Syllabus

Course name Health and Defence II

(Microbiology & Pharmacology & Immunology) VI semester
Lecturer surname, first Mzia Tsiklauri PhD, invited lecturer
name Phone: 577 41 30 50; e-mail: m.tsiklauri3@seu.edu.ge
Giorgi Gurgenidze- invited lecturer
Phone: 599 18 32 16; email: g.gurgenidze@seu.edu.ge
Tinatin Gognadze, Invited lecturer
Phone: 599414763; email: tikuna_gognadze@yahoo.com

Consultation days are fixed weekly according to the timetable, also online at the
specified address.
Course status Mandatory
ECTS credits 5 ECTS (Mirobiology – 2 credits, Immunology – 2 credits, pharmacology – 1 credits)
125 hours
Microbiology
Lecture – 15 hrs.
Practical Training – 15 hrs.

Immunology
Lecture – 10 hrs.
Practical Training – 10 hrs.

Students’ workload
Pharmacology
Lecture – 5 hrs.
Practical Training – 5 hrs.

Midterm exam- 1 hr.

Final exam- 2 hrs.
Contact hrs. - 63
Individual work – 62 hrs.
Course Prerequisite Health and Defence I (Microbiology & Pharmacology)
Course Goal(s) The aim of the course is to teah students the microbial and viral diseases of different
systems, of body, fungal and basic parasitic diseases, their pathogenesis, immunological
responses, treatment of the diseases caused by these agents.
Teaching-learning forms The lecture - systemic and consecutive transfer of course related topics by
verbal presentation, explaining topics or several issues. The process is
interactive when dialogue is used and students are involved in the discussion of
theoretical topics. The lectures are supported by presentations. Visual aids (eg.:
1
 atlases, posters, charts, etc.) and computer technologies are used during the
lecture. The basic aim of the lecture is to help students to comprehend the
major notions of the subject taught which implies creative and active
perception of the material. Attention should be paid to basic concepts,
definitions, designations, assumptions. A critical analysis of main issues, facts
and ideas is necessary. The lecture should provide for scientific and logically
consistent cognition of basic concepts. Moreover, facts, examples, schemes,
drafts, experiments, and other visual aids should help explain the idea conveyed
by the lecture.
Seminar – in-depth study of the topics delivered at the lecture. A student or a
group of students search for the additional information, process it, prepares the
presentation. At the seminar students present reports, discuss the topics, make
conclusions. The lecturer coordinates and directs the discussion.
Lab. – working with microscopes in laboratory, viewing microscopic
specimens, identification of agents causing pathologies on the specimens.

Quiz – written test – checking the assessment of specific cases within the
studied material and skills of integration of knowledge.
OSPE – Objective Structured Practical Examination is used as an objective
instrument for assessment of laboratory exercises in preclinical sciences.
Students are evaluating photomicrographs/microscopic specimens and identify
the pathological agent.
Learning Outcomes
General Competencies
Knowledge and Understanding:
A student will be able to:
• Deep and Systemic knowledge of the field area and its critical analysis that covers some modern
achievements of the sphere, provides basis for the development of new ideas.
Skills:
• Use modern methods and approaches while solving complicated problems in multidisciplinary
environment.
• Analyze complex information, synthesize it, evaluate and make decisions.
Responsibility and Autonomy:
• Manage the multidisciplinary environment and adapt by using new strategic approaches.

Field-Specific Knowledge (Biomedical Sciences)

A student will:
• Describe the microbial and viral diseases of different systems of body, its pathogenesis. (Quiz)
• Describe the tumor viruses and their pathogenesis. (Quiz)
• Determine the immunological response to microbial and virus diseases. (Quiz)
• Determine the immunological response in case of cancer and transplantation. (Quiz)
• Identify the microbial agents and determine the pathogenesis caused by them. (OSPE)
2
• Determine the drug treatment of different systems of body in case of microbial, viral, fungal and parasitic
diseases. (Case Study)
•
Field-Specific Competencies
9. The use of knowledge, skills and principles based on evidence.
• Analyze the published literature, case studies, provide with the analysis and make conclusions. (Case
Study)

13. Professionalism
Perform capacity for analysis and synthesis. (OSPE, Case Study)
Assessment system

University assessment allows five positive and two negative assessments.

1. The Grading system shall allow:
a) (A) Excellent –91% and over of maximum grade;
b) (B) Very good –81-90% of maximum grade;
c) (C) Good – 71-80% of maximum grade;
d) (D) Satisfactory – 61-70% of maximum grade;
e) (E) Acceptable –51–60% of maximum grade;
2. Two types of negative grades:
a) (FX) Fail – 41-50% of maximum grade, meaning that a professional student requires some more work before
passing and is given a chance to sit an additional examination after independent work;
b) (F) Fail –40% and less of maximum grade, meaning that the work of a professional student is not acceptable and
he/she has to study the subject anew.
In the case of FX assessment, the student can set for the make-up exam no less than 5 days after the announcement
of the examination results.

The minimum score for passing the midterm and final exams is 50% of the maximum score. The same applies to
the integrated course modules. In each module, the student must score 50% of the points assigned to each module.
If a student does not score the required points in a course or one or two modules of an integrated course, they are
eligible to take the makeup exam.

The minimum score for admission to the final exam is 50% of the sum of ongoing and midterm assessments.

If a student fails to pass the make-up exam, he/she will study the course / the whole integrated course (all modules)
again.

In the case of failure of the make-up exam, a student shall study the course/integrated course again with all its
modules.
ASSESSMENT FORMS, COMPONENTS, METHODS AND CRITERIA

Interim evaluation Final exam evaluation Final evaluation

Activity 40 points Midterm Exam 20 Final Exam 40 points 100 points

points

3
 Quiz– 40 (20x2) points Text – 20 points Test – 40 points

Methods of assessment
Activity
Quiz – is held 2 times, each quiz consists of 2 open questions (8 points); 2 Case
studies (6 points) and OSPE – 2 microscopic specimens (6 points), total – 20
points for each quiz.

Rubric for open questions:

4 points: the answer is complete, precise, the explanation is exhaustive, the
terminology is correct, the student shows thorough and in-depth knowledge of
the textbooks and additional references.
3 points: the answer is not complete; the explanation is not exhaustive and there
are some errors.
2 points: the answer is not complete; the terminology is not correct; doesn’t
show the comprehensive knowledge of the topic; doesn’t show the knowledge
of textbooks and additional references.
1 point - the answer is not complete; the terminology is not relevant; answers
are incorrect; information provided is not coherent; fundamental errors are
observed.
0 point – the answer is not provided or is not correct.

Rubric for OSPE

Identifies the agent in the specimen – 1 point
Identifies the pathology that causes the agent – 1 point
Determines the outcome of pathological process – 1 point

Rubric for Case Study

Identifies the relevant drug for the treatment the case – 1 point
Knows the mechanism of action of the drug – 1 point
Knows the side effects/compatibility with other drugs – 1 point
Midterm Exam Test – 20 points. It consists of 2 theoretical topics (6 points) and 16 multiple
choice questions (8 points), two specimens (6 points)

Rubric for the assessment of theoretical topics:

3points - The student is well prepared, his/her knowledge of the topic is
exhaustive; answers to the questions are comprehensive, correct and provided
with the reasoning; the student understand and has thorough knowledge of the
topic.

4
 2 points - The student is prepared, hastheoretical knowledge of the topic;
answers to the questions are not thoroughly supported by the reasoning; the
student has no thorough understanding of the topic.
1 point – The student’s knowledge is poor, answers to the questions are not
thoroughly supported by the reasoning; the student has no understanding of
the topic.
0 point - The student is not prepared, doesn’t know the topic; his/her answers
are incorrect.

Rubric for the assessment of MCQs:

Each correctly pointed answer earns 0.5 point.
Each incorrectly pointed answer earns 0 point.

OSPE – evaluation of 2 microscopic specimens, total – 6 points

Rubric:
Identifies the agent in the specimen – 1 point
Identifies the pathology that causes the agent – 1 point
Determines the outcome of pathological process – 1 point
Final Exam Test – 40 points.
It consists of 4 open questions (12 points) and 32 multiple choice questions (16
points), 4 specimens.
Rubric for the assessment of open questions:
3 points - The student is well prepared, his/her knowledge of the topic is
exhaustive; answers to the questions are comprehensive, correct and provided
with the reasoning; the student understand and has thorough knowledge of the
topic.
2 points - The student is prepared, hastheoretical knowledge of the topic;
answers to the questions are not thoroughly supported by the reasoning; the
student has no thorough understanding of the topic.
1 point – The student’s knowledge is poor, answers to the questions are not
thoroughly supported by the reasoning; the student has no understanding of
the topic.
0 point - The student is not prepared, doesn’t know the topic; his/her answers
are incorrect.

Rubric for the assessment of MCQs:

Each correctly pointed answer earns 0.5 point.
Each incorrectly pointed answer earns 0 point.

OSPE – evaluation of 4 microscopic specimens, total – 12 points

5
 Rubric:
Identifies the agent in the specimen – 1 point
Identifies the pathology that causes the agent – 1 point
Determines the outcome of pathological process – 1 point
Textbook and course materials
Required literature 1. Microbiology: An Introduction, 12th Ed,Gerard J. Tortora, Berdell R. Funke,
Cristine L. Case, 2016, Pearson
2. Basic and Clinical Pharmacology, Bertram G. Katzung, Susan B. Masters, Anthony
J. Trevor, 2017, The McGraw-Hill Companies, Inc
3. Levinson W. Review of Medical Microbiology and Immunology.14th Edition. 2018
г.
Additional literature 4. Quick Compendium of Clinical Pathology, 4th edition, Daniel D. Mais, 2018,
American Society for Clinical Pathology
5. Lippincott Illustrated Review: Pharmacology, Karen Whalen, 2018, Wolters Kluwer

Course content

Study Teaching-learning hours Topic

week methods
I 1 Microbiology
Lecture 2 Viruses, viroids, and prions. General characteristics of viruses.
Practical Training Viral structure. Taxonomy of viruses. Isolation, cultivation, and
identification of viruses. DNA viruses. RNA viruses Viral
multiplication. Viruses and cancer. Latent viral infections.
Persistent viral infections. Prions.

Pharmacology
Antiviral agents. Antiretroviral agents. Agents to treat herpes
simplex virus (hsv) and varicella-zoster virus (vzv) infections.
Agents to treat cytomegalovirus (cmv) infections; antiretroviral
agents.
II 1 Microbiology
Lecture 2 Microbial diseases of the digestive system. Normal microbiota of
Practical Training the digestive system.
Bacterial diseases of the mouth. Dental caries (tooth decay).
Periodontal disease.
Bacterial diseases of the lower digestive system.

Pharmacology
Drugs used in acid-peptic diseases. Antacids. H2-receptor
antagonists. Proton-pump inhibitors. Mucosal protective agents.
Sucralfate. Prostaglandin analogs. Drugs stimulating
gastrointestinal motility. Cholinomimetic agents. Macrolides.
6
 Antidiarrheal agents. Antispasmodics. Drugs used to treat
inflammatory bowel disease. necrosis factor therapy.
III 1 Microbiology
Lecture 2 Principles of disease and epidemiology. Pathology, infection, and
Practical Training disease. The etiology of infectious diseases. Classifying infectious
diseases. The spread of infection. Nosocomial (hospital-acquired)
infections. Emerging infectious diseases. Epidemiology microbial
mechanisms of pathogenicity. Pathogenic properties of bacterial
cells. Pathogenic properties of viruses. Pathogenic properties of
fungi, protozoa, helminths, and algae. Portals of exit

Pharmacology
Antiviral agents. Anti-hepatic agents. Treatment of hepatitis b
virus infection. Treatment of hepatitis c infection. Anti-influenza
IV 1 Microbiology
Lecture 2 Bacterial diseases digestive system. Typhoid fever. Cholera.
Practical Training Noncholera vibrios. Escherichia coli gastroenteritis.
Campylobacter gastroenteritis. Helicobacter peptic ulcer disease.
Yersinia gastroenteritis. Clostridium peifrjngens gastroenteritis.
Clostridium difficile-associated diarrhea. Bacillus cereus
gastroenteritis

Immunology
Introduction. Basic elements of the immune system. Natural and
acquired immunity. Nonspecific defense mechanisms: physical
barriers. Phagocytosis, complement and inflammation. Basic and
characteristic elements of the immune system: specificity,
diversity, memory, autoregulation and tolerance.
V 1 Microbiology
Lecture 2 Fungal diseases of the digestive system. Ergot poisoning.
Practical Training Aflatoxin poisoning.
Protozoan diseases of the digestive system.

Pharmacology
Basic and clinical pharmacology of chemotherapy of helminthic
infections.
VI Lecture 1 Microbiology
Practical Training 2 Viral diseases of the digestive system. Viruses causing
gastroenteritis: picornaviruses (enterovirus and rhinovirus
groups). Polioviruses. Coxsackieviruses. Other enteroviruses.
Rhinoviruses. Parechovirus group. Foot-and-mouth disease.
Quiz
Immunology

7
 The immune response. Humoral response. Cellular immunity.
Clonal selection. Cell cooperation. Effector mechanisms. Cellular
bases of Immunity
VII Lecture 1 Microbiology
Practical Training 2 Hepatitis viruses. Properties of hepatitis viruses. Hepatitis type
A. Hepatitis type B. Hepatitis type C. Hepatitis type D (delta
hepatitis). Hepatitis type E. Hepatitis virus infections in humans.
Virus–host interactions.

Immunology
Primary and secondary lymphoid organs and tissues. Thymus.
Spleen. Monocytes/macrophages. Granulocytes: neutrophils,
eosinophils and basophils. Dendritic cells and other accessory
cells.
Midterm 1

VIII Lecture 1 Microbiology

Practical Training 2 Herpesviruses. Properties of herpesviruses. Classification.
Herpesvirus infections in humans. Varicella. Zoster virus herpes
simplex viruses. Cytomegalovirus. Epstein. Barr virus. Human
herpesvirus. Herpes b virus. Paramyxoviruses and rubella virus.
Rabies.

Immunology
Immune system molecules. Antigens. Immunogens and antigens.
Haptens. Immunogenicity and antigenicity. Determining factors
of immunogenicity. Immunoglobulins. Structure, types and
functions. Major Histocompatibility Complex (MHC). Class I and
II MHC molecules.
IX Lecture 1 Microbiology
Practical Training 2 Human cancer viruses. General features of viral carcinogenesis.
Retroviruses. Replication of retroviruses. Human retroviruses.
Cellular oncogenes. DNA tumor viruses. Tumor suppressor genes.
Polyomaviruses. Classification. Papillomaviruses. Classification.
Adenoviruses. Herpesviruses. Poxviruses.

Immunology
Regulation of the immune response
Development and maturation. Mechanisms of antigen
presentation. Antigens and superantigens. Antigen-presenter
cells. Processed antigen bond with class I and II MHC molecules.
Activation macrophages. Accessory molecules. Complement.

8
 Cytosines. General characteristics. Classification of Th1 and Th2
populations according to cytosine production.
X Lecture 1 Microbiology
Practical Training 2 Viral diseases of the respiratory system.
Viral agents causing acute respiratory infections: Viral
pneumonia.
Fungal diseases of the lower respiratory system.

Pharmacology
Special aspects of perinatal & pediatric pharmacology. Drug
therapy in pregnancy. Drug therapy in infants & children.
Pediatric dosage forms & compliance. Drug use during lactation.
Pediatric drug dosage.
XI Lecture 1 Microbiology
Practical Training 2 Protozoan disease of the reproductive systems .trichomoniasis
.the torch panel of tests

Immunology
Regulation of the immune response. Homeostasis of the
immune system. Antigen elimination. Tolerance. Suppressor
cells. Idiotypic network. Antibody feedback.
Immunological response to infections and parasites.
Extracellular signals. Intracellular bacteria. Fungus. Virus.
Parasites. Immunodeficiencies. Primary immunodeficiencies.
Characteristics of the HIV virus. Immunology of HIV infection.
AIDS
XII Lecture 1 Microbiology
Practical Training 2 Viral diseases of the reproductive system. Genital herpes .genital
warts
Fungal disease of the reproductive systems candidiasis.
Quiz
Immunology
Autoimmunity. Concepts of tolerance and autoimmunity.
Predisposition factors. Activation mechanisms of the autoimmune
response. Pathogeny of antibodies. Organ-specific and systemic
autoimmune diseases
XIII Lecture 1 Microbiology
Practical Training 2 Aids and lentiviruses. Properties of lentiviruses. Classification.
Hiv infections in humans.

Immunology
Transplant immunology. Immunointervention. Transplant laws.
Allotransplantation and xenotransplantation. Immunological

9
 response. Pathogeny of antibodies. Organ-specific and systemic
autoimmune diseases
XIV Lecture 1 Microbiology
Practical Training 2 Blood & tissue protozoa. Plasmodium. Toxoplasma.
Pneumocystis. Trypanosoma. Leishmania

Immunology
Tumor immunology. Tumor antigens. Immunological response to
tumors. Immunodiagnosis. Immunotherapy.

XV Lecture 1 Microbiology
Practical Training 2 Arthropod-borne and rodent-borne viral diseases. Human
arbovirus infections.

Immunology
Arbovirus host–vector transmission cycles. Yellow fever. Dengue.
Bunyavirus encephalitis. Sandfly fever. Rift valley fever. Colorado
tick fever. Rodent-borne hemorrhagic fevers. Bunyavirus
diseases. Arenavirus diseases. Filovirus diseases. Reoviruses.
XVI-XVII Final exam
XVIII -XIX Make-up exam

10