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DEEPAK SIR ANATOMY Final
DEEPAK SIR ANATOMY Final
DEEPAK SIR ANATOMY Final
Deepak Dhakal
Cell, Tissue & Cavities
Human Cell
o Cell is the basic unit, structural unit, functional unit, smallest unit of the
body.
o Cell + Cell – Tissue + Tissue- Organs + Organs - System + System = A
complete body.
o Cell is the Building block of body.
o Robert Hook – 1665 AD – Founder of cell.
o Cytology – Study of cell.
o Histology – Study of tissue
o Smallest cell of body – Spermatozoa – 2.5 – 3.5 um- Male Gametes
o Largest Cell of the body – Ovum – 18 – 28 mm
o Longest cell – Neurons
o Human body – start from Zygote – 23 Pairs or 46 chromosome
o Zygote – Spermatozoa (23) + Ovum (23)= Zygote (46)
o 21st Pairs + 1 extra X chromosome = 47 – Trisomy 21 – Down Syndrome
– Most common chromosomal defect in fetus
o Delayed Pregnancy after 35 yrs / Hormonal Therapy / Radiation
Exposure high – Down Syndrome
o
Cell has – 3 Parts:-
1. Cell Membrane 2. Cytoplasm 3. Nucleus
1. Cell Membrane- Immunological Identify.
2. Cytoplasm:- It contains 3 parts :-
Liquid Parts- Cytoplasmic Matrix eg. Intra Cellular Fluid eg. Potassium
High K+
Non Living Parts- Cytoplasmic Inclusions eg. Vacuole, Fat droplets
Living Parts:- Cytoplasmic Organelles
1. Mitochondria
Power House of the cell. It produce the energy i.e called ATP
Adenosine Try phosphate (ATP) – Energy
Carbondioxide Production – Co2
Glucose Utilization
Cellular Respiration complete
a. Ribosome:- Protein Factory of Cell
b. Lysosome:- Suicide bag of the cell
c. ER – Endoskeleton System of Cell.- 2 types – Transportation
Smooth ER
Rough ER
3. Nucleus: - Excepts RBC
o Largest Parts of cell. Important parts of cell
o Brain of cell. Control all the activities of cell.
o Nucleus contains 23 pairs chromosome.
o 22 – Pairs – Autosome or Somatic Chromosome – Mitosis
o 1 – Pairs – Sex Chromosome – Meosis CD
o Chromosome – DNA - Gene – Genetic Character Transfer – Parents to
Children’s
o Gene is the smallest or functional unit of chromosomes.
o DNA (Gene)- Genetic Characters transfer to the fetus.
o 23 Pairs – 22 Pairs – Mitosis Cell Division- Autosome
o 1 Pairs – Sex Chromosome – Meosis Cell Division
o Karyokinesis – Nucleus division process
o Cytokinesis – Cytoplasm division process
Q. Which blood cells Abscent nucleus?
a. RBC
b. WBC
c. Platelets
d. All of the above
ET - two types
1. SET- Squamous/Cuboidal/Ciliated & Columnar
2. CET – Stratified / Transitional
Startified – Keratinized & Non Keratinized
Connective Tissue
o This is the most abundant tissue in body. It takes the 25 – 30% weight
of body.
o It is hardest tissue or defensive tissue or protective tissue of the body.
It is classified into three groups:- Lose CT, Dense CT & Specialized CT
1. Connective tissue Proper
2. Fluid CT eg. Blood & Lymph – Specialized CT
3. Skeletal CT eg. Bone & Cartilage
Cavities
1. It is a hollow space of the body, where the vital organs are placed.
(शर रको खो ो भाग जाँहा मह वपुण अगह सुर ीत पमा बसेको हु छन।)
2. It can be classified into groups:-
A. Ventral Cavity:- Front aspect of human body ( Thoracic & Abdominal-
pelvic cavity)
B. Dorsal Cavity:- Posterior portion of body (Cranial & Vertebral Canal)
Q.10. The cavity that is made by muscle and bony framework and looks like
a cage, it is ….
a. Cranial cavity
b. Thoracic cavity
b. Abdominal Cavity
d. Pelvic cavity
Digestive System
It is also called alimentary system. It is start from mouth to anus.
It made a track between through mouth to anus i.e called Alimentary
Canal.
The total length of alimentary tract is 8 – 10 meter.
Digestive system is made by 4 layers:-
Serosa or Adventitia
Muscular Layer
Submucosal Layer
Mucosal Layer – Goblet cells – Columnar Epithelium
The inner lining of digestive system is made by columnar epithelium.
The main functions of digestive system are
o Ingestion
o Propulsion- Push of food
o Digestion
o Assimilation – Mix
o Absorption
o Elimination.
Ingestion ……Digestion……Absorption……Elimination
Digestive organs are classified into two groups:-
1. The main Organs:-
o Mouth or Oral Cavity
o Pharynx
o Esophagus
o Stomach
o Small Intestine
o Large Intestine
o Rectum & Anus
2. The Accessory Organs:-
o Salivary Glands
o Pancrease
o Liver
o Gall Bladder & Its duct
Mouth or Oral Cavity
It is also called buccal cavity or Oral Cavity.
It contains tongue & teeth
Tongue
It is a voluntary muscular organ. It is also called Lingue.
It is attached by a bone i.e. called hyoid bone. This bone is also known
as a unsocial or horse shoe shaped bone.
Blood supply is by lingual artery & nerve supply is by the lingual nerve.
Tongue has 3 types taste buds (Papillae):-
o Valate- Bitter Taste – Largest size
o Filliform- Sour Taste – Smallest size
o Fungiform- Sweat & salty – Umami taste – Delicious food
5 types taste can be identify by tongue:-
o Bitter – By Valate
o Sour – By Filliform
o Sweat
o Salty
o Umami taste – Delicious Food
Most sensitive taste is bitter taste & sensitive taste buds is Valate taste
buds.
Auegusia is the loss of taste sensation (Glossopharyngeal Nerve- 9 th
cranial
Glossitis is the infections & inflammation of tongue.
Coated tongue – Typhoid - White patch
Breast feeding – tongue – upthus ulcer – Fungal infection – GV paint
Teeth
It is tool of mastication.
The Masseter, Pterigoid & Temporalis are the muscle for the
mastication.
Hardest tissue is dentine & substance is enamel.
Pulp Cavity is found in the teeth (Pulpits).
Periodontitis is the infection & Inflammation of teeth.
Teeth can be classified by two ways:-
o Eruption Based (Primary & Secondary Teeth)
Structure Based (Incisor, Canine, Pre-molar & Molar)
Difference between primary & secondary teeth:-
SN Primary Teeth Secondary Teeth
1 Total 10 + 10 = 20 16 + 16 = 32
2. Start from 6M & Complete in Start at 6 Y & Complete in 24th Y
24M
3. Formula - 2102 Formula - 2123
4. 1st Teeth is – Lower Central Last teeth is – 3rd Molars
Incisors
5. Abscent – Pre Molars Present Pre Molars
7. Temporary teeth Permanent teeth
8. Deciduas or Milk teeth Adult teeth
Pharynx:-
It is a common passage for both respiratory & digestive system.
12 – 14 cm long.
Extend from base of skull to C6.
It has 3 Parts:- Nasopharynx, Oropharynx & Laryngopharynx.
The Real Common Passage is Oropharynx.
Eustachian tube connects middle ear to Nasopharynx. Its 4 cm long.
Pharynx contains 2 types of tonsils:- Pharyngeal (Adenoids) & Palatine
tonsils
Quincy is the pus collection in the tonsils.
Esophagus:-
It is narrowest part (2cm-Diameter) of digestive system.
Its length is about 25 cm.
Inferior thyroid artery supply pure blood to the esophagus.
It has three parts:-
o Cervical
o Thoracic
o Abdominal
It is also called food pipe or gullet.
Diaphragm pierces to diaphragm at the level of T10.
GERD – Gastro Esophageal Reflux disease
Hiatus Hernia – Junction between esophagus & stomach
Stomach:-
It is widest part of digestive system. Dilatable organ
Gastric Artery or Coealic Artery – Blood Supply.
Its length is about 25 cm.
It has 3 parts:-
o Fundus
o Body
o Pyloric Antrum
2 Valve – Sphincters – Cardiac & Pyloric sphincters
It is ‘J’ shaped organ.
The inner layer of stomach contains gastric glands.
Gastric glands secrete a fluid i.e. called Gastric Juice.
PH Value of gastric juice is 1.5 – 3.5. It is produced 1.2 -1.5 lit/Day.
Gastric Glands contains following cell:-
Parietal Cell – Hcl & Intrinsic factors
It produced hydrochloric acid (hcl) & intrinsic factors.
Peptic Cell – Chief Cell – Pepsinogen/ Rennin
It is also called Chief cell. It secretes Pepsinogen & Rennin.
Rennin helps to digestion of milk & milk products.
Renin- Kidney – Blood Pressure
Mucus Cell eg. Produce Mucus
Intrinsic Factors – B12 Absorption – Lack of intrinsic – Low level of b12 in
blood – Iron/Folic acid/B12 – Hemoglobin – Anemia – Pernicious
Small Intestine
It is longest part of digestive system. Its length is about 5.25 meter. 5
meter
It is the place where complete digestion & absorption is takes place.
It contains solitary glands.- wall of Small Intestine
Celiac trunk & superior mesenteric artery supplied the pure blood to
the small intestine. – ANS (Nerve Supply)
Enteritis is the infection & Inflammation of Small Intestine.
Salmonella – Ileum – Payers Patches – Fever – Typhoid – Enteric Fever
Intestinal Glands are found in intestine. It secretes intestinal juice
(Succus Entericus).
Intestinal Juice also known as a -----Succus Entericus
Composition of Intestinal Juice
o Amount – 1.8 – 2.5 lit /Day
o pH value - 7.5 – 8
o Water – 98.5 %
o Solid Part – 0.5 %
o Enzyme :- Peptidase¸ Saccharase¸ Maltase¸ Lactase¸ Sucrase and Lipase
etc
It has three parts:- Duodenum, Jejunum & Ileum
Duodenum
o It is about 25 cm long.
o It is C- Shaped organs.
o It has Brunner’s Glands.
o Ampulla of Vater opens into duodenum. Sphincter of Oddi controls it.
o Iron/Vit C are absorbed from duodenum. Fat-soluble Vitamin
absorption.
Jejunum
o It is about 2 meter long.
o Most of the villi (Unit of Food Absorption) are present in jejunum.
o Carbohydrate & Protein are mostly absorbed through Villi.
o Fat & Fat soluble vitamins are absorbed through lacteals (Lymphatic
Capillary).
o Most Important unit for food absorption …Villi
Ileum
o It is about 3 meter long.
o It is longest part of small intestine.
o It contains 20 – 30 lymphatic parts i.e. called Payer’s Patches.
o Ileum is most commonly affected during typhoid fever (Payer’s
Patches).- Ileum – Enteric Fever – Intestinal perforation – Complication
Salivary Glands
They are accessory organ of digestive system. It is 3 pairs. They all have
duct so they are called exocrine glands.
1. Parotid Glands:- It is open at 2nd molar teeth with Stenson’s duct. ……SP
Stenson’s – Parotid
2. Sub Mandibular Glands:- It is open with Wharton’s Duct (70% Saliva
Production)
3. Sub Lingual Glands
o Parotitis is the infection & inflammation of parotid glands. It is mostly
due to mumps virus – salivary – Parotid glands
o Sialadenitis:-Infection & Inflammation of salivary glands.
o Sialalithiosis:- Stone in the salivary glands & duct.
o Mumps - Parotitis.
They Produces saliva:- 0.5 – 1.5 lit/day.
Compositions of Saliva:- IgA, Blood Clotting factors, Amylase (Ptyalin) –
Mouth Low chance
Water - 99 %
pH Value :- 6.5 – 7.5 (6.7)
Protein and Salts – 1%
Mucus – Makes Food Lubricants
Enzymes:-
Ptyalin (Amylase):- Start the digestion of Carbohydrate form mouth.
Fat digestions start from …..Duodenum or Small Intestine
Pancreas
It is mixed glands of human body.
It is about 12 – 15 cm long.
It has 4 parts:- Head, Neck, Body & Tail.
Head of Pancrease is covered by duodenum. So Pancrease is also
known as Romance of abdomen – Pancrease
Structure of Pancrease
It has 2 types of cell:- Exocrine Cell & Endocrine Cell.
Exocrine Cell:- 98% of total Parts – Pancreatic Juice
Endocrine Cell:- 2% of total parts (Islets of Langerhans)
Exocrine Cell secretes the pancreatic juice.
Composition of pancreatic juice:-
o Daily Production:- 1 – 2 lit/days
o Ph. Value :- Average 8
o It has:- Water, Cations, Anions, Digestive Enzyme (Amylase, Trypsin &
Chymotrypsin, Lipase)
Endocrine Cell (Islets of Langerhans) contains-
Beta Cell:- Insulin Production (Decrease the blood Glucose Level)
Alpha Cell:- Glucagon Production (Increase the blood glucose Level)
Delta Cell:- Somatostatin Production ( Balance the Insulin & Glucagon
Action)
Insulin – Reduce blood Glucose level
Glucagon – Increase blood glucose level
Somatostatin – Balance
Liver – Hepatic
Hepatic – also Called
Metabolic center of the body – Heat Productions
Largest Glands of the human body – Largest Visceral Organs
It is the hard working organ of body.
Fastest Regenerate Organs
Least – Low capacity of regeneration- Brain Cells
It has 4 lobe:-
Right Lobe
Left Lobe
Caudate
Quadrate
Physiologically – 2 Lobe Right – 90% & Left- 10%
Anatomically or Structurally – 4 Lobe
Weight - 1.2 – 2.2 kg (1500gm).
Smallest unit - Acinus.
Smallest cell - Hepatocytes.
Fastest regenerative organ - Liver
Macrophage - Kuffer’s Cell – Liver protective Cells
Fetus Life – Blood cell Production – Liver
Q. The blood cells are mainly produced in fetus life is…
a. Liver b. spleen c. Bone Marrow d. Lungs
1st Choice – Bone Marrow
Hemolysis – Spleen
Functions of Liver:-
Bile formation (500 – 1000 ml/Day)
Convert indirect bilirubine – Fat soluble into direct bilirubine – water
RBC – Rupture – Bilirubine – Fat Soluble (Unconjugated)- Indirect
Bilirubine…………..Water or Conjugated or Direct Bilirubine
Stool …..70%... Sterocobilinogen
Urine ….15 – 20% …….Urobilinogen (Amber Colour)
Detoxification of poison.
Metabolic of Drugs¸ alcohol and Food etc
Storage of Glycogen, Vitamin & Minerals etc
Plasma protein Production eg Albumin, Globulins, Fibrinogens etc
Blood clotting factors formation eg. Liver immature – Hemolysis – Vit K
injection
Heat production
Vitamin storage eg. Vit A (6-9 months), B12 (3-5 Yrs) , Vit K
Formation of non-essential amino acids
Digestion of Food
The process of digestion is start from mouth & ends at small intestine.
Digestion Process is complete by two ways:-
1. Mechanical Digestion:- Digestion By Teeth & Intestinal Movement
(Peristalsis Movement).
2. Chemical Digestion:- Digestion By the helps of Enzyme of digestive tract.
Digestion of Carbohydrate:-
Start :- Mouth by the Help of Salivary Amylase
Ends :- Small Intestine
Main Enzyme:- Salivary Amylase & Pancreatic Amylase , Saccharase
Smallest Unit:- Monosaccharide or Glucose
Main Source of Carbohydrate is Starch – 4 kcal/gm energy अ न
Indigestible Carbohydrate is Cellulose or Fiber Diet (Prevent
Constipation) 2 kcal/gm
Anemia – Gm
Bilirubin – mg
Digestion of Protein:-
Start :- Stomach by the help of Hcl and Pepsin
Ends :- Small Intestine
Main Enzyme:- Pepsin¸ Trypsin, Chymotrypsin & Peptidase.
Smallest unit:- Amino acids 4kcal/gm – Energy
Main source of Protein – Pulses गेढागुडी
Digestion of Fats:-
Start :- Small Intestine
Ends :- Small Intestine
Main Enzyme:- Lipase & Bile salts
Smallest Unit:- Glycerol or Fatty acids
9kcal/gm - Energy
Q.5. The digestion of milk and milk product by the help of…
a. Amylase Enzyme
b. Trypsin Enzyme
c. Rennins Enzyme
d. Lipase Enzyme
12 – 16 /minute – RR
Co2 high blood – blood Ph value – Acidic – Respiratory Acidosis
Co2 level low in blood – Alkaline – Respiratory Alkalosis
Q. In COPD ….
a. Hypercarbia……Blood Ph convert into acidic ……..Respiratory Acidosis
…..Blood PH …Low or High
b. Hypocarbia
Nose
Nose Supplied by 1st Cranial Nerve i.e. called Olfactory – Smell
Loss of smelling - Anosmia.
It contains Little’s area or Keisselbach’s plexus – Most Common site
Epistaxis.
Pharynx
It is common passage. 12 – 14 cm. 3 parts
Lungs
Major Organ of Respiratory System.
Alveoli are the smallest & functional unit of lungs.
Sputum is produced by Goblet Cell in the lining of respiratory organs.
Sputum is moved by cilia i.e. found in the lining of respiratory organs.-
Ciliated epithelium
Bronchial artery supplies the pure blood to the lungs.
The space between two lungs is called Mediastinum, where the heart is
placed safely.
Right Lungs is about 650 gm & Left Lungs is about 600 gm.
Q. Left lungs is small due to the…
Ans:- Due to the compression of heart
Surfactant factor is found in the lungs of new born. This helps to
stimulate the reparation process in new born.
D. Right Lungs has 3 lobes (Oblique & Horizontal Fissure) & Left Lungs
(Oblique Fissure) has 2 Lobes.
Inspiration …Diaphragm…Down
Intercostal …Out & Upwards
E. Lungs are covered by pleura. It has 2 layers:-
1. Visceral ….Inner
2. Parietal Layer – Outer
APGAR Score…..
1st & 5 minutes …….Golden Minutes of Baby
1st minute of life is golden minute for new born baby. 1 & 5minutes
Extra Supports need ….Decide within one minute of births
3. Nitrogen is also called pain killer gas.
4. The process of exchange of gas is by diffusion process. It means the
gases transfer from higher concentration to lower concentration.
Q. What is diffusion process……
Active Process
Passive Process
Transportation of Gas:-
Vital Capacity (VC):- This is main capacity of lungs. It is the sum of TV,
IRV & ERV. It is about 4600 ml.
Total Lungs Capacity (TLC):- It is sum of total of Vital capacity & Residual
Volume. It is about 5800 ml
Anatomical Dead Space:- This is the air volume, which is not participate
any process of lungs. It is about 150 ml.
Minet Ventilation:- This is the air volume that is taken by the lungs in
one minute. It is about 6 liter/ minute.
Air Volume taken by lungs in one minutes
12 X 500 ml = 6000 ml = 6lit /minutes
Unconscious – 6 – 8lit/minutes
12 – 15 minute
12 X 500 ml = 6000 ml = 6lit/minutes
12 – 20 normal
12 – 16 normal
12 – 15 normal
Types Of Respiration
.
External or Pulmonary Respiration:- The exchange of gas between
Skeletal System
Bone/Cartilage/Joints/Tendon/ Ligament
Bone – Strongest tissue/Connective tissue
20% - Water
Calcium 98% deposit in Bone…& Phosphorous deposit
3 types of Cells is required for the bone development….
1. Osteoblast – Bone Forming Cells हाड बनाउने कोष
2. Osteoclast- Shape / Safety – Macrophage of Bone
3. Osteocytes:- Mature Cell of bone
Bone are made from….
1. Cartilage – Cartilaginous Bone
2. Membrane – Membranous Bone
3. Tendon – Tendoneous Bone
Classification of Bone:-
1. Axial Skeleton – 80 – Skull, Vertebrae, Ribs & Sternum
2. Appendicular Skeleton- 126…. Upper Limbs, Lower Limbs,
Scapula & Clavicle, Pelvic Bone
Types of Bone:- 3 ways:-
1. Structure Based:- Spongy & Compact
2. Origin Based:- Cartilaginous/Membranous/Tendoneous
3. Size Based:- Long/Short/Irregular/Flat/Sesamoid
Q. Types of bone is…….. a. 2 b. 3 c. 4 d. 5
Axial Skeleton
80 Bones in axial
Skulls – 22 + Vertebrae 33 + Ribs – 24 + Sternum 1 = 80
Q. Axial skeleton is not included …….
a. Upper Limbs b. Vertebrae c. Skull d. Sternum
Skull Bone
22 Bone – 14 Facial & 8 Cranial Bone
Cranial Bone:-
Frontal - 1
Occipital – 1
Temporal – 2
Parietal – 2
Ethmoidal – 1
Sphenoidal – 1 = Bat Wings or Butterfly shaped Bone
Sinus Bone:- Frontal/Maxillary/Ethmoidal/Sphenoidal
Frontal sinus….Abscent in Newborns
Largest…Maxillary
Sutures
Fibrous Tissue …Connects Cranial Bone
Sutures Abscent ….Fontanels
1. Anterior Fontanels – 12 – 18 Months
2. Posterior Fontanels 2 – 3months
Types of sutures:-
1. Coronal Sutures:- Frontal & Parietal Connects
2. Sagittal Sutures:- Connects to Parietal Bone
3. Lamboidal sutures:- Parietal & Occipital Connects
4. Metopic Sutures:- 2 Frontal Bone
5. Frontal sutures:- Anterior Fontanels
Sagittal …2 Parietal
Coronal…F & P
Lamboidal….P & O
Facial Bone – 14
They All Are Irregular Bone.
Zygomatic/Maxilla/Nasal Bone/Palatine/Mandible/Vomer
Skull….
1. Total Bone ….22
2. Cranium – 8 & Facial 14 = 22 Bone
3. Movable Joints …..TMJ
4. Sinus Cavity …4
5. Sutures …..Fibrous Tissue …Connects to skull bone
6. Fontanels….2 major…Anterior …12 – 18 m…..
7. Sagittal sutures ……..2 parietal bone
8. Lamboidal Sutures….Parietal & Occipital
9. Coronal Sutures…Frontal & parietal
Q. Ribs/Sternum are…
a. Long Bone b. Flat Bone c. short Bone d. Irregular Bone
Q. Phalanges are….
a. Long b. short c. Flat d. irregular
4 Ribs ….Nipple….Breast Ribs …
th
Sternum
Flat Bone
Breast Bone
3 Parts…Manubrium/ Body/Xiphoid Process
1st Ribs …Manubrium
2 …10th …Body Connects
Xiphi sternum or Xiphoid Process
Bone Marrow aspiration …Sternum
Q. Which parts of bone not included in sternum…
a. Manubrium
b. Body
c. Neck
d. Xiphoid Process
Lower Limbs
30 X 2 = 60 Bones
3 parts divide ….
Thigh :- Femur Largest/Longest/Strongest- 18inch or 45 cm -
1
Leg:- Febula/Tibia/ Patella - 3
Foot:- Tarsal (7)/Metatarsal/Phalanges – 26
Largest Joints….Knee Joints (Hinge Joints)
Most Common Sprains……Ankle Joints
Knee Cap ……..Patella
Tibia …shin Bone
Most Common Fracture in Players ….Tibia (Muscle Coordination)
Pelvic Girdle
1. 2 Hip Bone / Innominate Bone /Basin Like Structure
2. Flat Bone
3. Each Hip Bone contains 3 parts …
Ilium
Ischium
Pelvis
4. Sacroiliac Joints – अधचल
5. Symphysis Pubis …अधचल
6. Male or Female …..After skeleton …Death
7. Bone Graft …Most Common Used …Pelvic Bone
Joints
Connection between 2 or more than 2 bone.
Joints can be connected by three ways…
1. Fibrous Tissue:- Fibrous Joints
2. Cartilage:- Cartilaginous Joints
3. Synovial Membrane:- Synovial Joints
Joints are three types:-
अचल जोन Fibrous Joints eg. Cranium/Teeth joints
अधचल जोन Cartilaginous Joints eg. Symphysis Pubis/Sacroiliac
Joints/Vertebrae/Acromioclavicular Joints
चल जोन Synovial Joints eg. Most of the free movable joints
Types of synovial Joints
1. Ball & Socket Joints eg. Shoulder/Hip Joints
2. Hinge Joints eg. Elbow/Knee Joints
3. Gliding Joints eg. Wrist/Ankle joints
4. Pivot Joints eg. Head & atlas joints
5. Chondyloid Joints eg. TMJ
6. Saddle Joints eg. Phalanges Joints
Bone to Bone Connection …….Ligaments
Bone to Muscle ….Tendon
Cartilage …three types …..Hyaline/Fibrous/Elastic
Large Amount of cartilage…Hyaline
Chondrocytes ….Cell of cartilage
3 Cells Bone….
Osteoblast….Bone Forming Cells
Osteoclast…..Macrophage of bone
Osteocytes ………..Matures cell of bone
Origin of Bone:-
1. Membrane
2. Cartilage
3. Tendon
Circulatory System
Also Called Cardiovascular System/ Transportation System.
Blood/Heart/Blood Vessels
William Harvey -1628. Blood Circulation- Founder
Heart Transplant- Dr. Christian Barnard 1967
Blood Group- Dr. Karls Landsteiner
Blood
Specialized Connective tissue
5lit/in Adult Body…..70ml/kg …..7- 8% of body weight.
2 Components …1. Plasma 2. Blood Cells
Plasma- Liquid Parts of Blood (55%)
90 % Water
Plasma Proteins (Liver)…Albumin ….Urine (Renal
failure)
Proteinuria + HTN+ Edema = Pre-Eclampsia
Blood Clotting Factors (Liver)
Blood Cells- Solid Parts of Blood (45%)
Blood Cells are produced by Red Bone Marrow (Spongy)
(Pluripotent Stem Cells – Stem cells)
3 Types Blood Cells ….Blood Corpuscles
S.N RBC WBC Platelets
1. Erythrocytes Leucocytes Thrombocytes
2. Oxygen Carry Defense/Fight Blood Clotting
3. 120 days- Life Span 8- 10 days 8 – 12 days
60 – 90 – Fetus
4. Longest Life Span Shortest Life Medium
Span
5. Nucleus Abscent Present Abscent
6. 7 micron size 14 – 16 micron 3.5 micron
7. Medium Largest Smallest
(Monocytes)
8. Erythrocytosis Leukocytosis Thrombocytosis
9. 45 – 55 lakh 4000 – 1.5 – 4
45 – 65 lakh/mm3 11000/mm3 lakh/mm3
Types of WBC……………5
WBC….Classified into 2 groups…..
1. Granulocytes:-
Neutrophils ….Acute Infection
Eosinophils……….Parasites effects (Albendazole)
Basophils …..allergic reaction
2. Agranulocytes
Lymphocytes
Monocytes
WBC – 10000 – Total Leucocytes Count – TLC
Differential Leucocytes Count – DLC
Heart
Busiest Organs of the body.
10 – 12 cm long & weight is about 300 gm.
250 – 300….275 gm
300 – 350 gm ……..325 gm
2nd Ribs – 6th Ribs & 1 prats in right & 2 prats in left side from
midline.
The opposite placement of heart is called….Dextrocardia
3 Layers …..Pericardium ……Myocardium…….Endocardium
Thick Layers……बा लो प …….Myocardium ……..Cardiac
Muscle
Most Important Layer…….Myocardium
Myocardium Failure/Necrotize…..Ischemic ….…..Myocardial
Infarction- MI (Heart Attack) ….Due to the blockage of
Coronary Artery.
Coronary Artery Blockage …High fat deposition in Coronary
Artery (Atherosclerosis)….Thrombosis……..Embolism
Parts भाग in Heart…1. Right Parts 2. Left Parts
Chamber कोठा in Herat ……..4
Right Atrium …Impure Blood
Right ventricle…Impure Blood
Left Atrium….Pure Blood
Left Ventricle…..Pure Blood
The pulmonary Valve is found in…..Right Ventricle
The Aortic Valve is found in…….Left ventricle
Tricuspid Valve is found in between……RA & RV
Bicuspid Valve is found in ….. … LA & LV (Mitral Valve)
4 valve inside the heart……1. Tricuspid 2. Bicuspid
3. Pulmonary Valve 4. Aortic Valve
Semilunar Valve ……….Pulmonary & Aortic Valve
1st sound…..Lub Sound …..is heard during the ….
1. Closer of Aortic & Pulmonary Valve
2. Closer of aortic & Tricuspid valve
3. Closer of Bicuspid & tricuspid valve
4. Closer of Aortic & Bicuspid Valve
2nd sound of heart …Dup Sound …Aortic & Pulmonary Valve Close
Extra than Lub & Dup Sound from heart……Murmur
Abnormal Heart sound is called….Murmur
Blood Supply ….Coronary Artery …………
1. Ascending Aorta
2. Arch of aorta
3. Descending Aorta
Impure Blood carry from heart…….Coronary Sinus (Superior
Venacava)
Nerve Supply….ANS (Sympathetic & parasympathetic)
Heart receive the blood during the phase of………..
1. During Contraction
2. During Relaxation
Cardiac Cycle:- Complete in 0.8 Second
Atrium Contraction- 0.1 second
Ventricle Contraction- 0.3 Second
Complete Relaxation – 0.4 Second
Heart Beat…..0.8s…...One Cycle….60 Second…..72/minutes
60 – 80/minutes -2nd best
60 – 100/ minutes. Normal Range – 3 rd
<60/minutes – Bradycardia
>100/minutes – Tachycardia
Conducting System of Heart …..SA Node (Right Atrium) ……Pace
Maker of the body.
AV Node…..Secondary Pace Maker
Stroke Volume & Cardiac Output
Blood Volume expels by heart in a single contraction…..70
ml….Stroke Volume
Stroke Volume X Heart Rate in One minute = Cardia Output
70 ml X 72 = 4999 ml (5lit/minutes)
In One contraction…..Blood Volume ….70 ml…..Stroke Volume
In one minutes ….Blood Volume….70 X 72 = 5lit/minutes = Cardiac
Output
Blood Vessels
3 types….
1. Artery……Blood caries away from heart….98%....Bright Red
2. Vein…..Blood carries towards the heart…..75%....Dark Red
3. Capillaries …..Exchange Between artery & vein…98% …Bright Red
Q. The capillaries is a part of…..3
a. artery- 98%
b. Vein ---75%
c. Both
d. None
The Layers of blood vessels are…… 3
The Layers of capillaries….1…..Made By single Layers
Layers….(Testes)
1. Tunica Adventitia
2. Tunica Media….Elastic Tissue …BP Determine
3. Tunica Intima
Blood Supply to vessels…..Vasovasorum
ANS – Nerve Supply
Differences between 3 Vessels
S.N Artery Vein Capillaries
1 Carry Blood From Carry Blood Exchange
Heart towards Heart
2 3 layers 3 layers Single layers
3 98% oxygen 75% Oxygen 98% Oxygen
4 No Valve Valve Present No valve
5 Most dangerous Bleeding Control Most Common
Bleeding itself
6. 12% Blood 60% Blood 5 – 10% Capillaries
Volume
7. Largest Largest
Artery…Aorta 45 cm Vein…Inf.
long Venacava
8. Longest artery Longest Vein
…aorta ……Great
Saphenous Vein
Arteritis Phlebitis…Infect
Pulsestile/Spurts Jets Continuous Oozing types
Bleeding
Nervous System
o Chief Controlling/Regulating System of the body.
o Body’s Activities Control/Regulation/Balance ………..
o 1. Nervous 2. Endocrine System (Hormone)
o Smallest Unit …Neurons …..Longest Cells/ Largest Cell in Male
o Neurons….Abscent cell division …..Brains Can’t transplant to
other.
o Liver Fastest Regenerative Organs…….
o Least regenerative organ…….Brains ……Spinal Cord
…..Paralysis
o Types Of Neurons…….3 types
1. Sensory…….Information share to the brains from outer side
of body…. Outer Parts……….towards …..Brains ………Afferent
2. Motor ……..Information share to outer parts of body from
brains…………Efferent Neurons
3. Mixed Neurons…..Both Actions
Sympathetic…………Thoracolumbar Outflow
Parasympathetic …. ……Craniosacral Outflow
CNS
It includes Brains & Spinal Cords.
They are covered by a layer i.e called meninges
Meninges has a 3 layers….
1. Duramater
2. Arachnoid mater
3. Pia Mater
Subdural Space
Subarachnoid Space……….CSF ………Intrathecal Route
CSF…..
Production……….Choroid Plexuses….0.5 ml/minute….720 ml/days
600 ml …Absorbed …..Arachnoid Villis
Remains Unabsorbed 120 ml…………CSF…Determine the intracranial
Pressure – ICP……5 – 15 mm of hg
CSF Ph Value……7.31 – 7.32 (7)
CSF Functions…
1. Shock Absorber or Cushions
2. Nutrition Provides to the brains tissue
3. CSF helps to moist ….Prevent dry
4. ICP Maintains
Brains
Chief Organs of Nervous System
80- 85% …water
2% of body weight …1000 – 1500 gm …1- 1.5 kg
5 Parts…….
1. Cerebrum…Largest Part of Brains
2. Cerebellum …Body balance & equilibrium
3. Mid Brains – Smallest Part of brains
4. Pons Varolii……….Pneumotoxic center
5. Medulla Oblongata
CNS…..
Brains & spinal Organs
They are covered by meninges….has 3 layers…
CSF…..Space between arachnoid & Pia mater
Brains
Chief organs of Nervous system
2% of body weight….1000 – 1500 gm – weight
80% Water
5 Parts…
1. Cerebrum…..Largest parts of Brain s
2. Cerebellum….Body Balance & equilibrium शर रको स तल
ु न
3. Mid Brains…..Smallest Parts
4. Pons Varolii मि तक सेतु eg. Pneumotoxic Center
5. Medulla Oblongata शस
ु ु ना शसक
Cerebrum ठुलो मि त क
Largest part of Brains.
Memory Power/Thinking Power/Intelligence……..
Has 2 Lobes……..These 2 lobes are connected by Corpus Callosum
1. Right Hemisphere
2. Left Hemisphere
Medulla Oblongata
2 cm long….
It has Vital center…..
1. Cardiac Center
2. Respiratory Center
3. Vasomotor Center
4. Reflux Center – Sneezing/Vomiting/Swallowing/Coughing Center
Cranial Nerves
12 Pairs or 24 – Cranial Nerves
1. Olfactory…….Smell…………Shortest Cranial Nerves
2. Optic ……….Vision
3. Oculomotor…..Eye Movement
4. Tracheal
5. Trigeminal……Largest Cranial Nerves
6. Abdscent
7. Facial
8. Vestibulochlear or auditory……….Hearing & Body balance
9. Glossopharyngeal…………..Taste
10. Vagus…….Longest Cranial Nerves ………Neurogenic Shock -
Vasovagal Syndrome
11. Accessory
12. Hypoglossal
Spinal Nerves
31 Pairs or 62 Nerve
Mixed Types – Both actions
Divided into 5 parts….
1. Cervical Nerves – 8 P
2. Thoracic Nerves – 12 P
3. Lumbar Nerves – 5 P
4. Sacral Nerves – 5
5. Coccygeal Nerves – 1 P
Sacral Nerves म ये १ जोडा लाई Sciatic Nerves (Thigh)…….…Longest
Nerves
Longest Cranial Nerves ….Vagus
Longest Nerves ………..Sciatic Nerves
Most suitable site for the IM inj……….Buttock (Outer & Upper Part)….
To prevent the injury of sciatic Nerves
Spinal Nerves …..Cauda Equine….
Cauda Equine………Lumbar + Sacral + Coccygeal = 11 Pairs
Eye
Orbital Cavity – Eye Placed
Weight – 7 gm
Diameter – 2.5 cm
Optic nerves – 2nd Cranial Nerves – sensory Neurons
Structure …There is 3 layers……
1. Outer Layer eg. Cornea & Sclera
2. Middle Layer eg. Iris, Ciliary Body & Choroid – Lens
3. Inner Layer eg. Retina
Outer Layer of Eye
Avascular Layer of eye.
It has 2 parts ………..1. Cornea 2. Sclera
Eye donation …..Cornea …..1/6th parts
Keratitis ……Inflammation of Cornea
Sclera….White portion of outer eye…….5/6th parts ……Jaundice seen
Transparent part of eye…. Cornea
Limbus ……Window of eye…..Junction point of cornea & Sclera
3. Lacrimal duct
4. Eye Lashes
5. Eye Lids
Ear
8th Cranial Nerves – Vestibulocochlear or Auditory Nerve –
Sensory
Autoscope…….….Instruments to watch the ear…….
Audiometer…Instruments to use the measurements of ear power.
3 Parts:-
1. External Ear
2. Middle Ear
3. Inner Ear
Skin
Largest Organs of body – Skin
Largest glands – Liver
Largest Visceral Organs – Liver
Weight – 4kg in Adult
Area – 1.5 – 2 sq.m2
2 layers…….
1. Epidermis….made by Keratin…..
Keratinized Epithelium …..Non Living Part of body
No Tuberculosis:- Hair/Nain/Epidermis – Keratin
No Blood Supply /Nerve Supply
5 layers:-
1. Stratum Cornium
2. Stratum Lucidium
3. Stratum Granulosum
4. Stratum Spinosum
5. Germinating Layer:-It contains Melanocytes Cells
…..Secrete melanin …Which responsible for skin colour
2. Dermis……
It has rich blood /Nerve supply
Arrector Pilli muscle found
Sweat & Sebaceous glands are found
Sweat Glands …Mostly ….Palm & Sole
Sebaceous Glands …Mostly ….face
Below the dermis …Fat layer Present…..Subcuneous Fat
…Hypodermis
Functions of skins…..
1. Protection Function
2. Secretion Function
3. Regulation of body temperature
4. Excretion
5. Sensation
6. Absorption
7. Vit D Formation
8. Bilirubine Convert
Sweat
A liquid that is secreted by sweat glands
Composition:-
99. 4% Water
0.2 % salts
0.4% Waste Products
The Infection of sweat glands…. Hidradenitis
Nail is started to form in fetus during the age of…….10 wks
Tip of Finger is blood supplied by……Digital Artery
Paronychia…infection of toenails or fingernails.
Nose
1st part of respiratory system
Ciliated epithelium
Olfactory Cells
1st Cranial Nerves ----Smell Information – Sensory
Little’s area or Keisselbach’s plexus- Most common site for
epistaxis
Tongue – Lingue
Voluntary Muscle
Lingual artery – Blood Supply
Lingual Nerve – Nerve Supply
3 types taste buds ….Valate/Filiform/Fungiform
Largest taste buds …..Valate……Bitter Taste
Smallest taste buds …Filiform………Sour taste
Most Number of taste buds …Filiform
Lowest number of taste buds …Valate
How many types of taste is founded by tongue…….5 types
Bitter/Sour/Sweat/Salty/Umami taste
Glossitis ….Infection of tongue
Tongue is attached with….Hyoid Bone …Unsocial
Bone/Horse shoe shaped bone……
Endocrine System अ त ाब णाल
They are glands. They are made by epithelial tissue. They
produce a liquid.
Glands are - 2 types….
1. Exocrine Glands…….…Having Duct…….Enzymes
2. Endocrine Glands …………Without Duct ……..Hormones
Exocrine (Duct)……….three types…….
1. Merocrine
2. Apocrine
3. Holocrine
Q. The exocrine glands are…….
A. 2 types b. 3 types c. 4 types d. 6 types
Endocrine Glands
They are ductless glands. They produce a fluid i.e called hormone
– Chemical Messengers
Protein & Cholesterol –Hormone
Types of endocrine glands……
1. Pituitary Glands
2. Pineal Glands
3. Thyroid Glands
4. Parathyroid Glands
5. Thymus Glands
6. Pancrease
7. Adrenal Glands
8. Testes
9. Ovaries
Pituitary Glands
Master Glands. It is attached with the hypothalamus.
Hypophyseal Fossa (Sphenoid Bone)
Hypothalamus release the hormone i.e
Inhibiting Hormone - IH
Releasing Hormone - RH
IH & RH control the activities of pituitary glands.
Pituitary Glands is regulated by….Hypothalamus - Head Master
GHRH is released by……
1. Pituitary Glands
2. Hypothalamus
Q. ACTHIH is released by……
1. Pituitary Glands
2. Hypothalamus
Pituitary glands divided into 3 parts ….
1. Anterior Lobe ……...Adenohypophysis
2. Posterior Lobe…….Neurohypophysis
3. Intermediate Lobe………Pars Intermedia
Small Pea shaped………केराउको ……500 mg
1. Anterior Lobe:- GH/TSH/ACTH/Prolactin/Gonadotrophic H
A. Growth Hormone – GH…………Skeletal Muscle/Bone Growth
B. Thyroid Stimulating Hormone - TSH ……..Thyroid Stimulate –
T3 & T4 Production
C. Adrenocorticotrophic Hormone - ACTH ……Adrenal Glands
D. Prolactin Hormone …………….Female Breast..
E. Gonadotrophic Hormone (FSH & LH)…..Testes & Ovaries
2. Posterior Lobe…..Oxytocin/ADH…
A. Oxytocin Hormone ……..Syntonic/Pitocin……..Breast & Uterus
B. Antidiuretic Hormone ADH/ Vasopressin…….Nephron/Blood
Vessels
3. Intermediate Lobe ……Melatonin Hormone
A. Melatonin Hormone…..Stop the reproductive organ
development…
Pineal Glands
It is located in Brain – Smallest glands/Smallest Organs
100 mg – weight …………7 – 10 mm size
Third Eye of brains…….
Night Activate………….Sleep Awake Cycle conduct
Melatonin Hormone Production……………Prevent the development of
growth of reproductive organs
Thyroid Glands
It is largest endocrine glands. It is about 25 gm weight.
It is butterfly shaped पत
ु ल आकारको
It has a C- Cells ……..Calcitonin Hormone production
Calcitonin is responsible for the reduction of calcium level in blood.
98% calcium in Bone. 2 % calcium in blood & Muscle
Q. High Production of calcitonin cause…..
1. Bone Strong
2. Osteoporosis
Q. High production of parathyroid hormone may cause……
1. Bone Strong
2. Bone Weak
Q. The osteoporosis is increase when the following hormone if high….
Oxytocin
GH
PTH
Calcitonin
Q. The chance of bone fracture is increase with the high production
of….
a. PTH
b. Calcitonin
Q. The chance of osteoporosis is high in menopausal stage due to
the…
a. PTH high
b. Calcitonin High
c. Ostrogen Imbalance
Thyroid Glands produced the following hormone………..
1. Calcitonin
2. Tri-iodothyronine (T3)
3. Thyroxin (T4)
They are released by the stimulation of TSH
TSH high ………..T3 & T4 level low……Hypothyroidism
TSH Low ………..T3 & T4 level high …….Hyperthyroidism
Parathyroid Glands
Four glands…They are found behind the lobe of thyroid glands.
30 – 60 mg weight – Each
Parathyroid Hormone ….Production
Increase the blood Calcium level = Reduce the calcium level in
bone
Osteoporosis = PTH
Smallest Endocrine glands …. Pineal 0.1gm (100mg)
Smallest Exocrine glands…. Goblet Cells
Exocrine largest glands …Pancrease (60 gm)
Largest Glands …………Liver
Largest Endocrine …Thyroid
Smallest Organs of the body…..Pineal Glands
Adrenal Glands
Supra Renal Glands……..4 cm long…….11.8 gm weight (Each)
Life Saving Glands ……..Emergency Glands …..Angry Glands …..4S
Glands
4S Glands:- Stands For…..
1. Salt Retention …….BP Increase
2. Sugar Metabolism …..Energy Production
3. Sex Hormone Release……Infertility or Fertility
4. Source of Energy
It has 2 parts…..
1. Adrenal Cortex …..90%
Mineralocorticoids
Glucocorticoids
Androgen or Sex Hormone
2. Adrenal Medulla ……10%
Adrenalin…………Prepare for Conflict & Danger ………Fight or
Flight Response
Nor Adrenaline
Cortisol…..Stress Hormone …..Stress response Hormone
Aldosterone
1. Stress management
2. Salt Retention ….BP High
3. Heart Rate increase
4. Antiaallergic Response
5. Anti-inflammatory Response
6. Bronchodilation
7. Heat Production
8. Metabolism Control
9. Sex Hormone Release ======Life Saving Hormone
Q. Stress Hormone is called….
a. Cortisol
b. Aldosterone
c. Adrenalin
d. Nor Adrenaline
Q. The Emergency glands is called…
a. Adrenal
b. Pituitary Glands
c. Parathyroid
d. Testes
Q. The sex hormone is released from…
a. Ovaries
b. Testes
c. Adrenal Glands
d. All of the above
Q. The Fight or Flight Response is seen by the…
a. Thyroid
b. Adrenal
c. Parathyroid
d. Adrenalin
Thymus Glands
Found in Mediastinum. Behind the heart
Old age …Disappears
Child …10 – 20 gm…..
Adult 30 – 60 gm
Old age….Lost
Thymosine Hormone Production …….Lymphocyte & macrophage WBC-
T Lymphocyte …Immune System development
Urinary System
Major Excretory System of the body. Major Excretory Organs – Kidney
Filtration System of the system
Divided into 2 parts:-
1. Upper Urinary Tract……..Kidney & Ureter
2. Lower Urinary Tract ……..Urinary bladder & urethra
Urethra to Kidney …….Urinary System
Kidney – 2……….Pyelonephritis
Ureter – 2 ………मु नल
Urinary Bladder – 1 ……Cystitis
Urethra -1………….. मु माग
Kidney
Renus….Major Excretory Organs
Major organs of urinary system
Filtration Organs of body
Bean Shaped Organs ….Red Colour…150 gm weight
12cm, 6cm & 3cm ….size
Q. Right Kidney is slightly lower than left kidney, this is why
because….
Ans:- Due to the pressure over by Liver
Male Weight ….150 gm
Female weight…135 gm
Kidney 2 parts…
1. Renal Cortex
2. Renal Medulla
The Kidney contains more than 10 lakh nephrons
Nephron filter the blood…..Urine Formation….that urine received
by renal pyramids……..Received by minor calyx……major
calyx……renal pelvis……Ureter…….Urinary Bladder
The most common site for Nephrolithiasis is……….Renal Pelvis
Kidneys Functions
1. Vital Organs. So it dose the vital works
2. Kidney is a major excretory organs
3. Kidney act as a fluid & electrolyte balance
4. PH maintained or Acid Base Balance …Vital Role
5. Renin Production …….Blood Pressure Maintains …major Role
Renin + Angiotensin+ Aldosterone mechanism system = BP
Maintains
Erythropetin secretion………..Helps in RBC production ….Reduce
the chance of anemia
Kidney helps to inactive vit D to active vit D. So the Vitamin D is
called Kidney Vitamin
Excretion of waste material
Excretion of drugs
Q. The BP is control by…..
a. Brains b. Liver c. Kidney d. Heart
BP High ……….RFT Regular Need……..Serum Creatinine Level
Nephron
This is the functional & smallest unit of kidney.
Each Kidney has almost 10-lakh nephron.
Nephron Has 4 parts……
1. Glomerulus Capsule or Bowman’s Capsule
2. Proximal Convoluted Tubule – PCT
3. Loop Of Henley – LH
4. Distal Convoluted Tubule – DCT & Collecting Tube
Q. Acute glomerulonephritis (AGN) is mainly caused by…
a. Gonococcus
b. E coli
c. Pseudomonas
d. Group A Beta Hemolytic Streptococcus