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Document From Matthew
Document From Matthew
inal
Physiology I
Part 1
Dr Lwiindi
(Medical
Physiologist)
Functions
4 major activities of GI tract
1. Motility
Propel ingested food from mouth toward rectum
2. Secretion
Aid in digestion and absorption
3. Digestion
Food broken down into absorbable molecules
4. Absorption
Nutrients, electrolytes, and water are absorbed
Structure of GI Tract
Arranged linearly in following
sequence
Mouth, esophagus, stomach, small
intestine, large intestine, and anus
Histamine
Secreted in H+-secreting region of
stomach
Stimulates H+ secretion by gastric
parietal cells (along with gastrin and ACh)
GI Neurocrines
Synthesized in cell bodies of GI
neurons
AP causes release of neurocrine
which interacts with receptors on
postsynaptic cell
adrenergic neurons)
Hormone Source Stmulus Stomach Pancreas Gall bladder
Motlity and
Secreton
1. Secretn S cells lining Acid entering Inhibits Stmulates
the duodenum duodenum fluid secreton
(HCO3-)
2. CCK Cells lining the Fat and amino Inhibits Stmulates 1. Contracton
duodenum acids entering emptying enzyme 2. Relaxaton
duodenum secreton sphincter
(Oddi)
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