This document contains two family case studies with genetic questions. For the first case of a rare skin disease: the inheritance is likely autosomal recessive; the first generation would be carriers (heterozygous); generations III individuals 9 and 10 could be homozygous affected, carriers, or normal; and there is a 50% chance the offspring would have the disease. For the second case of hemophilia: the inheritance is likely X-linked recessive; the first generation would be a carrier female and normal male; generation II individuals 5 and 1 could be a carrier female and normal male; and the son of generation III individual 2 has a 50% chance of being affected.
This document contains two family case studies with genetic questions. For the first case of a rare skin disease: the inheritance is likely autosomal recessive; the first generation would be carriers (heterozygous); generations III individuals 9 and 10 could be homozygous affected, carriers, or normal; and there is a 50% chance the offspring would have the disease. For the second case of hemophilia: the inheritance is likely X-linked recessive; the first generation would be a carrier female and normal male; generation II individuals 5 and 1 could be a carrier female and normal male; and the son of generation III individual 2 has a 50% chance of being affected.
This document contains two family case studies with genetic questions. For the first case of a rare skin disease: the inheritance is likely autosomal recessive; the first generation would be carriers (heterozygous); generations III individuals 9 and 10 could be homozygous affected, carriers, or normal; and there is a 50% chance the offspring would have the disease. For the second case of hemophilia: the inheritance is likely X-linked recessive; the first generation would be a carrier female and normal male; generation II individuals 5 and 1 could be a carrier female and normal male; and the son of generation III individual 2 has a 50% chance of being affected.
1. Identify the type of inheritance. Explain your answer. 2. Supposed this is a rare skin disease. What are the genotypes of 1 and 2 from the very first generation? 3. What are the genotypes of 9 and 10 from the IV generation? 4. What is the possibility that the offspring will have the rare disease if number 1 from generation III will marry a man with the disease?
B. FAMILY CASE 2 - HEMOPHILIA
1. Identify the type of inheritance. Explain your answer.
2. Supposed this is a pedigree of a hemophiliac family. What are the genotypes of 1 and 2 from the very first generation? 3. What are the genotypes of 5 and 1 from the generation II? 4. What are the chances that the son of 2 from generation III will be hemophiliac?