Tipos de sinalização química

Estrutura e fisiologia de receptores

acoplados à proteína G
Mudança conformacional
 Proteína G

Figure 15-31 Molecular Biology of the Cell (© Garland Science 2008)

Figure 15-18b Molecular Biology of the Cell (© Garland Science 2008)
The second messenger concept
Figure 15-34 Molecular Biology of the Cell (© Garland Science 2008)
Adenil ciclase
 Ativação da Proteína cinase A (PKA)

Figure 15-35 Molecular Biology of the Cell (© Garland Science 2008)

Figure 15-18a Molecular Biology of the Cell (© Garland Science 2008)
AMPLIFICAÇÃO DO SINAL
Table 15-1 Molecular Biology of the Cell (© Garland Science 2008)
Toxina colérica: ADP-ribosil-transferase
Cólera
Perda de íons
DIFERENTES TIPOS DE PROTEÍNA G
Proteína Gi
Proteína Gq
Table 15-2 Molecular Biology of the Cell (© Garland Science 2008)
Figure 15-38 Molecular Biology of the Cell (© Garland Science 2008)
Figure 15-39 Molecular Biology of the Cell (© Garland Science 2008)
Figure 15-41a Molecular Biology of the Cell (© Garland Science 2008)
Figure 15-41b Molecular Biology of the Cell (© Garland Science 2008)
 Neurotransmissor

Ativação de
enzimas
 Ativação da PKC

Fig. 1: PKC activation scheme. Protein kinase C is regulated by two membrane-

targeting modules. In solution, the pseudosubstrate (green rectangle) occupies the
active site (open rectangle) of the kinase domain (large blue) of protein kinase C,
thus maintaining it in an inactive form. Binding of two Ca2+ ions to the C2 domain
leads to translocation of the PKC-Ca2+ complex to the PM. Activation of protein
kinase C results when both the C1 and C2 domains bind membranes. PS =
phosphatidylserine and DAG = diacylglycerol.
 Calmodulina

Figure 15-43 Molecular Biology of the Cell (© Garland Science 2008)

 Ativação da CamKII

Figure 15-44 Molecular Biology of the Cell (© Garland Science 2008)

Ativação da fosfatase calcineurina
Ativação da protease calpaína