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Group 3 Answers - Acetaminophen
Group 3 Answers - Acetaminophen
1. In the case study, patient is admitted to the hospital because of acetaminophen (Tylenol)
overdose. Overdoses of acetaminophen can precipitate life-threatening abnormalities in which
organ? Explain.
Over many years, it has been used countless times by many people, and it has proven to be a safe
and effective medication. However, if taken in excess amounts (overdose, whether on purpose or by
accident), acetaminophen can cause life-threatening illness.
Acetaminophen in overdose can seriously damage the liver. If the damage is severe, a liver
transplant may be necessary in order to save someone’s life. Acetaminophen is primarily metabolized
by the liver. Too much acetaminophen can overwhelm the way the liver normally functions.
3. Which tests are the most sensitive marker of injury caused by acetaminophen poisoning?
a. INR
d. Alkaline phosphatase
As with any ingestion, assessing for other potential life-threatening co-ingestants is very
important. Administer activated charcoal (AC) if the patient has a stable mental and clinical
status, patent airway, and presents to the emergency department within 1 hour of ingestion.
3
References:
KhabazianZadeh, F., Kazemi, T., Nakhaee, S., Ng, P. C., & Mehrpour, O. (2019, December).
Acetaminophen poisoning-induced heart injury: A case-based review. Daru : journal of Faculty of
Pharmacy, Tehran University of Medical Sciences.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895290/#:~:text=Toxic%20effects%20of%20ace
taminophen%20in,failure%20as%20well%20%5B38%5D
O’Malley, G. F., & O’Malley, R. (2023, June 21). Acetaminophen poisoning - injuries; poisoning. Merck
Manuals Professional Edition. https://www.merckmanuals.com/en-ca/professional/injuries-
poisoning/poisoning/acetaminophen-poisoning#v8343420
Susan E Farrell, M. (2023, June 14). Acetaminophen toxicity treatment & management. Approach
Considerations, Gastric Decontamination, Oral N-Acetylcysteine.
https://emedicine.medscape.com/article/820200-
treatment#:~:text=As%20with%20any%20ingestion%2C%20assessing,within%201%20hour%20of
%20ingestion