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    Breast 1

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    Ramez Antakia
    This document discusses adjuvant treatment options for breast cancer based on various prognostic factors and test results. It outlines treatment pathways including chemotherapy, endocrine therapy, targeted therapies, and duration of treatment based on factors like tumor size and grade, age, menopausal status, presence of high risk features, and results from tests like Oncotype DX and PREDICT. The goal is to determine which patients would most benefit from additional adjuvant therapies following surgery to improve outcomes.

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    Breast 1

    Uploaded by

    Ramez Antakia
    3 views1 page
    This document discusses adjuvant treatment options for breast cancer based on various prognostic factors and test results. It outlines treatment pathways including chemotherapy, endocrine therapy, targeted therapies, and duration of treatment based on factors like tumor size and grade, age, menopausal status, presence of high risk features, and results from tests like Oncotype DX and PREDICT. The goal is to determine which patients would most benefit from additional adjuvant therapies following surgery to improve outcomes.

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    Chemotherapy treatment

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    Breast1

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    This document discusses adjuvant treatment options for breast cancer based on various prognostic factors and test results. It outlines treatment pathways including chemotherapy, endocrine therapy, targeted therapies, and duration of treatment based on factors like tumor size and grade, age, menopausal status, presence of high risk features, and results from tests like Oncotype DX and PREDICT. The goal is to determine which patients would most benefit from additional adjuvant therapies following surgery to improve outcomes.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    3 views1 page

    Breast 1

    Uploaded by

    Ramez Antakia
    This document discusses adjuvant treatment options for breast cancer based on various prognostic factors and test results. It outlines treatment pathways including chemotherapy, endocrine therapy, targeted therapies, and duration of treatment based on factors like tumor size and grade, age, menopausal status, presence of high risk features, and results from tests like Oncotype DX and PREDICT. The goal is to determine which patients would most benefit from additional adjuvant therapies following surgery to improve outcomes.

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    © All Rights Reserved
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    of 1

    Adjuvant

    treatment

    Post operative
    PREDICT/Nottingham
    Prognostic Index

    Will adjuvant
    therapy potentially
    help

    Highly Advantagous Poorly Advantageous

    Oncotype DX Adjuvant Endocrine

    ER+ HER2+
    Oncotype DX
    suggests chemotherapy useful.
    Tumour >0.5cm
    Trastuzumab &
    Pertuzumab
    Yes No with concurrent
    Chemotherapy
    (2-4 months)
    Adjuvant No Adjuvant
    Chemotherapy Chemotherapy

    12 m total
    Trastuzumab

    Age Pre-menopausal Post Menopausal

    Exemestane &
    <35 >40 Tamoxifen
    Ovarian Suppression

    Aromatase inhibitors
    High risk features Low risk featurea (Letrozole/ Anastrozole)
    10 years 5 years

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