ways, such as - Significant paresthesia, sheet, and doctor’s orders.
by acting on GABA hepatic asthenia, - Physical: Weight; skin color,
Aleptiz, Depacon, Depakene, -Vomiting
(γ aminobutyric impairment tremor, lesions; orientation, affect,
Epival, Depkote, Depakote ER
acid) levels in the drowsiness, reflexes; bowel sounds,
CNS, blocking - - Bleeding emotional normal output; CBC and
CLASSIFICATION problems differential, bleeding time
voltage-gated ion Hypersensitivity liability,
tests, LFTs, serum ammonia
channels, and to components abnormal
Pharmacologic Class: - High ammonia level, exocrine pancreatic
inhibiting histone of the drug and thinking, function tests, EEG
Carboxylic acid derivative levels in your
deacetylase. class of drug amnesia - History: Hypersensitivity to
blood valproic acid; hepatic
Therapeutic Class: EENT:
PHARMACOKINE - Urea cycle impairment; pregnancy,
Anticonvulsant, mood - Low body amblyopia, lactation
TICS disorders
stabilizer, antimigraine agent temperature blurred vision, - Perform handwashing prior
Absorption site: - Mitochondrial (hypothermia) nystagmus, to administration.
PREGNANCY CATEGORY: tinnitus,
Rapid absorption disorders, or
D - Allergic DURING:
from suspected pharyngitis
(hypersensitivity - Give drug with food if GI
INDICATION gastrointestinal disorders in
) reactions GI: Nausea, upset occurs
tract. patients <2- - Greet pt. and SO, verify
vomiting,
- Complex partial seizures year-old client identity (verbal, pt. tags,
- Drowsiness or diarrhea,
- Simple or complex absence Metabolism: bed number). Assess baseline
abdominal pain,
seizures metabolized almost -Pregnancy sleepiness in v/s
dyspepsia,
- Mania associated with bipolar entirely by the liver the elderly. anorexia, - Don’t give syrup in
disorder pancreatitis carbonated beverages (may
 Excretion: Less Hematologic: cause mouth and throat
DOSAGE & FREQUENCY than 3% of an leucopenia, irritation)
For Seizures: administered dose thrombocytopeni - Give IV only when oral
therapy isn’t feasible.
is excreted a
- For IV use, dilute valproate
Adults and children 10 years of unchanged in urine
sodium in at least 50 ml of
age or older—10 to Hepatic:
hepatotoxicity dextrose 5% in water, lactated
15mg/kg/day, dosage Half-life: 9-16
Musculoskeletal: Ringer’s solution, or normal
increased by 5 to hours
back pain saline solution. Infuse over 1
10mg/kg/week. gradually Respiratory:
Protein binding: hour at a rate slower than 20
increase your dose every week dyspnea
90% protein bound mg/minute.
by 5 to 10 mg per kg of body
weight as needed. Skin: rash, AFTER:
alopecia, - Closely monitor neurologic
For mania: brusing status. Watch for seizures.
Adults—At first, 750 milligrams Other: abnormal - Evaluate GI status. Stay
(mg) once a day, usually taste, increased alert for signs and symptoms
divided in smaller doses. Your appetite, weoght of pancreatitis.
doctor may increase your dose gain, flulike - Advise patient to
as needed. immediately report malaise,
symptoms,
Children—Use and dose must weakness, lethargy, appetite
infection,
be determined by your doctor. loss, vomiting or yellowing of
infusion site skin or eyes
For migraine: pain and - Document hour, amount,
Adults—At first, 250 milligrams reaction medication and drug reaction
(mg) 2 times a day. Your (if any)
doctor may increase your dose - Caution patient not to stop
as needed. However, the dose therapy abruptly.
is usually not more than 1000
mg a day.
Children—Use and dose must
be determined by your doctor.