(d) Adjuvant therapy

49. Orally active hormone is:

(Recent NEET Pattern Question)
(a) TSH
(b) Thyroxine
(c) GH
(d) Prolactin

50. Drug of choice for the treatment of hyperthyroidism in pregnancy is:

(Recent NEET Pattern Question)
(a) Propylthiouracil
(b) Radio iodine
(c) Carbimazole
(d) Iodides

51. Thyroxine is used in the treatment of which thyroid cancer:

(Recent NEET Pattern Question)
(a) Medullary
(b) Radiation induced
(c) Anaplastic
(d) Papillary
52. Allof the following reduce T, absorption except:
(Recent NEET Pattern Question)
(a) Metformin
(b) Iron salts
(c) Raloxifene
(d) Colsevelam

PANCREAS AND DIABETES MELLITUS

53. A diabetic and hypertensive patient taking several drugs presented with
septicemia. Serum creatinine levels are 5.7 mg/dL. Which of the following
drug should be stopped?
(AIIMS Nov 2017)
(a) Insulin
(b) Metoprolol
(c) Linagliptin
 (d) Metformin

54. A diabetic patient presented with uncontrolled blood sugar level. He has history
of pancreatitis and family history of urinary bladder carcinoma. He is allergic
to sulfonylureas and do not want to take injectable drugs. Which of the
following drug can be added to control his blood sugar?
(AIIMS Nov 2017)
(a) Liraglutide
(b) Sitagliptin
(c) Canagliflozin

(d) Glipizide

55. A 70-year-old patient has diabetes mellitus and hypertension. He presents with
renal failure and does not want to take injectable drugs. Which anti-diabetic
drug will you prefer in this patient that does not require dose modification in
renal disease?
(AIIMS May 2017)
(a) Linagliptin
(b) Vildagliptin
(c) Exenatide
(d) Metformin

56. Components of lente insulin are:

(AIIMS May 2017)
(a) 30% amorphus + 70% crystalline
(b) Amorphous
(c) 30% crystaline + 70% amorphus
(d) Same as NPH insulin

57. All are preferred sites of insulin administration except:

(AIIMS Nov 2016)
(a) Thigh
(b) Buttocks
(c) Dorsum of arm
(d) Around umbilicus

58. A well-known complication of mnetformin therapy is lactic acidosis. All are risk
factors for increased lactic acidosis in patient on metformin therapy except:
(AIIMS Nov 2016)
(a) Advanced age
 (b) Liver dysfunction
(c) Renal dysfunction
(d) Smoking

59. Which of the following anti-diabetic drugs does not need dose reduction in a
patient with renal disease?
(AIIMS Nov 2016)
(a) Sitagliptin
(b) Linagliptin
(c) Vildagliptin
(d) Saxagliptin
60. All of the following antidiabetic drugs act by enhancing insulin secretion
except
(AlIMS May 2015)
(a) Exenatide
(b) Sitagliptin
(c) Rosiglitazone
(d) Repaglinide
61. Which of the following is secreted by beta cells of pancreas along with insulin?
(AIIMS May 2015)
(a) Somatostatin
(b) Amylin
(c) Pancreatic polypeptide
(d) Glucose like peptide
62. Which of the following anti-diabetic drugs can cause vitamin Bp deficiency?
(AI2012)
(a) Glipizide
(b) Acarbose
(c) Metformin
(d) Pioglitazone
63. Which of the following drugs does not cause hypoglycemia:
(AIIMS May 2011)
(a) Acarbose
(b) Insulin
(c) Glimepride
(d) Nateglinide
64. A patient is receiving insulin and acarbose for diabetes mellitus and developed
hypoglycemia. Which of the following should be used for treatment of
hypoglycemia in this patient?
(AIIMS May 2011)
(a) Sucrose
(b) Galactose
(c) Glucose
(d) Starch
65. True about pioglitazone are all except:
(AIIMS May 2011)
(a) Metabolized in the liver by CYP3A4
(b) Selective agonist for the nuclear peroxisome profilerator activated
receptor gamma
(c) It causes transcription of gene for carbohydrate and fat metabolism in the
absence of insulin
(d) It should be avoided in a patient with cardio-vascular disease
66. All of the statements about exenatide are true except:
(a) It is a GLP -1 analogue
(AIIMS May 2011)
(b) It can be used for treatment of Type 1 diabetes mellitus
(c) It is given subcutaneously
(d) It decreases glucagon

67. All of the following statements about nateglinide are true except?
(AI 2011)
(a) Decreases post-prandial hyperglycemia
(b) Hypoglycemia is less common than with sulfonylureas
(c) It decreases insulin resistance
(d) It acts by releasing insulin

68. Insulin causes all of the following except:

(AIIMS May, 2010)
(a) Glycogenesis
(b) Glycolysis
(c) Lipogenesis
(d) Ketogenesis

69. What will happen if insulin alone is given rapidly in Diabetic Ketoacidosis?
(AI 2009) (AIIMS May, 2010)
 (a) Hypokalemia
(b) Hypernatremia
(c) Hyperkalemia
(d) Hypocalcemia

70. Which of the following statements regarding acarbose is FALSE?

(DNB 2008, AIIMS Nov, 2008)
(a) It acts by inhibiting the enzyme alpha-glucosidase
(b) It reduces post-prandial hyperglycemia
(c) It decreases the progression of impaired glucose tolerance to overt
diabetes mellitus
(d) It can cause hypoglycemia

71. All of the following preparations of insulin are rapid and short acting except:
(AI2007)
(a) Lispro
(b) Aspart
(c) Glargine
(d) NPH

72. Which of the following statements about biguanides is NOT true?

(AI 2004)
(a) Donot stimulate insulin release
(b) Decrease hepatic glucose production
(c) Renal dysfunction is not a contraindication for their use
(d) Can be combined with sulfonylureas

73. All the following statements about alpha-glucosidase inhibitors are true except:
(AI2004)
(a) Reduces intestinal absorption of carbohydrates
(b) Effective in both type 1 and 2 diabetes
(c) Hypoglycemia is a common and serious side effect
(d) Can be used with other oral hypoglycemic agents
74. If a diabetic patient being treated with an oral hypoglycemic agent develops
dilutional hyponatremia, which one of the following could be responsible for
this effect?
(AIIMS Nov, 2003)
(a) Chlorpropamide
(b) Tolbutamide
 (c) Glyburide
(d) Glimepride

75. All of the following are true about metformin except:

(AIIMS May, 2002)
(a) Causes little or no hypoglycemia in non diabetic patients
(b) Acts by increased insulin secretion
(c) Increases peripheral utilization of glucose and decreases absorption of
glucose from intestine
(d) When given with alcohol, increases risk of lactic acidosis
76. Insulin causes:
(Recent NEET Pattern Question)
(a) Nat entry into cells
(b) K*exit from cells
(c) Na' exit/ K* entry
(d) K* entry into cells

77. Which of the following is not used for the treatment of insulin induced
hypoglycemia?
(Recent NEET Pattern Question)
(a) Intravenous glucose
(b) Glucagon
(c) Adrenaline
(d) Oral carbohydrates
78. Sulfonylureas act by:
(Recent NEET PatternQuestion)
(a) Decreasing glucagon secretion from pancreas
(b) Decreasing insulin secretion from pancreas
(c) Increasing gluconeogenesis
(d) Increasing insulin secretion from pancreas

79. Flushing is common in patient taking which of the following oral

hypoglycemic drug with alcohol:
(Recent NEET Pattern Question)
(a) Chlorprompamide
(b) Phenformin
(c) Glibenclamide
 (d) Tolazamide

80. Anti-diabetic effect of sulfonylureas is by reducing:

(a) Glucagon production
(Recent NEET Pattern Question)
(b) Insulin secretion
(c) Tissue sensitivity to insulin
(d) Tissue sensitivity to glycogen

81. Lactic acidosis is common in:

(Recent NEET Pattern Question)
(a) Metformin
(b) Phenformin
() Repaglinide
(d) Rosiglitazone
82. Tolbutamide acts by increasing:
(Recent NEET Pattern Question)
(a) Insulin receptors
(b) Glucose entry
(c) Glucose absorption
(d) Insulin secretion

83. Adverse effects of insulin include all of the following except:

(Recent NEET Pattern Question)
(a) Edema
(b) Hyperglycaemia
(c) Lipodystrophy
(d) Allergy

84. Long acting insulin is:

(Recent NEET Pattern Question)
(a) Lente
(b) Semilente
(c) Ultralente
(d) Lispro insulin

85. 2nd generation sulfonylurea drugs are all except:

(Recent NEET Pattern Question)
(a) Glipizide
 (b) Gliclazide
(c) Tolbutamide
(d) Glibenclamide

86. Which of the following drug is alpha-glucosidase inhibitor?

(Recent NEET Pattern Question)
(a) Pioglitazone
(b) Miglitol
(c) Metformin
(d) Nateglinide

87. Monotherapy with which of the following antidiabetic drug can cause
hypoglycemia?
(Recent NEET Pattern Question)
(a) Metformin
(b) Glibenclamide
(c) Pioglitazone
(d) All of the above
88. Which of the following is not a starting criteria for sulfonylurea therapy?
(Recent NEET Pattern Question)
(a) Total pancreatectomy
(b) NIDDM
(c) Diabetes after 60 years
(d) None

89. Oral hypoglycemic drug that is less likely to cause hypoglycemia is:
(Recent NEET Pattern Question)
(a) Repaglinide
(b) Gliclazide
(c) Rosiglitazone
(d) Glimipiride
90. All of the following are true regarding chlorpropamide except:
(Recent NEET Pattern Question)
(a) It is short acting
(b) It can cause hypoglycemia in elderly
(c) Causes weight gain
(d) Associated with alcoholic flush
91. Common side effect of thiazolidinediones is:
(a) Dysguesia
(Recent NEET Pattern Question)
(b) Hypoglycemia
(c) Water retention with weight gain
(d) Anemia

92. Long acting insulin preparations are frequently admini-stered by:

(Recent NEET Pattern Question)
(a) Oral route
(b) Intramuscular route
(c) Intradermal route
(d) Subcutaneous route
93. Glipizide, the oral hypoglycaemic drug acts by:
(Recent NEET Pattern Question)
(a) Improving insulin resistance
(b) Inhibiting brush border enzyme
(c) Helps in insulin secretion
(d) Increased glucose uptake by fat cells

94. Which is an intermediate acting insulin?

(Recent NEET Pattern Question)
(a) Insulin lispro
(b) Regular insulin
(c) NPH insulin
(d) Insulin glargine

95. Which of the following does not cause insulin release?

(Recent NEET Pattern Question)
(a) Rosiglitazone
(b) Nateglinide
(c) Glimipiride
(d) Tolbutamide

96. Which of the following can cause lactic acidosis?

(Recent NEET Pattern Question)
(a) Biguanides
(b) Glibenclamide
(c) Tolbutamide
 (d) Chlorpropamide

97. Glucagon is most effective for which of the following conditions?

(Recent NEET Pattern Question)
(a) Cocaine intake with BP of 180/110mmHg
(b) Old man with decreased BP/decreased heart rate due to atenolol
(c) Old man with type 2 diabetes mellitus and noglipizide for 4 days
(d) Female with lactic acidosis due to shock
98. Which insulin is never mixed with other insulins?

(a)Lente
(Recent NEET Pattern Question)
(b) Aspart
(c) Lispro
(d) Glargine

99. Insulin release due to closure of K* channels is seen with:

(Recent NEET Pattern Question)
(a) Nateglinde
(b) Acarbose
(c) Exenatide
(d) Sitagliptin

100. Drug used to control postprandial hyperglycemia is:

(Recent NEET Pattern Question)
(a) Acarbose
(b) Biguanides
(c) Sulfonylurea
(d) Repaglinide
101. Long acting insulin is?
(Recent NEET Pattern Question)
(a) Insulin glargine
(b) Insulin lispro
(c) Insulin aspart
(d) Insulin glulisine
102. Which of the following is not an insulin analogue?
(Recent NEET Pattern Question)
(a) Insulin glargine
 (b) Insulin lispro
(c)Actrapid
(d) Insulin aspart

103. Which of the following does not cause hypoglycemia?

(Recent NEET Pattern Question)
(a) Insulin
(b) Glimepiride
(c) Metformin
(d) Gliclazide

104. Sulphonylureas act by:

(Recent NEET Pattern Question)
(a) Reducing the absorption of carbohydrate from the gut
(b) Stimulating the beta islet cells of pancreas to release insulin
(c) Increasing the uptake of glucose in peripheral tissue
(d) Reducing the hepatic gluconeogenesis
105. All of the following drugs used in the management of diabetes mellitus cause
hypoglycemia except:
(Recent NEET Pattern Question)
(a) Metformin
(b) Tolbutamide
(c) Glibenclamide
(d) Glipizide
106. Which of the following drugs used to treat type II diabetes mellitus causes
weight loss:
(Recent NEET Pattern Question)
(a) Metformin
(b) Glimepiride
(c) Repaglinide
(d) Gliclazide
107. Most important step in management of diabetic ketoacidosis is administration
of:
(Recent NEET Pattern Question)
(a) Insulin
(b) Intravenous fluids (saline)
(c) Soda-bicarbonate
 (d) Potassium
108. The following insulin can be given intravenously:
(Recent NEET Pattern Question)
(a) Protamine zinc insulin
(b) Ultra lente insulin
(c) Semi lente insulin
(d) Regular insulin

CORTICOSTEROIDS

109. Which of the following regimen of antenatal steroids is preferred for fetal lung
maturation?
(AIIMS Nov 2016)
(a) Dexamethasone 6 mg 12 hourly 4 doses
(b) Betamethasone 6 mg 12 hourly 4 doses
(c) Dexamethasone 12 mg 12 hourly 4 doses
(d) Betamethasone 12 mg 12 hourly 4 doses
110. Steroids are used in all of the following conditions except?
(AIIMS Nov 2015)
(a) Chronic Lymphoid Leukemia
(b) Hodgkin's lymphoma
(c) Multiple myeloma
(d) Kaposi's sarcoma
111. Allof the following are seen in adrenal insufficiency except?
(AIIMSNov 2015)
(a) Hyperkalemia
(b) Fever
(c) Weight gain
(d) Postural hypotension

112. Dose of dexamethasone given to mother in anticipated preterm delivery:

(AIIMS May 2015)
(a) 12 mg 12 hourly 2 doses
(b) 12 mg 24 hourly 4 doses
(c) 6 mg 24 hourly 2 doses
(d) 6 mg 12 hourly 4 doses