Good Morning Sir so today im going to talk about Clonorchis Sinensis so what

what is Clonorchis sinensis Clonorchis sinensis is also called liver fluke parasite

that humans can get by eating raw or undercooked fish from areas where the
parasite is found. Found across parts of Asia, Clonorchis is also known as the
Chinese or oriental liver fluke. Liver flukes infect the liver, gallbladder, and bile
duct in humans. So what is the Importance Properties and Life Cycle so there are
three morphologic stages of the parasite the egg, larva, and adult. The egg have
an operculum surrounded by a thick rim called the shoulder. The first
intermediate host is the freshwater snail while the second intermediate host is a
freshwater fish. Within the egg is developed miracidium that is released once the
egg comes into contact with freshwater. The miracidium penetrates the first
intermediate host and develops into a sporocyst that contains numerous larval
stages called the rediae. The larvae are then released into the water where they
transform into cercariae. The cercariae enter a freshwater fish where they encyst
to become the metacercariae. The larvae excyst in the duodenum, enter the
biliary ducts, and differentiate into adults. The adult worms produce eggs that are
excreted in the feces. Humans acquire the infection by ingesting raw or
undercooked freshwater fish containing the infective metacercariae. So next is
the Epidemiology and Pathogenesis so Clonorchis sinensis is found in Asia
including Korea, China, Taiwan, Vietnam, Japan, and Asian Russia (Center for
Disease Control and Prevention). So Ang parasite ay hindi karaniwang nagiging
sanhi ng makabuluhang mga sugat, gayunpaman, ang mga parasite na
naninirahan sa mga duct ng apdo ay maaaring makapinsala sa biliary tract. Ang
mga pasyente na nagkakaroon ng impeksyon sa parasite ay nasa mas mataas na
panganib na magkaroon ng cholangiocarcinoma o kanser sa mga duct ng apdo.
Ang itlog ay naiugnay din sa pagbuo ng mga gallstones (mga bato sa gallbladder o
cholelithiasis). So next ay Disease Clonorchiasis Karamihan sa mga pasyente ay
asymptomatic. In heavy worm burden, ang mga pasyente ay maaaring magpakita
ng lagnat, sakit sa tiyan, anorexia, hepatomegaly, pagtatae, at eosinophilia. Liver
dysfunction may also occur in chronic infection associated with heavy worm
burden. So yung Laboratory Diagnosis ng Clonorchis sinensis ay itinatag sa
pamamagitan ng paghahanap ng mga katangian ng egg sa stool specimen o
duodenal aspirates. So the treatment The drug choice for treatment is
praziquantel. And the alternative drug is albendazole. And the Prevention and
Control naman niya ay pwedeng maiwasan ang impeksyon sa pamamagitan ng
maayos na pagluluto ng isda bago kainin. Iba pang control Kasama sa mga
hakbang ang edukasyon sa kalusugan, tamang pagtatapon ng basura to avoid
contamination of bodies of fresh water, and prompt treatment of infected
persons. Yung lang po.