ENDOTOXINS

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EXOTOXINS
Gram +/-
Gram - Proteins
Outer Membrane Type I Type III
Excreted
L.P.S.

S. Aureus V. Cholera
lipid a (immunogenic)
•
Activate Macrophages Type I Type II Type III
~

•• ooo Boo ooo

• • § Cholera
•

•••• •••• (m/c) Toxin

ooo B B
••••••••••••=
•• + ☒
•• ooo •• •• µ Activate Complement APc- ÷
.

TSST-1
• • +
•• ••
FI:
µ o-antigen System .
Watery
•• ooo
• • •• ••
C.P. oooo Diarrhea
•• •• •• •• T-Cell — IFN- ,
•• ooo • • •• ooo

Map (antigenic) TNF-

+
Activate Tissue Factor a
•

.•%••B⑧
•• ooo •• ••
p p
•
☒

+
IL-1 b
•• ooo ooo ooo •

factor iii Superantigen Direct Cell AB Toxin * § IL-2

☒ a.c.
•
T-Cell BARBARO
I.M. P.G. O.M. Inflammatory
Damaging ••
¥•aq*
Effect Injectisome APc
+ +
g protein
>

Response gtp c amp

+ %
: Booked iii atp
•

C3a C3a S. Aureus S. Aureus C. Diptheria + pka

BE TLR-4 C5a CI - CI - CI -
WEBER
to
+
Boi.BA p Boi.BG p Bad Bk p
""" ☒
•
*aa• + id =:&
CD15 C5a
vii + P. Aeruginosa Hypotension Rash Fever CI - CI - CI -
H 2O H 2O H 2O
TNF-M o rx o go ro
+
IL-1 N.O. + TSST-1
IL-6 •
Streptolysin
•
•
Enterotoxin Leukocidin Shigella
Thrombin +
Neutrophil
Vasodication Histamine Chemotaxis Fibrin + S. Pyogenes C. Perfringens
+ E. Coli Type II
+ sssss
Inflammation Tss
~

Cap. Permeability is
C. Perfringens
EDEMA
a -toxin V. Cholera
BLOOD PRESSURE
Erythrogenic
Toxin ↳wRÉwBq
Fever
B. Anthracis a -toxin
Clots Clotting
(Widespread) Proteins 1111 1111 1111 1111 1111
O2
÷ (Consumed) BOB •%a• pip2
✗ plc *

B. Pertussis a.a. TxA2 •

•

••
D.I.C. Bleed *

oac ip3 +
*
pkc ros *

C. Tetani 1. um

IL- 8

MULTISYSTEM ORGAN FAILURE Muscle Cell

C. Botulinum

Microbiology | Endotoxins vs. Exotoxins ☒ '

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