Dr. B.

Lal Institute of Biotechnology

Pre University Examination 2019-2020
B.Sc. Biotechnology Part-III
Subject- Genomics & Proteomics

Time: 3hrs Max marks: 50

 Question 1 is compulsory

Q.1. Answer Following in Short 10

a) Comment upon QTL.
b) Define cot curves.
c) Differentiate between prokaryotic and eukaryotic genome packaging?
d) What is tetrad analysis?
e) Give an example of disease following autosomal recessive traits.
f) State two databases used to study protein-protein interactions.
g) What are motifs?
h) Comment upon homology modelling.
i) Comment upon multigene families.
j) What is the importance of repetitive DNA?

Section A
Q.2. Write short note on: 5+5
a) Linkage mapping in Neurospora crassa
b) Fine structure of eukaryotic gene
OR
Describe in detail the packaging of eukaryotic genome. 10

Section B
Q.3. Comment upon pedigree analysis in human. State the relevance of the same in context of
genetic diseases. 10

OR
Write short notes on: 10
a) Multigene families
b) C- value paradox

Section-C
Q.4. Explain in detail structural and functional proteomics. 10
OR
Write short notes on: 5+5
a) Protein modelling
b) Protein sequencing

Section-D
Q.5. Comment upon the techniques involved in determination of protein-protein interactions.
10

OR

Write short notes on: 5+5

a) Inter-relations of genomics with proteomics
b) Genome and proteome databases