MADONNA UNIVERSITY, ELELE CAMPUS

FACULTY OF SCIENCE DEPARTMENT OF BIOCHEMISTRY TOPIC: PREENTER: REG.NO: STRUCTURE AND FUNCTION OF SIDEROPHORES NNANNA ELVIS CHINEDU BC/07/065

COURSE TITLE: SEMINAR IN BIOCHEMISTRY COURSE CODE: BCH 418 SUPERVISOR: DATE: MR. LUKONG C. BANBOYE 24TH NOVEMBER, 2010

IN PARTIAL FULFILLMENT OF THE COURSE BCH 418 FOR THE AWARD OF BACHELOR OF SCIENCE (B.Sc) DEGREE IN BIOCHEMISTRY.

ABSTRACT Microorganisms synthesize and secrete small organic molecules called siderophore that actively chelate iron and remove it from eukaryotic ironbinding proteins..Siderophores are common products of aerobic and facultative anaerobic bacteria and of fungi. Elucidation of the molecular genetics of siderophore synthesis, and the regulation of this process by iron, has been facilitated by the fact that E. coli uses its own siderophores as well as those derived from other species, including fungi. Siderophores are transported across the double membrane envelope of E. coli via a gating mechanism linking the inner and outer membranes. In addition, they have clinical applications and are possibly important in agriculture. PRESENTATION OUTLINE Introduction Coordination Chemistry Structure of Iron-Binding Microbial Siderophores Biological Function Biosynthesis of Siderophores Regulation of Siderophores Mechanism of Siderophores Transport and Uptake Application of Siderophores Conclusion

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