UpToDate Causes of Chronic MR

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Causes of chronic mitral regurgitation

Leaflet Papillary muscles


Degenerative valve disease (mitral valve Ischemia or infarction
prolapse)
Dilated cardiomyopathy
Rheumatic fever
Left ventricular aneurysm
Infective endocarditis (acute and chronic)
Papillary muscle rupture
Systemic inflammatory disorders
Myocardial infarction
Systemic lupus erythematosus
Trauma
Scleroderma
Mitral annulus
Connective tissue disorders
Calcification
Marfan syndrome
Idiopathic
Ehlers-Danlos syndromes
Rheumatic fever
Pseudoxanthoma elasticum
Chronic renal failure
Congenital
Hyperparathyroidism
Mitral valve clefts
Dilation
Parachute mitral valve
Connective tissue disorder
Endocardial cushion defects
Dilated cardiomyopathy
Hypertrophic cardiomyopathy (systolic anterior
Myxomatous mitral valve
movement of mitral valve)
disease
Drug-related
Prosthetic valve
Chordae tendineae
Paravalvular leak
Myxomatous valve disease (mitral valve
Infective endocarditis
prolapse)
Ring or strut fracture
Infective endocarditis (acute and chronic)
Occluder dysfunction
Rheumatic fever
Pannus and/or
Spontaneous rupture
thrombus formation
Myocardial infarction
Leaflet deterioration (tissue
Trauma valves)
Graphic 64974 Version 4.0

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