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International Journal of Pharmaceutical and Biological Science Archive
NLM (National Library of Medicine ID: 101732687)
Index Copernicus Value 2019: 71.05
Volume 11 Issue 4; July-August; 2023; Page No. 1-10
Review Article

A Review of the Phytochemical and Pharmacological Potential of the


Watercress Plant (Nasturtium Officinale): A Medicinal Plant
Radha Chaudhary*1, Sunil Kumar2, Dr Jitendra Malik3, Gyan Singh4, Vinay
Kumar Siroliya5,
1
P.G Research Scholar, Faculty of Pharmacy, P.K University, Shivpuri, Madhya Pradesh, India
2
Associate Professor, Faculty of Pharmacy, P.K University, Shivpuri, Madhya Pradesh, India
3
Professor, Faculty of Pharmacy, P.K University, Shivpuri, Madhya Pradesh, India
4
Associate Professor, Faculty of Pharmacy, P.K University, Shivpuri, Madhya Pradesh, India
5
Assistant Professor, Faculty of Pharmacy, P.K. University, Shivpuri (M.P.) India
Received: 20-05-2023 / Revised: 30-06-2023 / Accepted: 13-07-2023
Corresponding author: Radha Chaudhary
Conflict of interest: Nil
Abstract
The plant Nasturtium officinale exhibits considerable potential as a medicinal source for drug
development, owing to its wide-ranging chemical composition and pharmacological properties. The
potential applications of this research encompass various fields such as drug development,
cardiovascular health, anti-inflammatory agents, anticancer potential, antimicrobial agents, and
dermatological treatments. The hypolipidemic properties exhibited by the plant have the potential to
effectively lower lipid levels in the bloodstream, thereby presenting itself as a viable avenue for the
management of cardiovascular diseases. The observed anticancer properties, ability to inhibit tumour
growth, and antimicrobial properties of this substance indicate promising prospects for v antibiotic
resistance. The dermatological effects exhibited by Nasturtium officinale show its potential as a viable
component in skincare formulations. The future trend of the pharmaceutical industry hinges upon the
continued investigation and exploration of its bioactive compounds, mechanisms of action, and
therapeutic efficacy. The establishment of partnerships among traditional healers, scientists, and
pharmaceutical companies has the potential to foster the development of novel medicinal products that
are both innovative and culturally sensitive. In a current review, the therapeutic benefits of Nasturtium
officinale come to attention.
Keywords: Nasturtium officinale, ingredients, pharmacology, therapeutic effects, alkaloids, flavonoids.

1. Introduction

There is an aquatic herb species of water plant [1,2]. In addition to a long history of use in both
that is a member of the Brassicaceae family culinary and medicinal contexts, watercress is
called Nasturtium officinale. This plant is more well-known for the bright green colour of its
generally known as watercress. It is indigenous leaves and the exquisite white blossoms that
to Europe and Asia, but it has now spread bloom on the plant. The plant known as
throughout most of the rest of the world thanks watercress is a perennial that prefers to establish
to widespread cultivation and naturalization its root system in soil or consistently damp

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water. It forms dense mats with creeping stems Vitamins A, C, and K are also present in
that can be up to 1 metre (3 feet) in length at its significant quantities in it. Scurvy, coughs, and
longest point. Pinnately compound leaves with digestive issues are only some of the conditions
short, spherical leaflets that have a flavour that have historically responded favorably to
similar to black pepper can be found on this treatment with watercress. It is considered to
plant. The tiny, white flowers are arranged in have qualities that are both diuretic and
clusters, and the seeds they generate are slightly expectorant, as well as anti-inflammatory. Due
oval [3]. to the numerous ways in which it may be utilised
Since ancient times, people have relied in culinary preparation, watercress has become
on watercress as a source of sustenance in their increasingly popular in recent decades. As a
culture. Because of the flavour that is both result of its high nutrient content, it is frequently
refreshing and slightly spicy, the leaves and recommended for use in cleansing diets and
stems of this plant are frequently eaten raw in eating plans that emphasise overall wellness.
dishes such as salads, sandwiches, and as a The plant known as Nasturtium officinale, more
garnish. Additionally, soups, stir-fries, and a commonly known as watercress, has been prized
wide variety of other foods can benefit from the throughout history for both its culinary and
addition of flavorful and nutritious watercress. medical use due to its exquisite flavour and high
In addition to its applications in the kitchen, nutrient content. Because it is able to flourish in
watercress has a long history of use as a wet situations, it is a one-of-a-kind plant that is
therapeutic herb. It is well known for its high highly desirable for use in horticulture and
nutritional value, and it is a wonderful source of culinary applications all over the world1,4,5].
minerals such as calcium, iron, and iodine.

Figure 1: Nasturtium officinale ( source : https://plantic.in/products/water-cress-imported)

2. Synonyms: cardaminefolium, Sisymbrium fluviatile,


Arabis nasturtium, Baeumerta nasturtium, Sisymbrium nasturtium, Sisymbrium
Baeumerta nasturtium-aquaticum, Cardamine nasturtium-aquaticum [3].
aquatica, Cardamine Fontana, Cardamine
nasturtium, Cardamine nasturtium-aquaticum, 3. Taxonomic classification:
Cardaminum nasturtium, Crucifera fontana, Kingdom: Plantae,
Nasturtium aquaticum, Nasturtium aquaticum, Subkingdom: Viridiplantae,
Nasturtium fontanum, Nasturtium nasturtium, Infrakingdom: Streptophyta,
Nasturtium nasturtium-aquaticum, Nasturtium Superdivision: Embryophyta,
officinale subsp. rotundifolium, Nasturtium Division: Tracheophyta,
siifolium, Radicula nasturtium, Radicula Subdivision: Spermatophytina,
nasturtium-aquaticum, Rorippa nasturtium, Class: Magnoliopsida,
Rorippa nasturtium-aquaticum, Rorippa Superorder: Rosanae,
nasturtium-aquaticum, Rorippa officinalis, Order: Brassicales,
Sisymbrium amarum, Sisymbrium Family: Brassicaceae,

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Genus: Nasturtium, Bulgaria, Croatia, Greece, Macedonia,


Species: Nasturtium officinale(22). Montenegro, Romania, Serbia, Slovenia,
Common names: France, Portugal, Spain); Australasia
Arabic: HabbArreshad; (Australia, New Zealand); Northern America
Chinese: dou ban cai; (Canada, Mexico, United States) and Southern
English: Watercress, bronkors; America (Barbados, Cuba, Dominica,
French: cressond'eau; Dominican Republic, Guadeloupe, Haiti,
German: Brunnenkresse, echte Brunnen- Jamaica, Martinique, St. Lucia, St. Vincent and
kresse; Grenadines, Trinidad and Tobago, United
Indonesian: selada-air; States, Guatemala, Nicaragua, Venezuela,
Japanese: mizu-garashi, oranda-garashi; Brazil, Bolivia, Ecuador, Peru , Argentina,
Portuguese: agrião; Chile, Uruguay)(2,3).
Spanish: berro(3).
5. Nutritional constituent:
4. Distribution: Watercress is an unique reservoir of essential
Nasturtium officinale is native to Western Asia, nutrients, boasting a rich abundance of vitamins
India, Europe, and Africa, However, It is and minerals. Watercress is considered a
distributed in Africa (Algeria, Egypt, Libya, nutritious dietary choice due to its rich
Morocco, Tunisia); Asia (Afghanistan, Iran, composition of various phytochemicals and
Iraq, Palestine, Jordan, Lebanon, Syria, Saudi essential nutrients. These components
Arabia, Turkey, Armenia, Azerbaijan, Georgia, contribute to promoting immune function and
Russian Federation, Kazakhstan, Kyrgyzstan, overall well-being in the human body.
Tajikistan, Turkmenistan, Uzbekistan, India, According to Al-Snafi et al. (2020), watercress
Pakistan, Nepal, Sri Lanka, Indonesia, Malaysia, is recognised as an essential source of vitamins
Philippines, China, Japan); Europe (Denmark, and is considered to possess detoxifying
Ireland, Sweden, United Kingdom, Austria, properties. Based on the available data, this
Belgium, Czech Republic, Germany, Hungary, report presents the chemical composition and
Netherlands, Poland, Slovakia, Switzerland, quantitative nutritional analysis of Nasturtium
Ukraine, Albania, Bosnia and Herzegovina, officinale, commonly known as watercress[2,3].

Table 1: Vitamins and phytochemicals [2,3]


Vitamins and phytochemicals Quantity/80 g edible produce

Calories (kcal) 18

Protein (g) 2.4


Fat (g) 0.8

Fibre (g) 1.2

Beta carotene (mcg) 2016

Vitamin A equivalent (mcg) 336

Vitamin B1 (mg) 0.13

Vitamin B6 (mg) 0.18

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Vitamin C (mg) 50

Vitamin E (mg) 1.17


Folate (mcg) 36

Vitamin K (mcg) 200

Table 2: Mineral composition of raw watercress Pandey et al.(2015) [2]


Mineral composition Quantity/80g edible produce

Calcium (mg) 136

Iodine (mcg) 12

Iron (mg) 1.8

Magnesium (mg) 12

Manganese (mg) 0.5

Phosphorus (mg) 42

Potassium (mg) 184

Zinc (mg) 0.6

Selenium (mcg) 1.6

Sodium (mg/100g) 68.8

Copper (mg/100 g) 0.58


Please note that the values provided are informational and may vary depending on plant variety, growing
conditions, and measurement methods.

6. Phytochemical and pharmacological effect on colon cancer HT29 cells against


potential of the watercress plant (Nasturtium oxidative DNA damage caused by different
Officinale) genotoxins, namely 4-Hydroxy Nonenal,
hydrogen peroxide, and faecal water[8]. In a
6.1. Anticancer study conducted by Hecht et al. (1995), it was
In addition to investigations into individual found that the intake of watercress, precisely
phytochemicals and essential nutrients, 56.8 g every three days, had inhibitory effects on
numerous studies have examined the notable the metabolic activities of NNK, a prominent
effects of N. officinale extracts, primarily tobacco carcinogen, in particular individuals
emphasising their chemo-preventive who smoke. In addition, the regular intake of 85
capabilities. In a survey conducted by Boyd et g of uncooked watercress on a daily basis over
al. (2006), it was observed that the application eight weeks resulted in a reduction of various
of watercress extract exhibited a protective indicators of DNA damage in Lymphocytes, a

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recognised biomarker for cancer. Furthermore, hepatotoxic effects induced by paracetamol.


this consumption led to an elevation in the levels This mechanism operates by preserving the
of the antioxidant compounds β-carotene and normal functioning of the liver. Based on an
lutein in the plasma. In a study conducted by extensive literature review, it can be inferred
Rose et al. (2005), it was shown that watercress that N. officinale holds significant importance as
extract, particularly the non-volatile 7- the a medicinal resource and an economically
component known as methylsulphinylheptyl valuable herb. Vegetables and salads are
isothiocyanate was found to decrease the commonly and extensively utilised in a
activity of MMP9 in the MDAMB-231 cell line, widespread manner. Furthermore, experimental
a type of human breast cancer[9]. evidence from previous years has demonstrated
their efficacy in combating specific diseases.
6.2. Antidiabetic The herb exhibits significant anticancer activity,
Diabetes currently represents a significant showing its full therapeutic potential[11,17].
health issue of concern in contemporary society. Biologically active compounds like
This disease holds considerable importance as it gluconasturtine are interesting due to their
gives rise to severe complications. According to potential physiological effects. In addition to its
Engelen et al. (2006), watercress has been found anticancer properties, it exhibits anti-diabetic
to contain a compound called gluconasturtin, and anti-tuberculosis effects. The properties
which belongs to a group of substances known mentioned include anti-inflammatory,
as glucosinolates. This compound has antimicrobial, and cardioprotective effects.
historically been used for the management of Therefore, it can be inferred that N. officinale
diabetes, a chronic endocrine disorder possesses the potential to serve as a viable
characterised by disrupted carbohydrate resource for the production and utilisation of
metabolism and increased levels of glucose in nutraceuticals and nutrient supplements.
the blood stream[10-15]. In their study on the Particularly significant for chronic illness. The
effect of N. officinale on blood glucose levels in Vitamins and mineral constituents of watercress
diabetic rats, Al-Snafi, A. E. (2020). They according to different sources (Pandey et al .,
observed a reduction in blood glucose levels 2018 ) are shown in Table 1 and 2,
comparable to the effects of glycyclamide, an respectively[2,5].
established anti-diabetic drug. As a result, the
researchers concluded that N. officinale has the 6.4.Antimicrobial effect:
potential to serve as a source of anti- Nasturtium officinale was tested for its ability to
hyperglycemic agents and contains inhibit the growth of Escherichia coli,
pharmacologically active component(s)[3]. Salmonella typhimurium, Staphylococcus
aureus, and Listeria monocytogenes using both
6.3.Anti-Tuberculosis, Cardio-Protective, aqueous and alcoholic extracts. Both the
And Hepatoprotective Properties. alcoholic and the aqueous extracts of Nasturtium
In their study, Corona et al. (2008) found that N. officinale had antibacterial activity. However it
officinale demonstrated the highest potency was more effective against Gram-positive
(MIC ≤ 100 µg/ml) among the four mono- bacteria than it was against Gram-negative
resistant variants tested against tuberculosis[10]. bacteria. With a minimum inhibitory
According to a study conducted by Kokhdan et concentration of 8 g/ml, S. aureus and L.
al. (2021), the administration of an alcoholic monocytogenes were the most sensitive
extract derived from the N. officinale plant at a bacteria. In tests conducted on S. aureus, the
dosage of 40 mg/kg demonstrated a significant MIC for the plant extract was found to be 6.25
reduction in liver damage caused by g/ml, and the MBC was found to be 12.5 g/ml.
acetaminophen in an in-situ rat liver model. N. However, E. coli and S. Typhimurium were
officinale potentially has a role to play[3,11]. resistant to the alcoholic and aqueous extracts
It has been observed that there is a protective (2,3).
mechanism in place that helps mitigate the

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The essential oil of Nasturtium officinale was reactions and direct heat were treated with
tested for its ability to inhibit the growth of watercress oil.
several vital food-borne germs, including Gram- When treated with watercress oil, the typical
positive bacteria like Staphylococcus aureus and architecture was restored more quickly,
Bacillus cereus, as well as Gram-negative considerably reducing the time needed to close
bacteria like Escherichia coli and Salmonella the burn(3,5).In normal human dermal
harmful bacteria: Escherichia coli and S. fibroblasts, the protective properties of indole 3-
enteric). S. enteric and E. coli showed the acetonitrile-4- methoxy -2- S--d-
highest resistance to the essential oil, whereas B. glucopyranoside (IAMG) from Nasturtium
cereus isolates displayed the highest level of officinale were investigated against ultraviolet
sensitivity (2,3). B-induced photodamage. According to the
findings, IAMG caused an increase in the
Nasturtium officinale had its methanolic extract migration of human dermal fibroblast cells.
put through antimicrobial tests against Bacillus IAMG therapy was able to reduce the UVB-
cereus, Enterococcus faecalis, Klebsiella induced elevations in MMP-1 as well as the
pneumonia, and Escherichia coli. The results decrease in type I procollagen. The findings
showed that the section has antibacterial action. provided compelling evidence that IAMG
The minimum inhibitory concentrations (MICs) derived from Nasturtium officinale mitigated the
of the extract against these bacteria were 0.6, photodamage caused by UVB (3,10-13]).
0.4, 0.8 and 0.6, whereas the minimum
inhibitory concentrations (MBCs) ranged from 6.7. Effects Beneficial to urinary tract health
0.10 to 0.8 mg/ml, respectively (2,3,8). Rats were given ethylene glycol in this
In this experiment, the antibacterial properties of experiment to promote kidney stone formation.
silver nanoparticles (Ag-NPs) from the aqueous Then the preventive effects of a hydrophilic
extract of Nasturtium officinale leaves were extract of Nasturtium officinale (750 mg/kg and
tested against the growth of Gram-positive (S. 1.5 g/kg of extract) were examined. The
aureus) bacteria. It was observed that the percentage of calcium oxalate crystals was 75%
inhibition occurred in the Ag-NPs against S. in the hostile control groups, 28.6% in the
aureus. The findings demonstrated that most S. preventive groups treated with a low dosage, and
aureus was severely harmed and eliminated due 57.1% in the preventive groups treated with a
to the addition of Ag-NPs(3,9). high dose. We see that in contrast to the healthy
The in vitro synergism between aqueous and control group (12.5%). The oxalate
methanolic extracts of Nasturtium officinale and concentration in the urine was higher in the
2-phenyl ethyl isothiocyanate, discovered in preventive and opposing control groups than in
Nasturtium officinale, was carried out against the healthy control group (P 0.05) (3,8).
conventional antibiotics. The tested organisms
included Escherichia coli, Klebsiella 6.8. Antigenotoxic impact: The effect of
pneumoniae, and Escherichia coli. 11 different aqueous extract (two concentrations: 13.2 and
strains of Escherichia coli with extended- 26.4 mg/ml) on cell viability and its possible
spectrum beta-lactamases. When the antibiotics antigenotoxic qualities against induced
were mixed with plant extracts and 2-phenyl oxidative damage were evaluated utilising a
ethyl isothiocyanate, the results showed an comet assay and in vitro microsome analysis. In
increase in the antibacterial activity of the vitro model using cells taken from the peripheral
antibiotics (3,9). blood. At no point was there a detectable
difference in the levels of cell viability between
6.5. Dermatological effect: the control group and the treatment group.
The ability of watercress oil to promote wound Significant antigenotoxic effects were seen at
healing following thermal and chemical burns in both concentrations (p = 0.005 at 30 min; P
rabbits was investigated in this study. The 0.001 at 60 and 90 min), with the percentage
experimental burns caused by chemical reductions in damage being comparable

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between the concentrations that were employed ethanolic extract of Nasturtium officinale was
(67.1% and 75.2%, respectively(3,12). investigated in mice at doses ranging from 0.5 to
5,000 milligrammes per kilogramme of body
6.9.Thyroid disease weight (mg/kg bw). The maximum quantity did
Based on present studies, there needs to be more not result in any deaths, and the animals
scientific evidence that establishes a causal remained in their usual conditions. There were
relationship between watercress consumption no statistically significant variations in the
and thyroid function. Nevertheless, it is crucial relative weights of the mice's liver, heart, or
to acknowledge that watercress belongs to the kidneys across any of the doses. According to
Brassicaceae family, encompassing various the findings of histopathological research, the
vegetables such as broccoli, cabbage, and kale. most incredible doses induced necrosis and
These vegetables are recognised for their hydropic degeneration of the liver and kidneys,
elevated levels of glucosinolates, which can as well as an inflammatory manifestation of the
potentially disrupt thyroid function when heart with a myofibril irregular heart(3,6).
consumed excessively, especially among
individuals with insufficient iodine levels. The 8. Use of Nasturtium officinale in traditional
catabolism of glucosinolates in the body gives and value-added foods [17-24]
rise to compounds that have the potential to Nasturtium officinale, sometimes known as
impede the uptake of iodine within the thyroid watercress, is a plant extensively utilised in
gland. Due to its crucial role in synthesizing traditional and value-added culinary products.
thyroid hormones, an insufficiency of iodine can Here is some information on its applications:
result in hypothyroidism, characterized Watercress has a long history of culinary use in
by diminished thyroid gland activity. This traditional meals, particularly in European and
condition can induce various symptoms, Asian cuisines. It is well-known for its peppery
including fatigue, weight gain, and depression and slightly bitter flavour, which gives foods a
[15-19]. distinct flavour. Here are a few examples of how
watercress is utilised in traditional cuisine:
7. Adverse reactions and harmful effects:
Mice were used for the research on in vivo acute Salads: Watercress is a popular fresh element in
toxicity. The mouse subjects were subjected to a salads. Its soft leaves and stems are frequently
stressful experience at varying levels due to the combined with other greens, vegetables, and
plant extract's acute oral toxicity, particularly at dressings to make light, healthy salads.
80 mg/kg and 100 mg/kg. Within eight hours of
receiving the gavage, some clinical symptoms Soups and stews: Watercress adds flavour and
were observed, including intense agitation, nutrition to soups and stews. Add it near the end
followed by immobility. Several fatalities were of the cooking process to keep its crispness and
found after 72 hours, with LD50 values ranging brilliant green colour.
from 50 to 500 mg/kg body weight (45). The Watercress can fill or garnish in sandwiches,
acute and sub-acute effects of oral wraps, or rolls, adding a crunchy texture and a
administration of a standardised extract of distinct flavour.
Nasturtium officinale containing 5.0 mg/ml of
phenyl ethyl glucosinolate were investigated in Stir-fries: Watercress is stir-fried with
rats as part of a safety study. The LD50 was vegetables, meats, or shellfish in some Asian
somewhere between 2 and 5 grammes per cuisines to make a quick and tasty dish.
kilogramme. According to the findings, Watercress is used in value-added food items,
Nasturtium officinale extract at doses up to 5 processed or blended with other ingredients to
g/kg in acute studies was safe. In comparison, produce new gourmet experiences in addition to
sub-acute administrations of the extract up to 1 its conventional applications. Here are a couple
g/kg were found to have no deleterious effects of such examples:
(51, 85). However, the acute toxicity of an

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Pesto: In pesto, watercress can be used in place 500 mg/kg of body mass. The extract was
of or in addition to regular basil. The watercress investigated in rats using both acute and sub-
pesto has a bright green colour and a distinct acute oral dosages. The LD50 value fell within
flavour profile. Watercress can be mixed with 2-5 grammes per kilogramme. In the critical
other fruits and vegetables to make nutrient- study, administering a dosage of up to 5g/kg was
dense smoothies and drinks. It offers a pleasant deemed safe, as no detrimental effects were
flavour while also providing essential vitamins observed. No adverse effects were observed
and minerals. during the sub-acute administration of up to
1g/kg. A separate investigation assessed the
Sauces and Dressings: Watercress can increase immediate toxicity of an ethanolic extract
the flavour and nutritional value of sauces, derived from Nasturtium officinale in mice,
dressings, and dips. It can be blended with other utilising a range of doses (0.5, 5, 50, 500, 1000,
ingredients such as yoghurt, lemon, garlic, or 2000, and 4000 mg/kg body weight). The
herbs to make a variety of condiments. administration of the highest dosage did not
Watercress can be used with butter to make result in mortality, and the animals' observed
flavoured butter spreads. This adds a delightful behaviour and physical characteristics remained
twist to toast and as a topping for cooked veggies within the expected range[3]. Nevertheless,
or grilled meats. histopathological investigations revealed that
administering the highest doses resulted in liver
Watercress Infused Oils and Vinegars: and kidney necrosis and hydropic degeneration.
Watercress can be infused into oils or vinegar to An inflammatory response in the heart was also
add flavour and colour. These scented products observed, characterised by irregular myofibrils.
can be used as salad dressings or garnish in Based on the provided data, it can be inferred
various cuisines. Overall, watercress, or that administering Nasturtium officinale extract
Nasturtium officinale, is a versatile plant that in excessive quantities may exhibit toxicity,
may be used in traditional and value-added impacting the liver, kidneys, and heart.
foods. It is a favourite choice among chefs and Nevertheless, it is crucial to acknowledge that
food followers due to its peppery flavour, the studies mentioned above were carried out on
brilliant colour, and nutritional benefits. murine and rodent models, and it is only
sometimes valid to extrapolate the same
9. Side effects and toxicity: outcomes to the human population. Additional
The in vivo acute toxicity was studied in mice. investigation is required to ascertain the safety
The data presented appears to be derived from a profile and potential adverse reactions
scientific investigation or investigations associated with administering Nasturtium
examining the acute toxicity of Nasturtium officinale extract in human subjects[3,23-27].
extracts in mice and rats. Based on the
information provided, the section can induce 10. Conclusion
toxicity when administered in high Nasturtium officinale, also known as watercress,
quantities[3,21-24].In the context of acute oral is a botanical species with a distinctive pungent
toxicity tests conducted on mice, it was observed taste and significant nutritional composition. It
that the extract elicited notable stress-inducing is a rich source of essential nutrients, including
effects, mainly when administered at doses of vitamins A, C, and K, and minerals like calcium,
80mg/kg and 100mg/kg. Mice exhibited a manganese, and potassium. Watercress has been
noteworthy state of heightened agitation used for its therapeutic properties, including
followed by a subsequent period of immobility enhancing respiratory well-being and acting as a
within eight hours after administration. diuretic. Extensive investigations have explored
Mortalities were recorded after a 72-hour period, its potential medicinal advantages, including its
wherein the LD50 (the dosage necessary to potential role in cancer prevention and
induce mortality in 50% of the experimental treatment. Watercress contains isothiocyanates,
cohort) exhibited a range spanning from 50 to which have been extensively investigated for

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their potential anti-cancer properties. 6. Clemente, M., Miguel, M., Gribner, C.,
Additionally, its antioxidant properties are Moura, P. F., Rigoni, A. A. R., Fernandes, L.
attributed to its high concentration of vitamins C C., & Miguel, O. G. (2019). Watercress, as a
and E. These antioxidants can help prevent functional food, with protective effects on
chronic illnesses like cardiovascular disease and human health against oxidative stress: A
cancer. Despite the nutritional advantages of review study. Int. J. Med. Plants Nat.
watercress, much of the evidence regarding its Prod, 5, 12-16.
medicinal properties is still in its early stages. 7. Lata, M. (2020). Nutritional, medicinal and
Further research and scientific publications are indigenous use of Nasturtium officinale in
essential to validate and understand its effects. Tehsil Thunag of District Mandi, Himachal
Monitoring ongoing research and publications is Pradesh, North Western Himalayas,
crucial to stay updated on emerging India. International Journal of Chemical
advancements in health benefits and Studies, 8(5), 1648-1653.
pharmaceutical applications of Nasturtium 8. Boyd, L. A., McCann, M. J., Hashim, Y.,
officinale. Healthcare practitioners should also Bennett, R. N., Gill, C. I., & Rowland, I. R.
be consulted for guidance on using medicinal (2006). Assessment of the anti-genotoxic,
plants for therapeutic purposes. anti-proliferative, and anti-metastatic
potential of crude watercress extract in
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